LOCUS       NM_172473               3785 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus HECT domain and ankyrin repeat containing, E3
            ubiquitin protein ligase 1 (Hace1), mRNA.
ACCESSION   NM_172473
VERSION     NM_172473.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3785)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3785)
  AUTHORS   Turgu,B., El-Naggar,A., Kogler,M., Tortola,L., Zhang,H.F.,
            Hassan,M., Lizardo,M.M., Kung,S.H., Lam,W., Penninger,J.M. and
            Sorensen,P.H.
  TITLE     The HACE1 E3 ligase mediates RAC1-dependent control of mTOR
            signaling complexes
  JOURNAL   EMBO Rep 24 (12), e56815 (2023)
   PUBMED   37846480
  REMARK    GeneRIF: The HACE1 E3 ligase mediates RAC1-dependent control of
            mTOR signaling complexes.
REFERENCE   3  (bases 1 to 3785)
  AUTHORS   Turgu,B., Zhang,F., El-Naggar,A., Negri,G.L., Kogler,M.,
            Tortola,L., Johnson,F., Ng,T., Li,A., Yapp,D., Lockwood,W.,
            Martinez,D., Maris,J.M., Daugaard,M., Penninger,J.M., Hughes,C.S.
            and Sorensen,P.H.
  TITLE     HACE1 blocks HIF1alpha accumulation under hypoxia in a RAC1
            dependent manner
  JOURNAL   Oncogene 40 (11), 1988-2001 (2021)
   PUBMED   33603169
  REMARK    GeneRIF: HACE1 blocks HIF1alpha accumulation under hypoxia in a
            RAC1 dependent manner.
REFERENCE   4  (bases 1 to 3785)
  AUTHORS   Kogler,M., Tortola,L., Negri,G.L., Leopoldi,A., El-Naggar,A.M.,
            Mereiter,S., Gomez-Diaz,C., Nitsch,R., Tortora,D., Kavirayani,A.M.,
            Gapp,B.V., Rao,S., Uribesalgo,I., Hoffmann,D., Cikes,D.,
            Novatchkova,M., Williams,D.A., Trent,J.M., Ikeda,F., Daugaard,M.,
            Hagelkruys,A., Sorensen,P.H. and Penninger,J.M.
  TITLE     HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family
            GTPases
  JOURNAL   Cancer Res 80 (14), 3009-3022 (2020)
   PUBMED   32366477
  REMARK    GeneRIF: HACE1 Prevents Lung Carcinogenesis via Inhibition of
            RAC-Family GTPases.
REFERENCE   5  (bases 1 to 3785)
  AUTHORS   Ehrnhoefer,D.E., Southwell,A.L., Sivasubramanian,M., Qiu,X.,
            Villanueva,E.B., Xie,Y., Waltl,S., Anderson,L., Fazeli,A.,
            Casal,L., Felczak,B., Tsang,M. and Hayden,M.R.
  TITLE     HACE1 is essential for astrocyte mitochondrial function and
            influences Huntington disease phenotypes in vivo
  JOURNAL   Hum Mol Genet 27 (2), 239-253 (2018)
   PUBMED   29121340
  REMARK    GeneRIF: Authors show that the genetic ablation of hace1 in the
            YAC128 mouse model of HD accelerates motor deficits and exacerbates
            cognitive and psychiatric phenotypes in vivo.
REFERENCE   6  (bases 1 to 3785)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3785)
  AUTHORS   Daugaard,M., Nitsch,R., Razaghi,B., McDonald,L., Jarrar,A.,
            Torrino,S., Castillo-Lluva,S., Rotblat,B., Li,L., Malliri,A.,
            Lemichez,E., Mettouchi,A., Berman,J.N., Penninger,J.M. and
            Sorensen,P.H.
  TITLE     Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH
            oxidase complexes
  JOURNAL   Nat Commun 4, 2180 (2013)
   PUBMED   23864022
  REMARK    GeneRIF: Hace1 controls ROS generation of vertebrate Rac1-dependent
            NADPH oxidase complexes.
REFERENCE   8  (bases 1 to 3785)
  AUTHORS   Matsubara,S., Takahashi,T. and Kimura,A.P.
