LOCUS       NM_019545               2042 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus hydroxyacid oxidase 2 (Hao2), mRNA.
ACCESSION   NM_019545
VERSION     NM_019545.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2042)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2042)
  AUTHORS   Jones,J.M., Morrell,J.C. and Gould,S.J.
  TITLE     Identification and characterization of HAOX1, HAOX2, and HAOX3,
            three human peroxisomal 2-hydroxy acid oxidases
  JOURNAL   J Biol Chem 275 (17), 12590-12597 (2000)
   PUBMED   10777549
REFERENCE   5  (bases 1 to 2042)
  AUTHORS   Mulhardt,C., Fischer,M., Gass,P., Simon-Chazottes,D., Guenet,J.L.,
            Kuhse,J., Betz,H. and Becker,C.M.
  TITLE     The spastic mouse: aberrant splicing of glycine receptor beta
            subunit mRNA caused by intronic insertion of L1 element
  JOURNAL   Neuron 13 (4), 1003-1015 (1994)
   PUBMED   7946325
REFERENCE   6  (bases 1 to 2042)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   7  (bases 1 to 2042)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Gene order in linkage group XVI of the house mouse
  JOURNAL   J Hered 70 (4), 239-244 (1979)
   PUBMED   489953
REFERENCE   8  (bases 1 to 2042)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics of hydroxyacid oxidase isozymes in the mouse: localisation
            of Hao-2 on linkage group XVI
  JOURNAL   Heredity (Edinb) 41 (3), 403-406 (1978)
   PUBMED   284003
REFERENCE   9  (bases 1 to 2042)
  AUTHORS   Holmes,R.S. and Masters,C.J.
  TITLE     Genetic control and ontogeny of microbody enzymes: a review
  JOURNAL   Biochem Genet 16 (3-4), 171-190 (1978)
   PUBMED   28117
  REMARK    Review article
REFERENCE   10 (bases 1 to 2042)
  AUTHORS   Holmes,R.S.
  TITLE     The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase
            in the mouse: evidence for multiple gene loci and linkage between
            Hao-2 and Adh-3
  JOURNAL   Genetics 87 (4), 709-716 (1977)
   PUBMED   604164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671965.6, AF272947.1 and BB746253.1.
            
            On Jul 18, 2009 this sequence version replaced NM_019545.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143991.1, BC027754.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL671965.6         37398-37401         c
            5-1856              AF272947.1         1-1852
            1857-2042           BB746253.1         284-469
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.9 cM"
     gene            1..2042
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /note="hydroxyacid oxidase 2"
                     /db_xref="GeneID:56185"
                     /db_xref="MGI:MGI:96012"
     exon            1..78
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /inference="alignment:Splign:2.1.0"
     exon            79..182
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /inference="alignment:Splign:2.1.0"
     exon            183..321
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1252
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /EC_number="1.1.3.15"
                     /note="medium-chain 2-hydroxy acid oxidase HAOX3; HAOX2;
                     medium-chain L-2-hydroxy acid oxidase; (S)-2-hydroxy-acid
                     oxidase, peroxisomal; medium chain alpha-hydroxy acid
                     oxidase; hydroxyacid oxidase 2, kidney; hydroxyacid
                     oxidase (glycolate oxidase) 3"
                     /codon_start=1
                     /product="2-Hydroxyacid oxidase 2"
                     /protein_id="NP_062418.3"
                     /db_xref="CCDS:CCDS17671.1"
                     /db_xref="GeneID:56185"
                     /db_xref="MGI:MGI:96012"
                     /translation="MSLLCLADFKAQAQKQLSKTSWDFIEGEADDGITYNDNLAAFRR
                     IRLRPRYLRDVSKIDTRTTIQGQEINAPICISPTAFHSIAWADGEKSTAKAAQKANIC
