LOCUS       NM_145558               2045 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus hydroxyacyl-CoA dehydrogenase trifunctional
            multienzyme complex subunit beta (Hadhb), transcript variant 3,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_145558
VERSION     NM_145558.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Vieira Neto,E., Wang,M., Szuminsky,A.J., Ferraro,L., Koppes,E.,
            Wang,Y., Van't Land,C., Mohsen,A.W., Zanatta,G., El-Gharbawy,A.H.,
            Anthonymuthu,T.S., Tyurina,Y.Y., Tyurin,V.A., Kagan,V., Bayir,H.
            and Vockley,J.
  TITLE     Mitochondrial bioenergetics and cardiolipin remodeling
            abnormalities in mitochondrial trifunctional protein deficiency
  JOURNAL   JCI Insight 9 (17), e176887 (2024)
   PUBMED   39088276
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2045)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2045)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   4  (bases 1 to 2045)
  AUTHORS   Nakayama,Y., Fujiu,K., Yuki,R., Oishi,Y., Morioka,M.S., Isagawa,T.,
            Matsuda,J., Oshima,T., Matsubara,T., Sugita,J., Kudo,F., Kaneda,A.,
            Endo,Y., Nakayama,T., Nagai,R., Komuro,I. and Manabe,I.
  TITLE     A long noncoding RNA regulates inflammation resolution by mouse
            macrophages through fatty acid oxidation activation
  JOURNAL   Proc Natl Acad Sci U S A 117 (25), 14365-14375 (2020)
   PUBMED   32513690
  REMARK    GeneRIF: A long noncoding RNA regulates inflammation resolution by
            mouse macrophages through fatty acid oxidation activation.
REFERENCE   5  (bases 1 to 2045)
  AUTHORS   Makarewich,C.A., Baskin,K.K., Munir,A.Z., Bezprozvannaya,S.,
            Sharma,G., Khemtong,C., Shah,A.M., McAnally,J.R., Malloy,C.R.,
            Szweda,L.I., Bassel-Duby,R. and Olson,E.N.
  TITLE     MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid
            beta-Oxidation
  JOURNAL   Cell Rep 23 (13), 3701-3709 (2018)
   PUBMED   29949755
REFERENCE   6  (bases 1 to 2045)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 2045)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 2045)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 2045)
  AUTHORS   Ibdah,J.A., Paul,H., Zhao,Y., Binford,S., Salleng,K., Cline,M.,
            Matern,D., Bennett,M.J., Rinaldo,P. and Strauss,A.W.
  TITLE     Lack of mitochondrial trifunctional protein in mice causes neonatal
            hypoglycemia and sudden death
  JOURNAL   J Clin Invest 107 (11), 1403-1409 (2001)
   PUBMED   11390422
REFERENCE   10 (bases 1 to 2045)
  AUTHORS   Del Punta,K., Rothman,A., Rodriguez,I. and Mombaerts,P.
  TITLE     Sequence diversity and genomic organization of vomeronasal receptor
            genes in the mouse
  JOURNAL   Genome Res 10 (12), 1958-1967 (2000)
   PUBMED   11116090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY337615.1, AK150889.1 and BE945269.1.
            
            On Jan 31, 2014 this sequence version replaced NM_145558.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150889.1, AK083767.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY337615.1         2-41
            41-2022             AK150889.1         3-1984
            2023-2045           BE945269.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.04 cM"
     gene            1..2045
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /note="hydroxyacyl-CoA dehydrogenase trifunctional
                     multienzyme complex subunit beta"
                     /db_xref="GeneID:231086"
                     /db_xref="MGI:MGI:2136381"
     exon            1..87
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            88..162
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1523
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /EC_number="2.3.1.16"
                     /EC_number="2.3.1.155"
                     /note="trifunctional enzyme subunit beta, mitochondrial;
                     hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A
                     thiolase/enoyl-Coenzyme A hydratase (trifunctional
                     protein), beta aubunit; hydroxyacyl-Coenzyme A
                     dehydrogenase/3-ketoacyl-Coenzyme A
                     thiolase/enoyl-Coenzyme A hydratase (trifunctional
                     protein), beta subunit"
                     /codon_start=1
                     /product="trifunctional enzyme subunit beta, mitochondrial
                     precursor"
                     /protein_id="NP_663533.1"
                     /db_xref="CCDS:CCDS39045.1"
