LOCUS       NM_032541                422 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus hepcidin antimicrobial peptide (Hamp), mRNA.
ACCESSION   NM_032541
VERSION     NM_032541.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 422)
  AUTHORS   Dou,J., Chen,X., Zhang,J., Yang,L., Lin,J., Zhu,W., Huang,D. and
            Tan,X.
  TITLE     P. Gingivalis induce macrophage polarization by regulating hepcidin
            expression in chronic apical periodontitis
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113139 (2024)
   PUBMED   39278061
  REMARK    GeneRIF: P. Gingivalis induce macrophage polarization by regulating
            hepcidin expression in chronic apical periodontitis.
REFERENCE   2  (bases 1 to 422)
  AUTHORS   Bai,X., Wang,B., Cui,Y., Tian,S., Zhang,Y., You,L., Chang,Y.Z. and
            Gao,G.
  TITLE     Hepcidin deficiency impairs hippocampal neurogenesis and mediates
            brain atrophy and memory decline in mice
  JOURNAL   J Neuroinflammation 21 (1), 15 (2024)
   PUBMED   38195497
  REMARK    GeneRIF: Hepcidin deficiency impairs hippocampal neurogenesis and
            mediates brain atrophy and memory decline in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 422)
  AUTHORS   Helman,S.L., Wilkins,S.J., Chan,J.C.J., Hartel,G., Wallace,D.F.,
            Anderson,G.J. and Frazer,D.M.
  TITLE     A Decrease in Maternal Iron Levels Is the Predominant Factor
            Suppressing Hepcidin during Pregnancy in Mice
  JOURNAL   Int J Mol Sci 24 (18), 14379 (2023)
   PUBMED   37762679
  REMARK    GeneRIF: A Decrease in Maternal Iron Levels Is the Predominant
            Factor Suppressing Hepcidin during Pregnancy in Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 422)
  AUTHORS   Ohta,K., Ito,M., Chida,T., Nakashima,K., Sakai,S., Kanegae,Y.,
            Kawasaki,H., Aoshima,T., Takabayashi,S., Takahashi,H., Kawata,K.,
            Shoji,I., Sawasaki,T., Suda,T. and Suzuki,T.
  TITLE     Role of hepcidin upregulation and proteolytic cleavage of
            ferroportin 1 in hepatitis C virus-induced iron accumulation
  JOURNAL   PLoS Pathog 19 (8), e1011591 (2023)
   PUBMED   37585449
  REMARK    GeneRIF: Role of hepcidin upregulation and proteolytic cleavage of
            ferroportin 1 in hepatitis C virus-induced iron accumulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 422)
  AUTHORS   Deschemin,J.C., Ransy,C., Bouillaud,F., Chung,S., Galy,B.,
            Peyssonnaux,C. and Vaulont,S.
  TITLE     Hepcidin deficiency in mice impairs white adipose tissue browning
            possibly due to a defect in de novo adipogenesis
  JOURNAL   Sci Rep 13 (1), 12794 (2023)
   PUBMED   37550331
  REMARK    GeneRIF: Hepcidin deficiency in mice impairs white adipose tissue
            browning possibly due to a defect in de novo adipogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 422)
  AUTHORS   Nicolas,G., Bennoun,M., Porteu,A., Mativet,S., Beaumont,C.,
            Grandchamp,B., Sirito,M., Sawadogo,M., Kahn,A. and Vaulont,S.
  TITLE     Severe iron deficiency anemia in transgenic mice expressing liver
            hepcidin
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4596-4601 (2002)
   PUBMED   11930010
REFERENCE   7  (bases 1 to 422)
  AUTHORS   Nicolas,G., Bennoun,M., Devaux,I., Beaumont,C., Grandchamp,B.,
            Kahn,A. and Vaulont,S.
  TITLE     Lack of hepcidin gene expression and severe tissue iron overload in
            upstream stimulatory factor 2 (USF2) knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8780-8785 (2001)
   PUBMED   11447267
REFERENCE   8  (bases 1 to 422)
  AUTHORS   Pigeon,C., Ilyin,G., Courselaud,B., Leroyer,P., Turlin,B.,
            Brissot,P. and Loreal,O.
  TITLE     A new mouse liver-specific gene, encoding a protein homologous to
            human antimicrobial peptide hepcidin, is overexpressed during iron
            overload
  JOURNAL   J Biol Chem 276 (11), 7811-7819 (2001)
   PUBMED   11113132
REFERENCE   9  (bases 1 to 422)
  AUTHORS   Park,C.H., Valore,E.V., Waring,A.J. and Ganz,T.
  TITLE     Hepcidin, a urinary antimicrobial peptide synthesized in the liver
  JOURNAL   J Biol Chem 276 (11), 7806-7810 (2001)
   PUBMED   11113131
REFERENCE   10 (bases 1 to 422)
  AUTHORS   Venta,P.J., Montgomery,J.C., Hewett-Emmett,D., Wiebauer,K. and
            Tashian,R.E.
  TITLE     Structure and exon to protein domain relationships of the mouse
            carbonic anhydrase II gene
  JOURNAL   J Biol Chem 260 (22), 12130-12135 (1985)
   PUBMED   2995362
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY448092.1 and AF297664.1.
            
