LOCUS       NM_010401               2776 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus histidine ammonia lyase (Hal), mRNA.
ACCESSION   NM_010401
VERSION     NM_010401.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2776)
  AUTHORS   Planas-Paz,L., Orsini,V., Boulter,L., Calabrese,D., Pikiolek,M.,
            Nigsch,F., Xie,Y., Roma,G., Donovan,A., Marti,P., Beckmann,N.,
            Dill,M.T., Carbone,W., Bergling,S., Isken,A., Mueller,M.,
            Kinzel,B., Yang,Y., Mao,X., Nicholson,T.B., Zamponi,R.,
            Capodieci,P., Valdez,R., Rivera,D., Loew,A., Ukomadu,C.,
            Terracciano,L.M., Bouwmeester,T., Cong,F., Heim,M.H., Forbes,S.J.,
            Ruffner,H. and Tchorz,J.S.
  TITLE     The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size
  JOURNAL   Nat Cell Biol 18 (5), 467-479 (2016)
   PUBMED   27088858
  REMARK    Erratum:[Nat Cell Biol. 2016 Oct 27;18(11):1260. doi:
            10.1038/ncb3428.. PMID: 27784900]
REFERENCE   2  (bases 1 to 2776)
  AUTHORS   Barresi,C., Stremnitzer,C., Mlitz,V., Kezic,S., Kammeyer,A.,
            Ghannadan,M., Posa-Markaryan,K., Selden,C., Tschachler,E. and
            Eckhart,L.
  TITLE     Increased sensitivity of histidinemic mice to UVB radiation
            suggests a crucial role of endogenous urocanic acid in
            photoprotection
  JOURNAL   J Invest Dermatol 131 (1), 188-194 (2011)
   PUBMED   20686493
  REMARK    GeneRIF: photoprotective role of endogenous urocanic acid in the
            murine skin using histidinemic mice, in which the gene encoding
            histidase is mutated
REFERENCE   3  (bases 1 to 2776)
  AUTHORS   Mellor,N., Themis,M., Selden,C., Jones,M. and Hodgson,H.J.
  TITLE     Characteristics of murine histidinaemia and its potential for
            genetic manipulation
  JOURNAL   Liver Int 24 (4), 354-360 (2004)
   PUBMED   15287859
REFERENCE   4  (bases 1 to 2776)
  AUTHORS   Dunlevy,J.R., Chakravarti,S., Gyalzen,P., Vergnes,J.P. and
            Hassell,J.R.
  TITLE     Cloning and chromosomal localization of mouse keratocan, a corneal
            keratan sulfate proteoglycan
  JOURNAL   Mamm Genome 9 (4), 316-319 (1998)
   PUBMED   9530631
REFERENCE   5  (bases 1 to 2776)
  AUTHORS   Cabib,S., Oliverio,A., Ventura,R., Lucchese,F. and
            Puglisi-Allegra,S.
  TITLE     Brain dopamine receptor plasticity: testing a diathesis-stress
            hypothesis in an animal model
  JOURNAL   Psychopharmacology (Berl) 132 (2), 153-160 (1997)
   PUBMED   9266612
REFERENCE   6  (bases 1 to 2776)
  AUTHORS   Taylor,R.G., Grieco,D., Clarke,G.A., McInnes,R.R. and Taylor,B.A.
  TITLE     Identification of the mutation in murine histidinemia (his) and
            genetic mapping of the murine histidase locus (Hal) on chromosome
            10
  JOURNAL   Genomics 16 (1), 231-240 (1993)
   PUBMED   8486363
REFERENCE   7  (bases 1 to 2776)
  AUTHORS   Arfin,S.M., Hanford,W.C. and Taylor,B.A.
  TITLE     Assignment of histidase-regulating locus to chromosome 10 of the
            mouse
  JOURNAL   Biochem Genet 17 (5-6), 529-535 (1979)
   PUBMED   518536
REFERENCE   8  (bases 1 to 2776)
  AUTHORS   Hanford,W.C. and Arfin,S.M.
  TITLE     Genetic differences inthe te of histidase synthesis in inbred mice
  JOURNAL   J Biol Chem 252 (19), 6695-6699 (1977)
   PUBMED   893436
REFERENCE   9  (bases 1 to 2776)
  AUTHORS   Kacser,H., Mya,K.M., Duncker,M., Wright,A.F., Bulfield,G.,
            McLaren,A. and Lyon,M.F.
