LOCUS       NM_001409586            1131 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus hydroxyacyl glutathione hydrolase (Hagh), transcript
            variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001409586
VERSION     NM_001409586.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1131)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1131)
  AUTHORS   Dafre,A.L., Schmitz,A.E. and Maher,P.
  TITLE     Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK-
            and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase
            2 in HT22 Nerve Cells
  JOURNAL   Oxid Med Cell Longev 2019, 2715810 (2019)
   PUBMED   31049129
  REMARK    GeneRIF: Hyperosmotic stress induced AMPK activation, but this was
            not responsible for its effects on mTOR activity or autophagy
            induction. Moreover, the decrease in Trx1 and Glo2 induced by
            hyperosmotic stress was independent of both autophagy and AMPK
            activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1131)
  AUTHORS   Shin,M.J., Kim,D.W., Lee,Y.P., Ahn,E.H., Jo,H.S., Kim,D.S.,
            Kwon,O.S., Kang,T.C., Cho,Y.J., Park,J., Eum,W.S. and Choi,S.Y.
  TITLE     Tat-glyoxalase protein inhibits against ischemic neuronal cell
            damage and ameliorates ischemic injury
  JOURNAL   Free Radic Biol Med 67, 195-210 (2014)
   PUBMED   24252591
  REMARK    GeneRIF: Glyoxalase expression prevents against ischemic neuronal
            cell damage and ameliorates ischemic injury.
REFERENCE   4  (bases 1 to 1131)
  AUTHORS   Belanger,M., Yang,J., Petit,J.M., Laroche,T., Magistretti,P.J. and
            Allaman,I.
  TITLE     Role of the glyoxalase system in astrocyte-mediated neuroprotection
  JOURNAL   J Neurosci 31 (50), 18338-18352 (2011)
   PUBMED   22171037
REFERENCE   5  (bases 1 to 1131)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1131)
  AUTHORS   Kargul,G.J., Nagaraja,R., Shimada,T., Grahovac,M.J., Lim,M.K.,
            Nakashima,H., Waeltz,P., Ma,P., Chen,E., Schlessinger,D. and
            Ko,M.S.
  TITLE     Eleven densely clustered genes, six of them novel, in 176 kb of
            mouse t-complex DNA
  JOURNAL   Genome Res 10 (7), 916-923 (2000)
   PUBMED   10899141
REFERENCE   7  (bases 1 to 1131)
  AUTHORS   Toth,L.A. and Williams,R.W.
  TITLE     A quantitative genetic analysis of slow-wave sleep and rapid-eye
            movement sleep in CXB recombinant inbred mice
  JOURNAL   Behav Genet 29 (5), 329-337 (1999)
   PUBMED   10765561
REFERENCE   8  (bases 1 to 1131)
  AUTHORS   Tan,H. and Whitney,J.B. 3rd.
  TITLE     Genomic rearrangement of the alpha-globin gene complex during
            mammalian evolution
  JOURNAL   Biochem Genet 31 (11-12), 473-484 (1993)
   PUBMED   8166621
REFERENCE   9  (bases 1 to 1131)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   10 (bases 1 to 1131)
  AUTHORS   Bonhomme,F., Catalan,J., Britton-Davidian,J., Chapman,V.M.,
            Moriwaki,K., Nevo,E. and Thaler,L.
