LOCUS       NM_008212               1801 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus hydroxyacyl-Coenzyme A dehydrogenase (Hadh), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_008212
VERSION     NM_008212.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1801)
  AUTHORS   St-Louis,J.L., El Jellas,K., Velasco,K., Slipp,B.A., Hu,J.,
            Helgeland,G., Steine,S.J., De Jesus,D.F., Kulkarni,R.N. and
            Molven,A.
  TITLE     Deficiency of the metabolic enzyme SCHAD in pancreatic beta-cells
            promotes amino acid-sensitive hypoglycemia
  JOURNAL   J Biol Chem 299 (8), 104986 (2023)
   PUBMED   37392854
REFERENCE   2  (bases 1 to 1801)
  AUTHORS   Zhu,H., Wang,H., Cheng,Y., Liu,D., Zhang,A., Wen,Z. and Gao,J.
  TITLE     Hadh deficiency induced oligoasthenoteratozoospermia through the
            TNF-alpha/Bcl-2 pathway in male mice
  JOURNAL   FASEB J 36 (12), e22661 (2022)
   PUBMED   36398584
  REMARK    GeneRIF: Hadh deficiency induced oligoasthenoteratozoospermia
            through the TNF-alpha/Bcl-2 pathway in male mice.
REFERENCE   3  (bases 1 to 1801)
  AUTHORS   Son,J.S., Chae,S.A., Zhao,L., Wang,H., de Avila,J.M., Zhu,M.J.,
            Jiang,Z. and Du,M.
  TITLE     Maternal exercise intergenerationally drives muscle-based
            thermogenesis via activation of apelin-AMPK signaling
  JOURNAL   EBioMedicine 76, 103842 (2022)
   PUBMED   35081489
REFERENCE   4  (bases 1 to 1801)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1801)
  AUTHORS   Li,J., Deng,S.P., Wei,G. and Yu,P.
  TITLE     CITGeneDB: a comprehensive database of human and mouse genes
            enhancing or suppressing cold-induced thermogenesis validated by
            perturbation experiments in mice
  JOURNAL   Database (Oxford) 2018 (2018)
   PUBMED   29688375
REFERENCE   6  (bases 1 to 1801)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1801)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1801)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 1801)
  AUTHORS   Nomura,M., Takihara,Y. and Shimada,K.
  TITLE     Isolation of a cDNA clone encoding mouse 3-hydroxyacyl CoA
            dehydrogenase
  JOURNAL   Gene 160 (2), 309-310 (1995)
   PUBMED   7642117
REFERENCE   10 (bases 1 to 1801)
  AUTHORS   Nomura,M., Takihara,Y. and Shimada,K.
  TITLE     Isolation and characterization of retinoic acid-inducible cDNA
            clones in F9 cells: one of the early inducible clones encodes a
            novel protein sharing several highly homologous regions with a
            Drosophila polyhomeotic protein
  JOURNAL   Differentiation 57 (1), 39-50 (1994)
   PUBMED   8070621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123634.10, AK132260.1, AK148486.1 and AI845880.1.
            
            On Aug 14, 2013 this sequence version replaced NM_008212.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064712.1, AK148486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC123634.10        27755-27792
            39-1292             AK132260.1         2-1255
            1293-1784           AK148486.1         1230-1721
            1785-1801           AI845880.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 60.86 cM"
     gene            1..1801
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /note="hydroxyacyl-Coenzyme A dehydrogenase"
                     /db_xref="GeneID:15107"
                     /db_xref="MGI:MGI:96009"
     exon            1..226
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1039
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /EC_number="1.1.1.35"
                     /note="L-3-hydroxyacyl-Coenzyme A dehydrogenase, short
                     chain; hydroxyacyl-coenzyme A dehydrogenase,
                     mitochondrial; medium and short chain
                     L-3-hydroxyacyl-coenzyme A dehydrogenase; short-chain
                     3-hydroxyacyl-CoA dehydrogenase; hydroxylacyl-Coenzyme A
                     dehydrogenase-dehydrogenase"
                     /codon_start=1
                     /product="hydroxyacyl-coenzyme A dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_032238.2"
