LOCUS       NM_010403               2029 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus hydroxyacid oxidase 1, liver (Hao1), mRNA.
ACCESSION   NM_010403
VERSION     NM_010403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2029)
  AUTHORS   Chen,H., Li,X., Sun,Y., Du,Y., Wu,S., Wu,Y., Liu,H., Liu,Y.,
            Wang,Y., Zhao,Q. and Yin,S.
  TITLE     HAO1 negatively regulates liver macrophage activation via the
            NF-kappaB pathway in alcohol-associated liver disease
  JOURNAL   Cell Signal 99, 110436 (2022)
   PUBMED   35953025
  REMARK    GeneRIF: HAO1 negatively regulates liver macrophage activation via
            the NF-kappaB pathway in alcohol-associated liver disease.
REFERENCE   2  (bases 1 to 2029)
  AUTHORS   Li,X., Knight,J., Fargue,S., Buchalski,B., Guan,Z., Inscho,E.W.,
            Liebow,A., Fitzgerald,K., Querbes,W., Todd Lowther,W. and
            Holmes,R.P.
  TITLE     Metabolism of (13)C5-hydroxyproline in mouse models of Primary
            Hyperoxaluria and its inhibition by RNAi therapeutics targeting
            liver glycolate oxidase and hydroxyproline dehydrogenase
  JOURNAL   Biochim Biophys Acta 1862 (2), 233-239 (2016)
   PUBMED   26655602
  REMARK    GeneRIF: Decreasing hepatic glycolate oxidase and HYPDH expression
            decreases oxalate excretion.
REFERENCE   3  (bases 1 to 2029)
  AUTHORS   Labialle,S., Marty,V., Bortolin-Cavaille,M.L., Hoareau-Osman,M.,
            Pradere,J.P., Valet,P., Martin,P.G. and Cavaille,J.
  TITLE     The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain
            controls neonatal metabolic adaptation
  JOURNAL   EMBO J 33 (19), 2216-2230 (2014)
   PUBMED   25124681
REFERENCE   4  (bases 1 to 2029)
  AUTHORS   Shi,C., Wu,F., Zhu,X.C. and Xu,J.
  TITLE     Incorporation of beta-sitosterol into the membrane increases
            resistance to oxidative stress and lipid peroxidation via estrogen
            receptor-mediated PI3K/GSK3beta signaling
  JOURNAL   Biochim Biophys Acta 1830 (3), 2538-2544 (2013)
   PUBMED   23266618
REFERENCE   5  (bases 1 to 2029)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   6  (bases 1 to 2029)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   7  (bases 1 to 2029)
  AUTHORS   Spence,S.E., Gilbert,D.J., Harris,B.S., Davisson,M.T.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Genetic localization of Hao-1, blind-sterile (bs), and Emv-13 on
            mouse chromosome 2
  JOURNAL   Genomics 12 (2), 403-404 (1992)
   PUBMED   1310954
REFERENCE   8  (bases 1 to 2029)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics of hydroxyacid oxidase isozymes in the mouse: localisation
            of Hao-2 on linkage group XVI
  JOURNAL   Heredity (Edinb) 41 (3), 403-406 (1978)
   PUBMED   284003
REFERENCE   9  (bases 1 to 2029)
  AUTHORS   Holmes,R.S.
  TITLE     The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase
            in the mouse: evidence for multiple gene loci and linkage between
            Hao-2 and Adh-3
  JOURNAL   Genetics 87 (4), 709-716 (1977)
   PUBMED   604164
REFERENCE   10 (bases 1 to 2029)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino
            acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid
            oxidase (Hao-1) loci on chromosome 2
  JOURNAL   Biochem Genet 14 (11-12), 981-987 (1976)
   PUBMED   13782
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL845309.2.