  TITLE     Epigenetic patterns at the mouse prolyl oligopeptidase gene locus
            suggest the CpG island in the gene body to be a novel regulator for
            gene expression
  JOURNAL   Gene 465 (1-2), 17-29 (2010)
   PUBMED   20600704
REFERENCE   9  (bases 1 to 3785)
  AUTHORS   Zhao,J., Zhang,Z., Vucetic,Z., Soprano,K.J. and Soprano,D.R.
  TITLE     HACE1: A novel repressor of RAR transcriptional activity
  JOURNAL   J Cell Biochem 107 (3), 482-493 (2009)
   PUBMED   19350571
REFERENCE   10 (bases 1 to 3785)
  AUTHORS   Zhang,L., Anglesio,M.S., O'Sullivan,M., Zhang,F., Yang,G.,
            Sarao,R., Mai,P.N., Cronin,S., Hara,H., Melnyk,N., Li,L., Wada,T.,
            Liu,P.P., Farrar,J., Arceci,R.J., Sorensen,P.H. and Penninger,J.M.
  TITLE     The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor
            involved in multiple cancers
  JOURNAL   Nat Med 13 (9), 1060-1069 (2007)
   PUBMED   17694067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153847.7, AK042879.1 and AC135669.5.
            
            On Jan 7, 2010 this sequence version replaced NM_172473.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042879.1, AK156958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC153847.7         11859-11918         c
            61-520              AK042879.1         2-461
            521-521             AC135669.5         132164-132164       c
            522-3710            AK042879.1         463-3651
            3711-3785           AC135669.5         10140-10214         c
FEATURES             Location/Qualifiers
     source          1..3785
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.65 cM"
     gene            1..3785
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /note="HECT domain and ankyrin repeat containing, E3
                     ubiquitin protein ligase 1"
                     /db_xref="GeneID:209462"
                     /db_xref="MGI:MGI:2446110"
     exon            1..322
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..2976
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /EC_number="2.3.2.26"
                     /note="HECT-type E3 ubiquitin transferase HACE1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase HACE1"
                     /protein_id="NP_766061.2"
                     /db_xref="CCDS:CCDS23829.1"
                     /db_xref="GeneID:209462"
                     /db_xref="MGI:MGI:2446110"
                     /translation="MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHR
                     SVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPL
                     HLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVE
                     DAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLL
                     RGAKYLPDKNGVTPLDLCVQGGYGQTCEVLIQYHPRLFQTIVQMTQNEDLRENMLRQV
                     LQHLSQQSESQYLKILTGLAEVATTNGHKLLSLSSNYDAQMKSLLRIVRIFCHVFRIG
                     PSSPSNGIDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLIATELMKNKEDSTDITSIL
                     LKQKGQDQEAPSLSAFEPPGPGSYESLPPGPGDSKPEVLAGEQEASADCQDVISVTAN
                     RLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLEC
                     PELMSRFMHIIKAQPFKDRCEWFYEHLHSGQPDSDMVHRPVSENDILLVHRDSIFRSS
                     CEIVSKANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSADGTT
                     FQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVAS
                     IDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEY
                     VQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIK
                     NTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQ
                     NFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA"
     exon            323..377
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            378..467
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            468..572
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            573..648
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            649..780
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            781..863
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            864..960
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1062
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1169