                     /db_xref="GeneID:231086"
                     /db_xref="MGI:MGI:2136381"
                     /translation="MTTILTSTFRNLSTTSKWALRSSIRPLSCSSQLHSAPAVQTKSK
                     KTLAKPNMKNIVVVEGVRIPFLLSGTSYKDLMPHDLARAALSGLLHRTNIPKDVVDYI
                     IFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISSNQAMTTAVGLIASGQCDV
                     VVAGGVELMSDVPIRHSRNMRKMMLDLNKAKTLGQRLSLLSKFRLNFLSPELPAVAEF
                     STNETMGHSADRLAAAFAVSRMEQDEYALRSHSLAKKAQDEGHLSDIVPFKVPGKDTV
                     TKDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMSEDRALAMGYKP
                     KAYLRDFIYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFK
                     AMDSDWFAQNYMGRKTKVGSPPLEKFNIWGGSLSLGHPFGATGCRLVMAAANRLRKDG
                     GQYALVAACAAGGQGHAMIVEAYPK"
     exon            163..207
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            208..307
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            308..352
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            353..452
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            453..540
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            541..728
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            729..909
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1031
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1111
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1159
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1247
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1322
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1487
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..2028
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1999..2004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /note="hexamer: AATAAA"
     polyA_site      2020
                     /gene="Hadhb"
                     /gene_synonym="4930479F15Rik; Mtpb; TP-beta"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgggag ccgcccctcg gcgtgggcgg acgtttgtca gtctggactt gaccttgttg
       61 gcagcggcag ttttcgcgga ctctaagatt tcagaatgac taccatcttg acttccactt
      121 ttagaaactt gtcaactaca tcaaaatggg ctctcagatc ttctataaga cctctgagct
      181 gttcttccca actgcactct gccccagctg tccagaccaa gtcaaagaag actttagcaa
      241 aacccaatat gaagaatatt gtggtggtgg aaggggtccg cattccattt ctgctgtcag
      301 gcacttcgta taaagaccta atgccacatg acttggctag agctgcactt tcgggtttgt
      361 tgcatcggac caatattcca aaggatgttg ttgattatat catctttggt acagttattc
      421 aggaagtgaa aacaagcaat gtggctagag aggctgccct gggagctggc ttctctgata
      481 agactccagc tcacactgtc accatggctt gtatctcttc aaaccaagcc atgaccacag
      541 ctgttggtct gatagcttct ggccagtgtg atgtcgtcgt ggctggtggt gttgagttaa
      601 tgtctgatgt ccctattcgt cattcaagaa atatgaggaa aatgatgctt gatctcaata
      661 aagccaagac tctgggccag cgcctgtcct tactcagtaa attcagattg aattttctgt
      721 cccctgagct ccctgcagtg gctgagttct ccactaatga gaccatgggc cactctgcag
      781 accgactggc tgctgccttt gctgtttctc gaatggaaca ggatgaatat gcactgcgtt
      841 ctcatagtct ggccaagaag gcacaggatg aaggacacct ttctgatatt gtacccttca
      901 aagtaccagg aaaggacaca gttaccaaag ataatgggat ccgtccttcc tcactggagc
      961 aaatggccaa actaaaacct gcgttcatca aaccctatgg cacagtgaca gctgcaaatt
     1021 cttctttcct gactgatggc gcttctgcga tgctaatcat gtcagaggac agagctctgg
     1081 ccatgggtta taaaccaaag gcatatttga gggattttat atatgtgtcc caggatccga
     1141 aagatcagct tttactcgga ccaacatatg ctactccaaa agttttagaa aaggcagggt
     1201 taaccatgaa tgatatcgat gcttttgaat ttcatgaagc cttctcaggc cagattttag
     1261 ctaactttaa agccatggat tctgattggt ttgcacaaaa ctacatgggt aggaaaacca
     1321 aggttggatc acctcctctg gagaagttta atatctgggg cggatcactg tctctggggc
     1381 acccttttgg agccactggc tgtcggctgg tcatggcagc tgccaacaga ctgaggaagg
     1441 atggaggcca gtatgcttta gtggctgcct gtgcagctgg aggacagggt catgctatga
     1501 ttgtggaagc ttaccccaaa tgactgctct agaaggaggc gaccgactga tctcttcagc
     1561 acttgcactg ggcaatgcca tttcaatgca ctaccaagtg atacctgcag ttcctagctc
     1621 ttcttaggaa acaacatttg tggccttctc ttaaatactt tgcaatccag ccttgccagt
     1681 gttcgaggtt ttcgataatc acagcttctg ctctctaagt tccagactat tacagatgtt
     1741 tgcgcagttc ctgttatttc ttttcacaga gactaatggc tgctagccac ttggagagag
     1801 agaggctagc tcaggtttag aatcgtcttt gtaacatttg cagatactcc ttattcctgt
     1861 ctgtgtcata gagataatta tttttttcta aaatacaaac cggtgtgcct aagttaactt
     1921 actatagaaa aaaaaataat ctaaacatct cttaaacctg aaatgcttag agacatagat
     1981 accatgttgg ttgaccttaa taaagtagac atgtattaga ggactgttaa aaaaaaaaaa
     2041 aaaaa
//