            
            On Mar 21, 2007 this sequence version replaced NM_010403.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF104312.1, BC119535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AL845309.2         20890-21046
            158-309             AL845309.2         26962-27113
            310-565             AL845309.2         44445-44700
            566-741             AL845309.2         52082-52257
            742-833             AL845309.2         69580-69671
            834-992             AL845309.2         74086-74244
            993-1062            AL845309.2         74357-74426
            1063-2029           AL845309.2         76915-77881
FEATURES             Location/Qualifiers
     source          1..2029
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 65.65 cM"
     gene            1..2029
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /note="hydroxyacid oxidase 1, liver"
                     /db_xref="GeneID:15112"
                     /db_xref="MGI:MGI:96011"
     exon            1..157
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1133
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /EC_number="1.1.3.15"
                     /EC_number="1.2.3.5"
                     /note="HAOX1; glycolate oxidase 1; glyoxylate oxidase"
                     /codon_start=1
                     /product="2-Hydroxyacid oxidase 1"
                     /protein_id="NP_034533.1"
                     /db_xref="CCDS:CCDS16783.1"
                     /db_xref="GeneID:15112"
                     /db_xref="MGI:MGI:96011"
                     /translation="MLPRLVCISDYEQHVRSVLQKSVYDYYRSGANDQETLADNIQAF
                     SRWKLYPRMLRNVADIDLSTSVLGQRVSMPICVGATAMQCMAHVDGELATVRACQTMG
                     TGMMLSSWATSSIEEVAEAGPEALRWMQLYIYKDREISRQIVKRAEKQGYKAIFVTVD
                     TPYLGNRIDDVRNRFKLPPQLRMKNFETNDLAFSPKGNFGDNSGLAEYVAQAIDPSLS
                     WDDITWLRRLTSLPIVVKGILRGDDAKEAVKHGVDGILVSNHGARQLDGVPATIDVLP
                     EIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLAFQGEKGVQDVLE
                     ILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI"
     exon            158..309
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..565
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..741
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..833
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..992
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1062
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..2029
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1963..1968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /note="hexamer: AATAAA"
     polyA_site      1990
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; Hao-1"
                     /note="major polyA site"
ORIGIN      
        1 ggttgcccta ccctgccaca atgttgcctc gactggtctg catcagtgat tatgaacagc
       61 atgtccgatc agtgcttcag aagtcagtgt atgactatta caggtctggg gcaaatgatc
      121 aggagacgtt agctgataac atccaagcat tttctagatg gaagctctat ccacggatgc
      181 ttcgcaacgt tgctgatatc gatctgtcaa cttctgtttt aggacagaga gtcagcatgc
      241 caatatgtgt tggggctact gccatgcagt gcatggctca cgtggacggg gagctggcca
      301 ctgtgcgagc ctgtcagacc atgggaactg gcatgatgct gagttcttgg gctacctcct
      361 caatagaaga agtggcagaa gctggcccag aggcacttcg ctggatgcaa ctgtacatct
      421 acaaagaccg tgagatcagc agacagatag tgaagcgagc tgagaagcag ggttacaagg
      481 ccatatttgt gactgtggac accccttacc tgggcaaccg cattgatgac gtgcggaaca
      541 ggttcaagct gccaccacaa ctcaggatga aaaactttga aaccaatgat ttggcatttt
      601 ctcctaaggg aaattttgga gacaacagtg gacttgctga atatgtggca caagctatag
      661 acccatctct cagctgggat gatattacat ggctcagacg attgacatca ctgcctattg
      721 ttgtaaaggg cattttgaga ggtgatgatg ccaaggaagc tgttaaacat ggtgtggatg
      781 ggatcttggt gtcgaatcat ggggcgcgac aactggatgg ggtgccagct actattgatg
      841 tcctgccaga gattgttgag gctgtggaag ggaaggtaga agtcttcctg gatgggggag
      901 taaggaaagg tactgatgtt ctcaaagctc tggccctagg agccaaggcc gtttttgtgg
      961 gaagacccat catctggggc ttggctttcc agggggagaa aggtgttcaa gatgtcctcg
     1021 agatattgaa ggaagaattc cgactggcca tggctctgag tgggtgccag aatgtgaaag
     1081 tcatcgacaa gacattggtg aggaaaaatc ctttggctgt ttccaagatc tgacagtgca
     1141 caatattttc ccatctgtat tatttttttt ccagcgtgga ttacttgaca aagagacact
     1201 gtgcagaggg tgaccacaga ctgtaactcc ccacttctat acaaagggtg tcgttctttt
     1261 ccaacaaaat agccacccct tttccttcat tgcttttgac ttttcaatgg gtgtcctagg
     1321 aaccttctag aaagaaatgg acttgcatcc tggaaatata ttaactgtta aaaagaaaac
     1381 attgaaaatg tgtttgggca acgtcatccc ctggcaggct aaagtgctgg ggaacaaaag
     1441 atatcctctg gtgagattgc aggtagcatg ctgaagtgaa agatactgac ctcactgttc
     1501 attaacctgt cttctgttta gatttcctta agacagtggc tcttacagtt tgcacttggc
     1561 tttgaaatgc tggaaatgcc cagagaaaca tgaggtttgg atttgccatg ttgagaaaat
     1621 agcaccaggt agaattgaaa tggatggtgg taatttgtga ttttttttct agaaactttt
     1681 cattttttaa caccctattt ttttgaaggt agatttttag ctatatatca cacgtctgaa
     1741 tatgtctgga tgttttgtgg cactcattgc atttgaaagg gatgtgtcta gtccagttgg
     1801 gaccacatgg agctattttt acttttgaac tttgtctcct cattctcatt ttaaaataag
     1861 tgttgacttc ctaattcctc ttgaatcttt tttgattttc tcacttttcc tcatttatag
     1921 tcacattcag tgtaaagtac atattttgtg gggtccgtga tgaataaaga tttgaaattc
     1981 ttgttcagaa ggaaggcaaa aaaaaaaaaa agtctttcct tttatcaca
//
