LOCUS       NM_008213               1898 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus heart and neural crest derivatives expressed 1
            (Hand1), mRNA.
ACCESSION   NM_008213
VERSION     NM_008213.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1898)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   2  (bases 1 to 1898)
  AUTHORS   Sivori,M., Dempsey,B., Chettouh,Z., Boismoreau,F., Ayerdi,M.,
            Eymael,A., Baulande,S., Lameiras,S., Coulpier,F., Delattre,O.,
            Rohrer,H., Mirabeau,O. and Brunet,J.F.
  TITLE     The pelvic organs receive no parasympathetic innervation
  JOURNAL   Elife 12, 91576 (2024)
   PUBMED   38488657
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1898)
  AUTHORS   Quilez,S., Dumontier,E., Baim,C., Kam,J. and Cloutier,J.F.
  TITLE     Loss of Neogenin alters branchial arch development and leads to
            craniofacial skeletal defects
  JOURNAL   Front Cell Dev Biol 12, 1256465 (2024)
   PUBMED   38404688
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1898)
  AUTHORS   Grego-Bessa,J., Gomez-Apinaniz,P., Prados,B., Gomez,M.J.,
            MacGrogan,D. and de la Pompa,J.L.
  TITLE     Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in
            Ventricular Development
  JOURNAL   Circ Res 133 (11), 927-943 (2023)
   PUBMED   37846569
REFERENCE   5  (bases 1 to 1898)
  AUTHORS   Wang,R., Yang,X., Chen,J., Zhang,L., Griffiths,J.A., Cui,G.,
            Chen,Y., Qian,Y., Peng,G., Li,J., Wang,L., Marioni,J.C., Tam,P.P.L.
            and Jing,N.
  TITLE     Time space and single-cell resolved tissue lineage trajectories and
            laterality of body plan at gastrulation
  JOURNAL   Nat Commun 14 (1), 5675 (2023)
   PUBMED   37709743
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1898)
  AUTHORS   Srivastava,D., Cserjesi,P. and Olson,E.N.
  TITLE     A subclass of bHLH proteins required for cardiac morphogenesis
  JOURNAL   Science 270 (5244), 1995-1999 (1995)
   PUBMED   8533092
REFERENCE   7  (bases 1 to 1898)
  AUTHORS   Cross,J.C., Flannery,M.L., Blanar,M.A., Steingrimsson,E.,
            Jenkins,N.A., Copeland,N.G., Rutter,W.J. and Werb,Z.
  TITLE     Hxt encodes a basic helix-loop-helix transcription factor that
            regulates trophoblast cell development
  JOURNAL   Development 121 (8), 2513-2523 (1995)
   PUBMED   7671815
REFERENCE   8  (bases 1 to 1898)
  AUTHORS   Cserjesi,P., Brown,D., Lyons,G.E. and Olson,E.N.
  TITLE     Expression of the novel basic helix-loop-helix gene eHAND in neural
            crest derivatives and extraembryonic membranes during mouse
            development
  JOURNAL   Dev Biol 170 (2), 664-678 (1995)
   PUBMED   7649392
REFERENCE   9  (bases 1 to 1898)
  AUTHORS   Hollenberg,S.M., Sternglanz,R., Cheng,P.F. and Weintraub,H.
  TITLE     Identification of a new family of tissue-specific basic
            helix-loop-helix proteins with a two-hybrid system
  JOURNAL   Mol Cell Biol 15 (7), 3813-3822 (1995)
   PUBMED   7791788
REFERENCE   10 (bases 1 to 1898)
  AUTHORS   Oude Elferink,R.P., Ottenhoff,R., van Wijland,M., Smit,J.J.,
            Schinkel,A.H. and Groen,A.K.
  TITLE     Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the
            mouse
  JOURNAL   J Clin Invest 95 (1), 31-38 (1995)
   PUBMED   7814632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732587.8.