  TITLE     Maternal histidine metabolism and its effect on foetal development
            in the mouse
  JOURNAL   Nature 265 (5591), 262-266 (1977)
   PUBMED   834272
REFERENCE   10 (bases 1 to 2776)
  AUTHORS   Bulfield,G. and Kacser,H.
  TITLE     Histamine and histidine levels in the brain of the histidinaemic
            mutant mouse
  JOURNAL   J Neurochem 24 (2), 403-405 (1975)
   PUBMED   1113117
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK014518.1 and AK028963.1.
            
            On Dec 4, 2015 this sequence version replaced NM_010401.3.
            
            Summary: This gene encodes a member of the histidase protein
            family. The encoded protein is a cytosolic enzyme which catalyzes
            the first reaction in histidine catabolism. Defects in this protein
            cause histidinemia, which is characterized by increased histidine
            in blood, urine, and cerebrospinal fluid. [provided by RefSeq, Dec
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014518.1, BC157999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2758              AK014518.1         1-2758
            2759-2776           AK028963.1         2466-2483
FEATURES             Location/Qualifiers
     source          1..2776
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 48.49 cM"
     gene            1..2776
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /note="histidine ammonia lyase"
                     /db_xref="GeneID:15109"
                     /db_xref="MGI:MGI:96010"
     exon            1..610
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..2337
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /EC_number="4.3.1.3"
                     /codon_start=1
                     /product="histidine ammonia-lyase"
                     /protein_id="NP_034531.1"
                     /db_xref="CCDS:CCDS36036.1"
                     /db_xref="GeneID:15109"
                     /db_xref="MGI:MGI:96010"
                     /translation="MPRYTVHVRGEWLAVPCQDGKLTVGWLGREAVRRYMKNKPDNGG
                     FTSVDEVQFLVHRCKGLGLLDNEDELEVALEDNEFVEVVIEGDVMSPDFIPSQPEGVF
                     LYSKYREPEKYIALDGDSLSTEDLVNLGKGRYKIKLTSIAEKKVQQSREVIDSIIKER
                     TVVYGITTGFGKFARTVIPANKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVL
                     AKGYSGISLETLKQVIEAFNASCLSYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSP
                     KSGWADAKYVLEAHGLKPIVLKPKEGLALINGTQMITSLGCEALERASAIARQADIVA
                     ALTLEVLKGTTKAFDTDIHAVRPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQ
                     DAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNPMVFASRGETISGGNFHGEYPA
                     KALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAALVS
                     ESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVVEHVEQVLAIELLAACQGIEF
                     LRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIEKYR
                     MEHIPESRPLSPTAFSLESLRKNSATIPESDDL"
     exon            611..671
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            672..699
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            700..774
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            775..847
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            848..914
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            915..952
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1078
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1218
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1266
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1414
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1510
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1569
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1650
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1716
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1882
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2017
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2126
