LOCUS       NM_010402               2235 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus heart and neural crest derivatives expressed 2
            (Hand2), mRNA.
ACCESSION   NM_010402 XM_973609 XM_974072
VERSION     NM_010402.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Feng,H., Yang,S., Zhang,L., Zhu,J., Li,J. and Yang,Z.
  TITLE     A new Prdm1-Cre line is suitable for studying the second heart
            field development
  JOURNAL   Dev Biol 514, 78-86 (2024)
   PUBMED   38880275
REFERENCE   3  (bases 1 to 2235)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
  REMARK    GeneRIF: TBX3 is essential for establishment of the posterior
            boundary of anterior genes and upregulation of posterior genes
            together with HAND2 during the onset of limb bud development.
REFERENCE   4  (bases 1 to 2235)
  AUTHORS   Plummer,N.W., Smith,K.G. and Jensen,P.
  TITLE     A knock-in allele of Hand2 expressing Dre recombinase
  JOURNAL   Genesis 62 (3), e23601 (2024)
   PUBMED   38703044
REFERENCE   5  (bases 1 to 2235)
  AUTHORS   Lozovska,A., Korovesi,A.G., Dias,A., Lopes,A., Fowler,D.A.,
            Martins,G.G., Novoa,A. and Mallo,M.
  TITLE     Tgfbr1 controls developmental plasticity between the hindlimb and
            external genitalia by remodeling their regulatory landscape
  JOURNAL   Nat Commun 15 (1), 2509 (2024)
   PUBMED   38509075
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2235)
  AUTHORS   Lin,Q., Schwarz,J., Bucana,C. and Olson,E.N.
  TITLE     Control of mouse cardiac morphogenesis and myogenesis by
            transcription factor MEF2C
  JOURNAL   Science 276 (5317), 1404-1407 (1997)
   PUBMED   9162005
REFERENCE   7  (bases 1 to 2235)
  AUTHORS   Molkentin,J.D., Lin,Q., Duncan,S.A. and Olson,E.N.
  TITLE     Requirement of the transcription factor GATA4 for heart tube
            formation and ventral morphogenesis
  JOURNAL   Genes Dev 11 (8), 1061-1072 (1997)
   PUBMED   9136933
REFERENCE   8  (bases 1 to 2235)
  AUTHORS   Srivastava,D., Cserjesi,P. and Olson,E.N.
  TITLE     A subclass of bHLH proteins required for cardiac morphogenesis
  JOURNAL   Science 270 (5244), 1995-1999 (1995)
   PUBMED   8533092
REFERENCE   9  (bases 1 to 2235)
  AUTHORS   Cross,J.C., Flannery,M.L., Blanar,M.A., Steingrimsson,E.,
            Jenkins,N.A., Copeland,N.G., Rutter,W.J. and Werb,Z.
  TITLE     Hxt encodes a basic helix-loop-helix transcription factor that
            regulates trophoblast cell development
  JOURNAL   Development 121 (8), 2513-2523 (1995)
   PUBMED   7671815
REFERENCE   10 (bases 1 to 2235)
  AUTHORS   Hollenberg,S.M., Sternglanz,R., Cheng,P.F. and Weintraub,H.
  TITLE     Identification of a new family of tissue-specific basic
            helix-loop-helix proteins with a two-hybrid system
  JOURNAL   Mol Cell Biol 15 (7), 3813-3822 (1995)
   PUBMED   7791788
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035160.1 and AC119275.12.
            
            On Sep 7, 2007 this sequence version replaced NM_010402.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ131846.1, BQ127448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-930               AK035160.1         3-932
            931-931             AC119275.12        51992-51992         c
            932-1689            AK035160.1         934-1691
            1690-1690           AC119275.12        49933-49933         c
            1691-1767           AK035160.1         1693-1769
            1768-1768           AC119275.12        49855-49855         c
            1769-2235           AK035160.1         1771-2237
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.8 cM"
     gene            1..2235
                     /gene="Hand2"
                     /gene_synonym="bHLHa26; dHAND; Ehand2; Hed; Th2; Thing2"
                     /note="heart and neural crest derivatives expressed 2"
                     /db_xref="GeneID:15111"
                     /db_xref="MGI:MGI:103580"
     exon            1..1479
                     /gene="Hand2"
                     /gene_synonym="bHLHa26; dHAND; Ehand2; Hed; Th2; Thing2"
                     /inference="alignment:Splign:2.1.0"
     CDS             925..1578
                     /gene="Hand2"
                     /gene_synonym="bHLHa26; dHAND; Ehand2; Hed; Th2; Thing2"
                     /note="thing-2; helix-loop-helix transcription factor
