LOCUS       NM_183257                437 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus hepcidin antimicrobial peptide 2 (Hamp2), mRNA.
ACCESSION   NM_183257
VERSION     NM_183257.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 437)
  AUTHORS   Rong,R., Wei,Y., Li,L., Wang,T., Zhu,H., Xiao,G. and Wang,Y.
  TITLE     Image-based quantification of histological features as a function
            of spatial location using the Tissue Positioning System
  JOURNAL   EBioMedicine 94, 104698 (2023)
   PUBMED   37453365
REFERENCE   2  (bases 1 to 437)
  AUTHORS   Wei,Y., Wang,Y.G., Jia,Y., Li,L., Yoon,J., Zhang,S., Wang,Z.,
            Zhang,Y., Zhu,M., Sharma,T., Lin,Y.H., Hsieh,M.H., Albrecht,J.H.,
            Le,P.T., Rosen,C.J., Wang,T. and Zhu,H.
  TITLE     Liver homeostasis is maintained by midlobular zone 2 hepatocytes
  JOURNAL   Science 371 (6532) (2021)
   PUBMED   33632817
  REMARK    Erratum:[Science. 2021 Sep 3;373(6559):eabl8195. doi:
            10.1126/science.abl8195. PMID: 34516857]
REFERENCE   3  (bases 1 to 437)
  AUTHORS   Lefebvre,T., Millot,S., Richard,E., Blouin,J.M., Lalanne,M.,
            Lamrissi-Garcia,I., Costet,P., Lyoumi,S., Gouya,L., Puy,H.,
            Moreau-Gaudry,F., de Verneuil,H., Karim,Z. and Ged,C.
  TITLE     Genetic background influences hepcidin response to iron imbalance
            in a mouse model of hemolytic anemia (Congenital erythropoietic
            porphyria)
  JOURNAL   Biochem Biophys Res Commun 520 (2), 297-303 (2019)
   PUBMED   31601421
  REMARK    GeneRIF: Hepcidin role in the iron homeostasis.
REFERENCE   4  (bases 1 to 437)
  AUTHORS   Suzuki,T., Kikuguchi,C., Nishijima,S., Nagashima,T., Takahashi,A.,
            Okada,M. and Yamamoto,T.
  TITLE     Postnatal liver functional maturation requires Cnot
            complex-mediated decay of mRNAs encoding cell cycle and immature
            liver genes
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30733279
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 437)
  AUTHORS   Iizuka,D., Yoshioka,S., Kawai,H., Okazaki,E., Kiriyama,K.,
            Izumi,S., Nishimura,M., Shimada,Y., Kamiya,K. and Suzuki,F.
  TITLE     Hepcidin-2 in mouse urine as a candidate radiation-responsive
            molecule
  JOURNAL   J Radiat Res 57 (2), 142-149 (2016)
   PUBMED   26826199
  REMARK    GeneRIF: radiation exposure directly or indirectly induces urinary
            excretion of hepcidin-2 at least in part by the upregulation of
            Hamp2 mRNA in the liver.
REFERENCE   6  (bases 1 to 437)
  AUTHORS   Mazur,A., Feillet-Coudray,C., Romier,B., Bayle,D., Gueux,E.,
            Ruivard,M., Coudray,C. and Rayssiguier,Y.
  TITLE     Dietary iron regulates hepatic hepcidin 1 and 2 mRNAs in mice
  JOURNAL   Metabolism 52 (10), 1229-1231 (2003)
   PUBMED   14564671
  REMARK    GeneRIF: Both Hepc 1 and Hepc 2 expression responds coordinately to
            dietary iron. This work provides additional evidence of the key
            role of Hepc in the regulation of iron homeostasis.
REFERENCE   7  (bases 1 to 437)
  AUTHORS   Ilyin,G., Courselaud,B., Troadec,M.B., Pigeon,C., Alizadeh,M.,
            Leroyer,P., Brissot,P. and Loreal,O.
  TITLE     Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for
            different patterns of expression and co-inducibility during iron
            overload
  JOURNAL   FEBS Lett 542 (1-3), 22-26 (2003)
   PUBMED   12729891
  REMARK    GeneRIF: Comparative analysis of sequence, genomic structure and
            expression of the hepcidin 1 and 2 genes.
REFERENCE   8  (bases 1 to 437)
  AUTHORS   Nicolas,G., Bennoun,M., Porteu,A., Mativet,S., Beaumont,C.,
            Grandchamp,B., Sirito,M., Sawadogo,M., Kahn,A. and Vaulont,S.
  TITLE     Severe iron deficiency anemia in transgenic mice expressing liver
            hepcidin
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4596-4601 (2002)
   PUBMED   11930010
REFERENCE   9  (bases 1 to 437)
  AUTHORS   Nicolas,G., Bennoun,M., Devaux,I., Beaumont,C., Grandchamp,B.,
            Kahn,A. and Vaulont,S.
  TITLE     Lack of hepcidin gene expression and severe tissue iron overload in
            upstream stimulatory factor 2 (USF2) knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8780-8785 (2001)
   PUBMED   11447267
REFERENCE   10 (bases 1 to 437)
  AUTHORS   Kawamoto,S., Matsumoto,Y., Mizuno,K., Okubo,K. and Matsubara,K.
  TITLE     Expression profiles of active genes in human and mouse livers
  JOURNAL   Gene 174 (1), 151-158 (1996)
   PUBMED   8863742
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK008993.1 and D17962.1.
            