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2196
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2776
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2508
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
                     /note="major polyA site"
     polyA_site      2703
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
     polyA_site      2719
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
     polyA_site      2761
                     /gene="Hal"
                     /gene_synonym="his; histidase; Hsd"
ORIGIN      
        1 gaaagggaga gagagaacgg ggaaccctgg tcagaaggac ttccagggtc agagaactac
       61 aaggttacat taaaagtggg ctcagctacc catatccctg tctcctgcac ctagttcagc
      121 atccagaaag gccaaaggaa caccagagac cgcaatcaat atttgtttaa agtgtgaatg
      181 gctaaaggca agggaagggg tgtgttctga aagtccactc tcagtctcac tgccaaccac
      241 accccagcag acactcccct ccctggtaaa ggataaaggc tctccccagt cgaggactgt
      301 aggaaaggag ccagcccttg gttacagtgg cctgctgctc agaagggcta tagcatctga
      361 gccatgccta ggtacacagt gcacgtgcgt ggggaatggc tggcggtgcc ctgtcaggat
      421 gggaagctca ctgttggctg gctgggccgt gaggctgtgc gacgctacat gaagaacaaa
      481 ccggacaatg gtggcttcac ttcggtggat gaagtgcaat tccttgtgca tcggtgcaag
      541 ggcctgggcc tgctggacaa tgaggacgag ctggaggtgg ccttagagga caatgagttc
      601 gtagaagtgg tgattgaagg tgatgtgatg tctcctgatt tcattccgtc gcagccagaa
      661 ggagttttcc tatacagcaa ataccgggag cctgaaaaat acattgccct agatggggac
      721 agtctgagca cagaggatct ggtcaacctg ggcaagggac gttacaagat aaagctcact
      781 tcaattgctg agaagaaagt gcagcagtcc cgggaggtca tcgacagcat catcaaagaa
      841 agaacagttg tttatggcat caccacaggt tttggaaaat ttgctagaac tgtaatccct
      901 gccaataagc tacaggagct tcaagtcaac ttagtccgtt cccattcttc aggtgttggg
      961 aaaccactca gtcctgagag gtgtcggatg ctcttggctt tgaggatcaa cgtcttagcc
     1021 aaaggttaca gtgggatttc cttggagacg ctgaaacaag ttattgaagc atttaatgcc
     1081 tcctgcctgt cctatgttcc agagaaagga actgtgggtg ccagcggaga ccttgcccca
     1141 ctctctcatc ttgctctggg gctcatcgga gaaggaaaga tgtggtcccc gaagagtggc
     1201 tgggcagatg ctaaatatgt tctagaagcc catggactga aaccaattgt cttgaaacca
     1261 aaagaaggcc tggcactcat caatgggaca cagatgatca cttccctggg ctgtgaagcc
     1321 ctggagcgag ccagcgccat tgcccggcaa gctgatattg tggctgcctt gaccctggag
     1381 gtgctgaagg gcaccaccaa agccttcgat accgacatcc atgctgtccg acctcaccgt
     1441 gggcaaattg aagttgcttt ccgattccgg tccctcctgg actcggatca ccacccatca
     1501 gaaatcgcag aaagccacag gttctgcgat cgtgttcagg acgcgtacac cttacgctgc
     1561 tgtccacagg tccacggtgt ggtgaacgac acaatagcct ttgtgaagga catcatcact
     1621 acagaactga acagcgccac agacaatcct atggtctttg ccagtcgagg ggagacaatt
     1681 tcaggaggaa acttccatgg tgaataccca gccaaagccc tggactattt ggccattggt
     1741 gtccatgaac ttgcggcaat tagtgaaaga agaatcgaaa ggctgtgtaa tccttccctc
     1801 agcgagctgc ctgccttcct ggtggctgaa ggaggtctca attctgggtt catgatagcc
     1861 cactgcaccg cagcagccct ggtgtctgag agcaaggctc tgtgccaccc ttcatctgtg
     1921 gactcactct cgaccagtgc tgctacagaa gaccacgtct ccatgggagg atgggcagcc
     1981 aggaaagccc tcagggtcgt cgagcacgtg gaacaagtgc tagccattga gcttctcgcg
     2041 gcctgccagg gtatagagtt tctgcgcccc ctgaaaacaa ccactccgct ggagaaggtg
     2101 tacgacctgg tgcgctccgt agtaaggccc tggataaaag atcgcttcat ggccccggac
     2161 attgaggcag cacacaggtt gcttcttgac caaaaggttt gggaggttgc cgcaccgtac
     2221 atcgagaaat acagaatgga gcacattccg gaatccagac cgctttctcc aacagcgttt
     2281 tcactagaat ctctccgaaa gaactcagcc acaatcccag agtctgacga tctttaacgg
     2341 gcttcctcga ggacaggcac atcagatggg cctgagctta gcacagcact ggtgtgttga
     2401 tggagagaga gtctcaggaa ctgcctgtaa tgtgtaaaac tcatctcttt tcaaacatac
     2461 tctggatagg ccatggcagc aatgcagtgg ctgaacccag agccctgatc ttgttttctt
     2521 gttactatgg tttgaggagt actgggtgcc ttgtggttgt ggagttgtct ttcttgataa
     2581 tataaacagg ctacttaaaa aaaaaaacag ccacaattcc ataggtttat ttttactctt
     2641 ggaattagga aaatcaattc agagcactct tttaaaaaca ttagattttg tgaactttta
     2701 aaacaattgt cttgggaaac tctctacttg actaattgta ctaataccat aatctgacaa
     2761 atacgtttca agtcag
//