                     /db_xref="CCDS:CCDS38640.1"
                     /db_xref="GeneID:15107"
                     /db_xref="MGI:MGI:96009"
                     /translation="MAFVTRQFLRSMSSSSSASAAAKKILIKHVTVIGGGLMGAGIAQ
                     VAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAGDEFVEKTLSCLST
                     STDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANAT
                     TRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFI
                     VNRLLVPYLIEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDG
                     WHEMEPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK"
     exon            227..355
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /inference="alignment:Splign:2.1.0"
     exon            356..513
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /inference="alignment:Splign:2.1.0"
     exon            514..640
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /inference="alignment:Splign:2.1.0"
     exon            641..730
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /inference="alignment:Splign:2.1.0"
     exon            731..803
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /inference="alignment:Splign:2.1.0"
     exon            804..920
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1789
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1742..1747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /note="hexamer: AATAAA"
     regulatory      1765..1770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /note="hexamer: CATAAA"
     polyA_site      1766
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
                     /note="major polyA site"
     polyA_site      1789
                     /gene="Hadh"
                     /gene_synonym="Hadhsc; HCDH; Schad"
ORIGIN      
        1 gaggccccgc ccccaacgtc gccgaccccg cccacgacgc tccgggacct ctcgcgctgt
       61 ccccactgct cctcctcggc tgctgcactg agctatggcg ttcgtgacca ggcaattctt
      121 gcgctccatg tcctcctctt cctctgcgtc ggcggccgcc aagaagatcc tgatcaagca
      181 tgtgaccgtc atcggcggcg ggctgatggg cgccggcatc gcgcaggtag ctgcagcaac
      241 tggccataca gtagtattgg tggaccaaac ggaagacatc ctggcaaaat ccaagaaggg
      301 aattgaggag agtctaaaga ggatggcaaa gaagaagttc acagaaaacc ctaaggctgg
      361 agatgagttt gtggagaaga ccctgagctg cctttcaacc agcaccgatg cggcatccgt
      421 ggtgcacagc acagacctgg tggtggaggc cattgtggag aacctgaagc tgaagaacga
      481 gctgttccag aggctggaca agttcgctgc agaacacacc atctttgcca gcaacacgtc
      541 ttctttgcag atcacaaaca tagccaatgc caccaccaga caagaccgat ttgctggcct
      601 ccactttttc aaccccgtgc ctatgatgaa gcttgtggag gtcatcaaaa caccgatgac
      661 cagccagaag acatttgaat ctctggtgga cttttgtaaa accttaggaa agcatcctgt
      721 ctcttgcaag gacactcctg gattcatcgt gaaccgactc ttggtgccat acctcattga
      781 ggccgtcagg ctacacgagc gaggcgatgc gtctaaggaa gacatcgata cagcgatgaa
      841 gctgggagct gggtatccca tgggtccgtt tgagcttctt gactatgttg gactggatac
      901 tacaaagttc atcttggacg ggtggcatga aatggagcca gagaacccct tatttcagcc
      961 cagtccttcc atgaataatc tggtggccca gaagaagctg ggcaagaaga ccggagaagg
     1021 attttacaaa tacaagtgac acttccccca gcaacacctc cagccagcca tgggacaagg
     1081 atgagcaagc cctgggcagg tggtaccgag gcttgccagg ggcggctcag tgggccctcc
     1141 cttgcagtct ctctgaagta atcttttgac tagttgcagt catggggttc ttccactgaa
     1201 atggaattct ctagtttagt ctgttctctg actttttctg aaaaaaaatt acacccttgg
     1261 tgccttggag caacatcttt tttttttttt ttcctgaacc ttgccacttt ttgtaaaaag
     1321 cgttgcttag actcattccc tcaggtcttc tgaaaatgag tattctatgt ttatcggtgt
     1381 tgaaccccag gggcaggagc cacggggcct acagatgcac ccaagggcag cagccagtag
     1441 gacgtgaggt cttgcctgcc tgggaacatt tgcagcctgc agcctcgagc cttagcctac
     1501 attctgggcc tgacaggaaa tgttctgtct ttctttaccc cacaccagga ctcctggagt
     1561 ggtgggcaaa tacctgtgag cttgtttttt gggggaaagg cctatctttg aggccattca
     1621 gatcttaacc atcactgtcc gtccttcttg tttcttccgg tgaaatctgt gctaccaagt
     1681 gcctatgaat tgactctact aaaatgaaat cttttaattt gtaaacattg gaatcggaat
     1741 aaataaactt atataactta aaagcataaa atccttaagt aattataaaa aaaaaaaaaa
     1801 a
//