                     YVISSYASYTVEDIVAAAPGGLHWFQLYVQPDWDINKQMVQRIEALGFKALVVTVDAP
                     VLGNRRGNKRSLLDLEANIKLKDLRSPGESKSGLPTPLSMPSSSSCWNDLPLLQSMTR
                     LPIILKGILTKEDAELAVKHNIRGIIVSNHGGRQLDEVPASIDALREVVAAVNGKIEV
                     YMDGGVRTGNDVLKALALGARCIFLGRPIIWGLACKGEDGVKEVLDILKEELHTCMAL
                     SGCRSVAEISPDLIQFSRL"
     exon            322..473
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /inference="alignment:Splign:2.1.0"
     exon            474..757
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /inference="alignment:Splign:2.1.0"
     exon            758..967
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1126
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1196
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..2042
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /note="hexamer: AACAAG"
     polyA_site      1860
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /note="major polyA site"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /note="hexamer: AATAAA"
     polyA_site      1984
                     /gene="Hao2"
                     /gene_synonym="Hao-2; Hao3; Haox3"
                     /note="major polyA site"
ORIGIN      
        1 ggtgggcctc tgtagcaggc tttgcatggc tacctctaca tactgctatt gctggctatt
       61 ggaagacctt agtgtcagaa tcttcttgtg tacaagccct gaatggtgtg accaacccaa
      121 gttcctacag catctttgca gctgttgatc tcactctttc gttcctattg gagaaactac
      181 cggcccagca atgtctttgc tgtgtttggc agactttaag gcacaagcac aaaagcagct
      241 gtctaagacc tcctgggatt ttattgaagg agaagctgat gatggcataa cctacaatga
      301 caacttggca gcatttagaa gaatccgcct ccgccccaga tacctgagag atgtgtcaaa
      361 gatagacacc aggaccacaa tccaagggca ggagatcaat gcccccattt gcatctcacc
      421 cacagccttt cattcaattg cctgggcaga tggagaaaag agcacagcta aagctgctca
      481 gaaggccaac atctgctatg tcatcagcag ttatgccagc tatactgtgg aagacattgt
      541 tgctgctgcc cctggaggcc tccattggtt ccaactttat gtgcagccag actgggacat
      601 caacaagcag atggttcaga ggatagaagc cttgggtttc aaagctttgg tggtcactgt
      661 agatgcacct gtacttggca ataggcgagg gaacaagaga agcctgctgg atttggaggc
      721 aaacataaag ctgaaggatc tccgatcccc tggagagagc aagtctggac ttcctactcc
      781 cctgtctatg ccaagttcat cttcctgctg gaatgatctc cccttgcttc agagtatgac
      841 tcggttgccc attatcctca aagggatttt gacaaaagag gatgcagaat tagcagtgaa
      901 gcacaacatc cgaggcatca ttgtttccaa ccatggcggg aggcagcttg atgaggttcc
      961 tgcatctatt gatgctctga gagaagtggt ggctgccgtc aatgggaaaa ttgaagtgta
     1021 catggatggt ggggttcgaa ccggcaatga tgtgttgaag gcactagccc ttggagctag
     1081 gtgcattttt cttgggagac caatcatttg gggccttgcc tgcaagggtg aagatggtgt
     1141 taaggaagtt ttagatattc taaaagaaga actccacact tgtatggccc tttcaggctg
     1201 ccggtcagtt gctgagatca gtccagacct gattcagttc tccagattat aaggacctac
     1261 tgagattgcc tacaagagaa agacaagctt tcaacatagt gtgtgatgct gttcttcttg
     1321 ggtcccattc ataatagaag tttaagccct ctaccctcaa aaattgagac agatggagaa
     1381 aagataggct aaagctacca gagggtgcat ttggatgaag aaataacatc taatgttcta
     1441 caggaaacta gagttaacaa ttaattgact atatcaaaaa gccatgttct agcaagaaag
     1501 gaaatagtta gatctgatgt gacataccag ttaccttcat ttgatcagta gtgcattata
     1561 cataattgaa atgtcatact gtgccataat tatgtgtaat tactatgtat caattaaaat
     1621 atcaatatat gttcaaaaag aaatggggac agggttatcc tgattttatt cattccctcc
     1681 tgcaagaaat atttttaaaa catcaatata tgtagtcaaa ttctgaagca tagtacagca
     1741 tgtgaattat tcaagtttct gtcacagcat gttacagaaa tattatgatc tattgcctaa
     1801 tgtccattgt taacagaagc tgacctcaat aaaaaaacaa gaggaagatt ttgaaactca
     1861 tatttaaaac tttatgacta aattaaaatt aaatattcca gtcatttact gatacatgaa
     1921 aaagaagata tctttattct ggtcataatc attttgtcaa ataaatctaa gccttttcaa
     1981 tgaagtttat agcatgaaaa tatttggaaa gattaaagtc tgagaaaatt tctgctaccc
     2041 ag
//