                     expressed in embryo and deciduum; deciduum, heart,
                     autonomic nervous system and neural crest
                     derivatives-expressed protein 2; heart and neural crest
                     derivatives expressed transcript 2"
                     /codon_start=1
                     /product="heart- and neural crest derivatives-expressed
                     protein 2"
                     /protein_id="NP_034532.3"
                     /db_xref="CCDS:CCDS22315.1"
                     /db_xref="GeneID:15111"
                     /db_xref="MGI:MGI:103580"
                     /translation="MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFH
                     GWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRG
                     TANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQ
                     NGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVWALELKQ"
     exon            1480..2235
                     /gene="Hand2"
                     /gene_synonym="bHLHa26; dHAND; Ehand2; Hed; Th2; Thing2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1936..1941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hand2"
                     /gene_synonym="bHLHa26; dHAND; Ehand2; Hed; Th2; Thing2"
                     /note="hexamer: AACAAA"
     polyA_site      1951
                     /gene="Hand2"
                     /gene_synonym="bHLHa26; dHAND; Ehand2; Hed; Th2; Thing2"
                     /note="major polyA site"
ORIGIN      
        1 agctgtacat ggagatcttg ctgggaaaat cggcttgctc ccctcaccgc gtccagccca
       61 agagaaccgc cgccgctgcc acccaggagc ttccgcggcc actgtctgag cacacccctc
      121 cgagagtcca ttcgccgctt cccagctccg aggtgccttc aagggcccaa gattcttgtc
      181 cggagaggag aggatcttag aaaatggatg cgctgagacc tctctgcaaa gcctccgaga
      241 gagcctgagg agcgaggacg gacacgttcc ttacagcttt aaaaacaaat cacactcaag
      301 gaccaaaaca acaaccaaat aatttttatt aaaacaataa gcgcccaaga acccagatcg
      361 agctggtggg ggaggggaag gggcaggaag ggggagggtc gcaccgaggt agctccacgc
      421 taagctgcga ccccgccgcc tcccggcaca gccgggccgg ctcctgcagc cccagcttgg
      481 actcgccccg gattccaggt catcttcgga gtcaggagtc ccgtggccgg cgtctgcggg
      541 actgcctcgc gggagccggc cggcactttt gcatgagcac cggagcgctc tgcctggtcg
      601 ctgcagcggg gaacgcggga gccggcgcgc gggctgtaga gctgggcggg cggcggcggc
      661 cagcaagggc gcaccgtgcc gggaccagct cgccgcgccc catggggagc cggcggccgc
      721 ggcacagctg aggcgggccc ggcgggccag gcgcgggccc cgggctgcag cggccccctc
      781 tgcggctgca gggccggccc gggagcccgg gggttggggg gtggggggtg gggaaggccg
      841 ccgatcgccg aggtcggagc ccgatcggag ggcgcggcgg ggctgcgcgc acgctggggc
      901 gcgtggaggg ccacggaagg cgagatgagt ctggtggggg gctttcccca ccaccccgtg
      961 gtgcaccatg agggctaccc attcgccgca gccgccgccg ccgctgccgc cgccgccgcc
     1021 agccgctgca gccacgagga gaacccctac ttccacggct ggcttattgg ccacccggag
     1081 atgtcgcccc ccgactacag tatggccctg tcctacagcc ccgagtacgc cagcggtgcc
     1141 gcgggcctgg accactccca ttatggggga gtgccgcccg gcgccgggcc tcccggcctg
     1201 ggggggccgc gcccggtgaa gcgccggggc accgccaacc gcaaggagcg gcgcaggact
     1261 cagagcatca acagcgcctt cgccgagctg cgcgagtgca tccccaacgt gcccgccgac
     1321 accaaactct ccaagatcaa gacactgcgc ctggccacca gctacatcgc ctacctcatg
     1381 gatctgctgg ccaaggacga ccagaacgga gaggcggagg ccttcaaggc ggagatcaag
     1441 aagaccgacg tgaaagagga gaagaggaag aaagagctga atgagatctt gaaaagcaca
     1501 gtgagcagca acgacaagaa aaccaaaggc cggacaggct ggccacagca cgtctgggcc
     1561 ctggagctca agcagtgaag aagaggagag cagtgagccg ggggccaagg cgccagatgc
     1621 agacccagga ctccccgaaa gccctcgggc tccgttctga ggacttcttg cagttggatc
     1681 atccggttta tttatgtgca atttccttcc ccttctttct gcccgccccc acccacccac
     1741 ctttgagcat ccgctcccca cctccctctc caaaaaaagg tggatatttg aagaaaagca
     1801 ttccatattt taatatgaag aggacactcc cgtgtggtaa gggacccccg tcattctctg
     1861 tgtgtgaatg ttccctcttg gctgtgtaga caccagcgtt gtcccccgcc tccttaccca
     1921 actctttcca gataaaacaa agtggacact agtgcatatg tgaagtgtat ctttttaata
     1981 ctcggccttc ggatataaat attcctgggg gttataaagt tttatttcaa agcagaaaac
     2041 agggccgcta acatttctgt cgggtcggtt atctagtgct gtcacatttc aaatgtcatt
     2101 gtcccctagt cgaagatgtt tccaccagct tcttgttttt gtgcgcttcc gtcctctaaa
     2161 actaagtgga atttaattaa tattgaaggt gtaaacattg taagtattca ataaaccact
     2221 gcgtgttttt tttac
//