            [WARNING] On Feb 5, 2025 this sequence was replaced by NM_183257.5.
            
            On Aug 12, 2016 this sequence version replaced NM_183257.3.
            
            Summary: This gene encodes a peptide hormone that functions in the
            regulation of systemic iron metabolism. The encoded preproprotein
            is synthesized in the hepatocytes where it undergoes proteolytic
            processing to generate disulfide-linked mature peptides that are
            secreted into the bloodstream. Transgenic mice overexpressing the
            encoded protein develop normally with hematologic parameters
            similar to the non-transgenic mice. This gene is located adjacent
            to a related hepcidin gene on chromosome 7. [provided by RefSeq,
            Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086895.1, AK008993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               AK008993.1         2-413
            413-437             D17962.1           218-242
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.27 cM"
     gene            1..437
                     /gene="Hamp2"
                     /gene_synonym="1810073K19Rik; HEPC2"
                     /note="hepcidin antimicrobial peptide 2"
                     /db_xref="GeneID:66438"
                     /db_xref="MGI:MGI:2153530"
     exon            1..136
                     /gene="Hamp2"
                     /gene_synonym="1810073K19Rik; HEPC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..301
                     /gene="Hamp2"
                     /gene_synonym="1810073K19Rik; HEPC2"
                     /note="hepcidin-2"
                     /codon_start=1
                     /product="hepcidin-2 preproprotein"
                     /protein_id="NP_899080.2"
                     /db_xref="CCDS:CCDS39894.2"
                     /db_xref="GeneID:66438"
                     /db_xref="MGI:MGI:2153530"
                     /translation="MALSTRTQAACLLLLLLASLSSTTYLQQQMRQTTELQPLHGEES
                     RADIAIPMQKRRKRDINFPICRFCCQCCNKPSCGICCEE"
     exon            137..196
                     /gene="Hamp2"
                     /gene_synonym="1810073K19Rik; HEPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            197..437
                     /gene="Hamp2"
                     /gene_synonym="1810073K19Rik; HEPC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      391..396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hamp2"
                     /gene_synonym="1810073K19Rik; HEPC2"
                     /note="hexamer: AATAAA"
     polyA_site      420
                     /gene="Hamp2"
                     /gene_synonym="1810073K19Rik; HEPC2"
                     /note="major polyA site"
ORIGIN      
        1 gacagccacc acacaagtcc ttagactgca cagcagaaca ggaggcatga tggcactcag
       61 cactcggacc caggctgcct gtctcctgct tctcctcctt gccagcctga gcagcaccac
      121 ctatctccag caacagatga gacagactac agagctgcag cctttgcacg gggaagaaag
      181 cagggcagac attgcgatcc caatgcagaa gagaaggaag agagacatca acttccccat
      241 ctgcagattc tgctgtcagt gctgtaacaa accctcctgt ggtatctgtt gtgaagaata
      301 gagagcctag agccacatcc tgacctctct acacccctgc agcccctcaa ccccagtatt
      361 cattcctgcc ctctccagca atgaccttga aataaagagg atgactttat tttcaaacta
      421 tgatgtctgc attttca
//
