LOCUS       NM_001409596            1125 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus hydroxyacyl glutathione hydrolase (Hagh), transcript
            variant 9, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001409596
VERSION     NM_001409596.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1125)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1125)
  AUTHORS   Dafre,A.L., Schmitz,A.E. and Maher,P.
  TITLE     Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK-
            and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase
            2 in HT22 Nerve Cells
  JOURNAL   Oxid Med Cell Longev 2019, 2715810 (2019)
   PUBMED   31049129
  REMARK    GeneRIF: Hyperosmotic stress induced AMPK activation, but this was
            not responsible for its effects on mTOR activity or autophagy
            induction. Moreover, the decrease in Trx1 and Glo2 induced by
            hyperosmotic stress was independent of both autophagy and AMPK
            activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1125)
  AUTHORS   Shin,M.J., Kim,D.W., Lee,Y.P., Ahn,E.H., Jo,H.S., Kim,D.S.,
            Kwon,O.S., Kang,T.C., Cho,Y.J., Park,J., Eum,W.S. and Choi,S.Y.
  TITLE     Tat-glyoxalase protein inhibits against ischemic neuronal cell
            damage and ameliorates ischemic injury
  JOURNAL   Free Radic Biol Med 67, 195-210 (2014)
   PUBMED   24252591
  REMARK    GeneRIF: Glyoxalase expression prevents against ischemic neuronal
            cell damage and ameliorates ischemic injury.
REFERENCE   4  (bases 1 to 1125)
  AUTHORS   Belanger,M., Yang,J., Petit,J.M., Laroche,T., Magistretti,P.J. and
            Allaman,I.
  TITLE     Role of the glyoxalase system in astrocyte-mediated neuroprotection
  JOURNAL   J Neurosci 31 (50), 18338-18352 (2011)
   PUBMED   22171037
REFERENCE   5  (bases 1 to 1125)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1125)
  AUTHORS   Kargul,G.J., Nagaraja,R., Shimada,T., Grahovac,M.J., Lim,M.K.,
            Nakashima,H., Waeltz,P., Ma,P., Chen,E., Schlessinger,D. and
            Ko,M.S.
  TITLE     Eleven densely clustered genes, six of them novel, in 176 kb of
            mouse t-complex DNA
  JOURNAL   Genome Res 10 (7), 916-923 (2000)
   PUBMED   10899141
REFERENCE   7  (bases 1 to 1125)
  AUTHORS   Toth,L.A. and Williams,R.W.
  TITLE     A quantitative genetic analysis of slow-wave sleep and rapid-eye
            movement sleep in CXB recombinant inbred mice
  JOURNAL   Behav Genet 29 (5), 329-337 (1999)
   PUBMED   10765561
REFERENCE   8  (bases 1 to 1125)
  AUTHORS   Tan,H. and Whitney,J.B. 3rd.
  TITLE     Genomic rearrangement of the alpha-globin gene complex during
            mammalian evolution
  JOURNAL   Biochem Genet 31 (11-12), 473-484 (1993)
   PUBMED   8166621
REFERENCE   9  (bases 1 to 1125)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   10 (bases 1 to 1125)
  AUTHORS   Bonhomme,F., Catalan,J., Britton-Davidian,J., Chapman,V.M.,
            Moriwaki,K., Nevo,E. and Thaler,L.
  TITLE     Biochemical diversity and evolution in the genus Mus
  JOURNAL   Biochem Genet 22 (3-4), 275-303 (1984)
   PUBMED   6375655
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166102.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.321161.1,
                                           SRR17784647.494445.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC166102.2         92130-92238         c
            110-285             AC166102.2         89432-89607         c
            286-350             AC166102.2         88642-88706         c
            351-468             AC166102.2         85583-85700         c
            469-577             AC166102.2         84714-84822         c
            578-681             AC166102.2         81289-81392         c
            682-787             AC166102.2         80920-81025         c
            788-867             AC166102.2         78582-78661         c
            868-1125            AC166102.2         77888-78145         c
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..1125
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /note="hydroxyacyl glutathione hydrolase"
                     /db_xref="GeneID:14651"
                     /db_xref="MGI:MGI:95745"
     exon            1..109
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            110..285
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1017
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /EC_number="3.1.2.6"
                     /note="isoform 9 is encoded by transcript variant 9;
                     hydroxyacylglutathione hydrolase, mitochondrial;
                     glyoxalase II; round spermatid protein RSP29; glx II;
                     glyoxylase 2"
                     /codon_start=1
                     /product="hydroxyacylglutathione hydrolase, mitochondrial
                     isoform 9"
                     /protein_id="NP_001396525.1"
                     /db_xref="GeneID:14651"
                     /db_xref="MGI:MGI:95745"
                     /translation="MKVELLPALTDNYMYLIIDEDTQEAAIVDPVQPQKVIEAAKKHR
                     VKLTTVLTTHHHWDHAGGNEKLVKLEPGLKVYGGDDRIGALTHKVTHLSTLQVGSLSV
                     KCLSTPCHTSGHICYFVSKPGSSEPSAVFTGDTLFVAGCGKFYEGTADEMYKALLEVL
                     GRLPPDTKVYCGHEYTVNNLKFARHVEPGNAAIQEKLAWAKVREVCHRGAHGAIHPGR
                     RVHLQPLHESEGEDCATACWRDRPCDHHEGHPQGEGPVQGASGLRHTHAGTGTSNRLA
                     CC"
     exon            286..350
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            351..468
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            469..577
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            578..681
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            682..787
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            788..867
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1125
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1125
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /note="major polyA site"
ORIGIN      
        1 atgtgaccac cgactccccc ggactacggc ggcctccaga ggactggctt cggacgctgt
       61 ccaggtcgga gcggccccgc ccttccttgc gcagcagcgg gacgctgagg tcaggccctg
      121 ctgggactat ctctgtgtca ctcagacttc aggaagaatc tgactgtgca gcaagacata
      181 atgaaggttg aactactgcc tgccctgact gacaactaca tgtacctgat cattgatgag
      241 gacacccagg aggccgccat cgtggaccca gtgcaaccac agaaggttat agaagctgcg
      301 aaaaagcacc gtgtgaaact gaccacagtg ctcaccactc accaccactg ggaccacgct
      361 ggtgggaacg agaagctggt gaagctggag cctgggctga aggtttatgg aggtgatgac
      421 cgcatcggag ccttgactca caaggtcaca cacctctcca cactgcaggt ggggtctctc
      481 agtgtcaaat gcctgtcaac accctgccat acttcgggac acatctgtta ctttgtgagc
      541 aagcctggga gctcagagcc ttctgctgtg ttcacaggtg acacattgtt tgttgctggc
      601 tgtgggaagt tctatgaggg aactgcagat gagatgtaca aggcgctgct tgaagtcttg
      661 ggccggcttc ctccagacac aaaagtctac tgtggtcatg aatacaccgt aaacaacctt
      721 aagtttgcac gccatgtgga gcccggcaat gctgccattc aagagaaact agcctgggcc
      781 aaggtgagag aagtatgcca tcggggagcc cacggtgcca tccaccctgg cagaagagtt
      841 cacctacaac cccttcatga gagtgaagga gaagactgtg caacagcatg ctggcgagac
      901 agaccctgtg accaccatga gggccatccg cagggagaag gaccagttca aggtgcctcg
      961 ggactgaggc acacccacgc tgggacaggg acttctaacc gactggcctg ctgctaatgc
     1021 aggacagtct acttttcagt taattcagag cccttagctt gtgttatcaa atgttctaat
     1081 gcatatttat aagagaaaaa aggtttaaag tatttattcc cataa
//