            On Aug 9, 2016 this sequence version replaced NM_032541.1.
            
            Summary: This gene encodes hepcidin, an antimicrobial peptide and
            master hormonal regulator of systemic iron metabolism. The encoded
            preproprotein is synthesized in the hepatocytes where it undergoes
            proteolytic processing to generate disulfide-linked mature peptides
            that are secreted into the bloodstream. Mice lacking the encoded
            protein develop multivisceral iron overlaod, with sparing of the
            spleen macrophages. Certain mutations in the human ortholog of this
            gene cause hemochromatosis type 2B, also known as juvenile
            hemochromatosis. This gene is located adjacent to a related
            hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016].
            
            Sequence Note: An in-frame AUG is located 1 codon upstream of the
            annotated translation start site but is not being annotated as a
            start site since it is not conserved and is in a weak Kozak
            sequence context.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB950373.1, CB951177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BY448092.1         2-13
            13-422              AF297664.1         1-410
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.27 cM"
     gene            1..422
                     /gene="Hamp"
                     /gene_synonym="Hamp1; Hepc; Hepc1"
                     /note="hepcidin antimicrobial peptide"
                     /db_xref="GeneID:84506"
                     /db_xref="MGI:MGI:1933533"
     exon            1..133
                     /gene="Hamp"
                     /gene_synonym="Hamp1; Hepc; Hepc1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..193
                     /gene="Hamp"
                     /gene_synonym="Hamp1; Hepc; Hepc1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..407
                     /gene="Hamp"
                     /gene_synonym="Hamp1; Hepc; Hepc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      384..389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hamp"
                     /gene_synonym="Hamp1; Hepc; Hepc1"
                     /note="hexamer: AATAAA"
     polyA_site      407
                     /gene="Hamp"
                     /gene_synonym="Hamp1; Hepc; Hepc1"
                     /note="major polyA site"
ORIGIN      
        1 agccaccaca caagtcctta gactgcacag cagaacagaa ggcatgatgg cactcagcac
       61 tcggacccag gctgcctgtc tcctgcttct cctccttgcc agcctgagca gcaccaccta
      121 tctccatcaa cagatgagac agactacaga gctgcagcct ttgcacgggg aagaaagcag
      181 ggcagacatt gcgataccaa tgcagaagag aaggaagaga gacaccaact tccccatctg
      241 catcttctgc tgtaaatgct gtaacaattc ccagtgtggt atctgttgca aaacatagcc
      301 tagagccaca tcctgacctc tctacacccc tgcagcccct caaccccatt atttattcct
      361 gccctcccca ccaatgacct tgaaataaag acgattttat tttcaaaaaa aaaaaaaaaa
      421 aa
//