  TITLE     Biochemical diversity and evolution in the genus Mus
  JOURNAL   Biochem Genet 22 (3-4), 275-303 (1984)
   PUBMED   6375655
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166102.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.767525.1,
                                           SRR17253012.1571395.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC166102.2         91670-91784         c
            116-291             AC166102.2         89432-89607         c
            292-356             AC166102.2         88642-88706         c
            357-474             AC166102.2         85583-85700         c
            475-583             AC166102.2         84714-84822         c
            584-687             AC166102.2         81289-81392         c
            688-793             AC166102.2         80920-81025         c
            794-873             AC166102.2         78582-78661         c
            874-1131            AC166102.2         77888-78145         c
FEATURES             Location/Qualifiers
     source          1..1131
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..1131
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /note="hydroxyacyl glutathione hydrolase"
                     /db_xref="GeneID:14651"
                     /db_xref="MGI:MGI:95745"
     exon            1..115
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1023
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /EC_number="3.1.2.6"
                     /note="isoform 3 is encoded by transcript variant 3;
                     hydroxyacylglutathione hydrolase, mitochondrial;
                     glyoxalase II; round spermatid protein RSP29; glx II;
                     glyoxylase 2"
                     /codon_start=1
                     /product="hydroxyacylglutathione hydrolase, mitochondrial
                     isoform 3"
                     /protein_id="NP_001396515.1"
                     /db_xref="GeneID:14651"
                     /db_xref="MGI:MGI:95745"
                     /translation="MVLGRGSLCLRSLSALGATCARRGLGQALLGLSLCHSDFRKNLT
                     VQQDIMKVELLPALTDNYMYLIIDEDTQEAAIVDPVQPQKVIEAAKKHRVKLTTVLTT
                     HHHWDHAGGNEKLVKLEPGLKVYGGDDRIGALTHKVTHLSTLQVGSLSVKCLSTPCHT
                     SGHICYFVSKPGSSEPSAVFTGDTLFVAGCGKFYEGTADEMYKALLEVLGRLPPDTKV
                     YCGHEYTVNNLKFARHVEPGNAAIQEKLAWAKVREVCHRGAHGAIHPGRRVHLQPLHE
                     SEGEDCATACWRDRPCDHHEGHPQGEGPVQGASGLRHTHAGTGTSNRLACC"
     exon            116..291
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            292..356
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            357..474
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            475..583
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            584..687
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            688..793
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            794..873
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1131
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1131
                     /gene="Hagh"
                     /gene_synonym="Glo-2; Glo2; Rsp29"
                     /note="major polyA site"
ORIGIN      
        1 gttgcggact ccgcgacccg gctgtgcacc ccgtgggtca tggtgctggg tcgcgggtcg
       61 ctgtgtctcc ggagcctgtc agcgctggga gccacctgcg cgcgccgtgg tctgggtcag
      121 gccctgctgg gactatctct gtgtcactca gacttcagga agaatctgac tgtgcagcaa
      181 gacataatga aggttgaact actgcctgcc ctgactgaca actacatgta cctgatcatt
      241 gatgaggaca cccaggaggc cgccatcgtg gacccagtgc aaccacagaa ggttatagaa
      301 gctgcgaaaa agcaccgtgt gaaactgacc acagtgctca ccactcacca ccactgggac
      361 cacgctggtg ggaacgagaa gctggtgaag ctggagcctg ggctgaaggt ttatggaggt
      421 gatgaccgca tcggagcctt gactcacaag gtcacacacc tctccacact gcaggtgggg
      481 tctctcagtg tcaaatgcct gtcaacaccc tgccatactt cgggacacat ctgttacttt
      541 gtgagcaagc ctgggagctc agagccttct gctgtgttca caggtgacac attgtttgtt
      601 gctggctgtg ggaagttcta tgagggaact gcagatgaga tgtacaaggc gctgcttgaa
      661 gtcttgggcc ggcttcctcc agacacaaaa gtctactgtg gtcatgaata caccgtaaac
      721 aaccttaagt ttgcacgcca tgtggagccc ggcaatgctg ccattcaaga gaaactagcc
      781 tgggccaagg tgagagaagt atgccatcgg ggagcccacg gtgccatcca ccctggcaga
      841 agagttcacc tacaacccct tcatgagagt gaaggagaag actgtgcaac agcatgctgg
      901 cgagacagac cctgtgacca ccatgagggc catccgcagg gagaaggacc agttcaaggt
      961 gcctcgggac tgaggcacac ccacgctggg acagggactt ctaaccgact ggcctgctgc
     1021 taatgcagga cagtctactt ttcagttaat tcagagccct tagcttgtgt tatcaaatgt
     1081 tctaatgcat atttataaga gaaaaaaggt ttaaagtatt tattcccata a
//