            
            On Nov 17, 2006 this sequence version replaced NM_008213.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U21226.1, BC050182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-904               AL732587.8         64167-65070         c
            905-1898            AL732587.8         61636-62629         c
FEATURES             Location/Qualifiers
     source          1..1898
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 35.27 cM"
     gene            1..1898
                     /gene="Hand1"
                     /gene_synonym="bHLHa27; eHAND; Ehand1; Hxt; Th1; Thing1"
                     /note="heart and neural crest derivatives expressed 1"
                     /db_xref="GeneID:15110"
                     /db_xref="MGI:MGI:103577"
     exon            1..904
                     /gene="Hand1"
                     /gene_synonym="bHLHa27; eHAND; Ehand1; Hxt; Th1; Thing1"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..1012
                     /gene="Hand1"
                     /gene_synonym="bHLHa27; eHAND; Ehand1; Hxt; Th1; Thing1"
                     /note="thing-1; heart and neural crest derivatives
                     expressed transcript 1; helix-loop-helix transcription
                     factor expressed in extraembryonic mesoderm and
                     trophoblast; extraembryonic tissues, heart, autonomic
                     nervous system and neural crest derivatives-expressed
                     protein 1"
                     /codon_start=1
                     /product="heart- and neural crest derivatives-expressed
                     protein 1"
                     /protein_id="NP_032239.1"
                     /db_xref="CCDS:CCDS24721.1"
                     /db_xref="GeneID:15110"
                     /db_xref="MGI:MGI:103577"
                     /translation="MNLVGSYAHHHHHHHSHPPHPMLHEPFLFGPASRCHQERPYFQS
                     WLLSPADAAPDFPAGGPPPTTAVAAAAYGPDARPSQSPGRLEALGSRLPKRKGSGPKK
                     ERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQAGDPE
                     AFKAELKKTDGGRESKRKRELPQQPESFPPASGPGEKRIKGRTGWPQQVWALELNQ"
     exon            905..1898
                     /gene="Hand1"
                     /gene_synonym="bHLHa27; eHAND; Ehand1; Hxt; Th1; Thing1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttagaattgt gtggcgcttg ctgagcataa aacttgggac cgccaccccc ttccctcctc
       61 ctgccattgg ctccggctag aggttgacat caaagccgag gccttatata agcaggatcc
      121 tggtggcaag tccgcagaag ggttaaaccc ggtctttgga cgtctgaacc cttctccctc
      181 gttgcctaca gaaaccttca agaggtcggc aggtccttcg tgtcatctcc agccttgctc
      241 gctcaggact ctccaaaccc cagccagttc gctgcctctg gagcccacgg tgaccccctt
      301 ctgtggggcg catggggcgg tgctaattgg gctgacagca caggccagga gcctctccaa
      361 catgaacctc gtgggcagct acgcacatca tcaccatcat caccactcac acccgccgca
      421 ccccatgctc cacgaaccct tcctgtttgg cccggcctcg cgttgccacc aggagcggcc
      481 ttacttccag agctggctgc tgagcccggc tgatgctgcc ccagatttcc ctgccggcgg
      541 gccaccacct accaccgcag tagcagcggc tgcctatggt cccgatgcca ggccgagtca
      601 gagcccaggt cggctggagg ctcttggaag ccgcctgccc aaacgaaaag gctcaggacc
      661 caagaaggag aggagacgca cagagagcat taacagcgcg ttcgcggagc tgcgtgagtg
      721 catccccaat gtgcccgccg acaccaagct ctccaagatc aagactctgc gcctggctac
      781 cagttacatc gcctacttga tggacgtgct ggccaaggat gcacaagcag gtgaccccga
      841 ggccttcaag gctgaactca aaaagacgga tggtggtcgc gaaagcaagc ggaaaaggga
      901 gttgcctcag cagcccgaaa gcttccctcc tgcctcgggg cccggcgaga agaggattaa
      961 agggcgcacc ggctggcctc agcaagtctg ggcgctggag ctaaaccagt gagaccaggc
     1021 caacgccgcc ggagaacccg gccgaggctg gcccacctgg ctacgtggag aggagaggaa
     1081 aggacgcagc ggctacggcg ggtctcccgg tgcccgcgcg cgtttcgccc agtctctgcg
     1141 gagcaccgga gggtcggcgg ttgcaactac ccactaggat cgcacgtgca atgtcatttg
     1201 aatttgttaa tacataagag aaagagaaat ttttatatat gttcacttcc cgccgagggc
     1261 ggctcttgaa ggctcgactc aagatgggac tggagaagac caagcccccg aagacacacc
     1321 cttccaaccc atctgggtgg aactcaaccc caaaagccat ggtcgcgccg ctctctggct
     1381 cgctctctcg tccccttctt ggctctgcgt cagtaccctg atgccttctc gagttaaaat
     1441 gcaataagag taattggtag tttctaacca ggaagactga cgctgcctgg gttgacctct
     1501 cctgagcagc gatggttttc cttcttgtcg ctacacttcc tacctagagg gaaggcgttg
     1561 ctcccttgcg cagcacctct gctttccaag ggaaatcttt cccttccttt cccttccctt
     1621 ccctcccctc tcctcctcct ttcccctctt ccgtcctctt acctcctctt tctcttcctt
     1681 ccttctcctt catttctttc cttttccttc taaataaaag cgttcccatt cgttgctgaa
     1741 tttgtaacgt atttaaacta cctatcatgc ctgttgctct caggtataca tctccctacc
     1801 cccaccctct ttctacctca aatcagtgtg accactcgca gccccaccct ttgccaaagc
     1861 agtatctatg ctcttgactt aataaaaagt tttcagag
//