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1320
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1655
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1724
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1812
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1924
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2022
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2110
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2260
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2457
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2589
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2688
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2759
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2873
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3785
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3578..3583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3599
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /note="major polyA site"
     regulatory      3687..3692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3712
                     /gene="Hace1"
                     /gene_synonym="1700042J16Rik; A730034A22Rik"
ORIGIN      
        1 gagcccagga gggaagcggg gccgcggcag gaaaggcgcg agcgagcgga ggcggcggct
       61 ggtgcccacc ccagcgcggt ctggttggca gccgtcggtg cggcggactg actcggctta
      121 gcatcctagc gttcctgggc gccggccgca gcgagctcgc tccttctccc ggcctgtgcg
      181 gggatgtagg gcgcgggtcg cggaggccgc gggcgcggcg ggggcttcgc ggaggccgcg
      241 ccgaggatgg agagagcgat ggagcagctc aaccgtctga cgcgctcgct gcgccgcgcg
      301 cgcaccgtgg agctgcccga ggataatgag actgctgttt acacactgat gccaatggtg
      361 atggccgacc agcacaggtc tgtttctgaa ctcctatcaa attcaaaatt tgatgtcaat
      421 tatgcattcg gacgtgtgaa gagaagcttg cttcacattg ctgcaaactg tggatctgtg
      481 gaatgcttgg ttcttctgtt gaagaaaggc gcaaacccta actatcaaga tatttcaggc
      541 tgtacacccc ttcatctcgc tgctagaaat ggacagaaga aatgcatgag taaattactg
      601 gagtacagtg cggatgtcaa catttgtaat aatgaaggcc ttacagcaat acactggctg
      661 gctgtgaatg ggaggacaga gctcctccat gacctcgtgc aacacgtcac agatgtggat
      721 gtggaggatg ccatggggca gacagcgcta cacgtagcct gccagaacgg gcacaaaacg
      781 acagtgcagt gcttgctaga cagcggtgct gatattaaca ggccgaatgt atcaggagcc
      841 acgccactgt actttgcttg cagtcatggt cagagagata ctgcacagat tcttctatta
      901 cgaggagcca aatatttacc agataaaaat ggagtaaccc ctctagatct atgtgtacag
      961 ggtggttacg gacagacttg tgaagtgtta attcagtacc acccgaggct tttccagact
     1021 attgttcaaa tgacacagaa tgaagacctt cgggaaaaca tgttacggca agttctgcag
     1081 catttgtctc agcaaagtga aagccagtac ctaaagatcc tgacaggcct tgctgaagtt
     1141 gctacgacaa atggccataa gctgcttagt ttatctagca attatgatgc gcagatgaag
     1201 agccttttga ggattgtgag gatattttgt catgtctttc gaattggtcc ctcatctccc
     1261 agtaatggaa tcgatatggg ctacaatgga aataaaactc caagaagcca ggtgttcaag
     1321 cctttggaat tgctttggca ctcattggat gaatggttag ttttaatagc cacagaatta
     1381 atgaaaaaca aagaggattc aacagatatt acttctatct tgctgaaaca aaaaggccag
     1441 gatcaagagg ccccttctct ttctgcattt gagccaccag gccctgggag ctatgaaagc
     1501 ctgccccctg gtccagggga ctccaagcca gaggtgcttg caggggagca ggaagccagt
     1561 gccgactgtc aagacgtcat ctctgtgaca gccaaccggc tgagtgctgt cattcaagcc
     1621 ttctacatgt gctgttcctg tcagatgcct ccaggaatga cttcacctcg tttcattgag
     1681 tttgtctgca agcatgatga agtattgaaa tgctttgtga atagaaaccc caaaattata
     1741 tttgaccatt ttcactttct tcttgaatgt cctgaattga tgtcaagatt catgcatatc
     1801 ataaaagcac agccatttaa agatcgatgt gagtggttct atgaacatct gcactcagga
     1861 cagccggact cagacatggt ccacagacca gtgagtgaga acgatatcct cctggttcac
     1921 agagattcta tttttaggag tagctgtgaa attgtatcaa aagcaaactg tgcaaagcta
     1981 aagcagggga ttgctgtacg atttcatgga gaagaaggca tgggtcaagg cgttgtgcgt
     2041 gaatggtttg atattctgtc taatgagatc gtcaaccctg actatgcact gttcacccag
     2101 tcagcagacg gaacaacttt ccagcccaac agcaactcct atgtcaatcc tgatcacttg
     2161 aactatttcc ggtttgctgg acagatcttg gggttagctt tgaaccacag gcagctggtc
     2221 aatatttact tcacacgatc attctacaag cacattctcg gtattcctgt aaattaccaa
     2281 gatgtagcat ctattgatcc tgaatatgcc aaaaatttgc aatggatttt agataatgat
     2341 attagtgact tgggtctaga attgactttt tctgttgaga ctgatgtatt tggagctatg
     2401 gaagaggtgc ctttaaagcc tgggggtgga agtattcttg tgacacaaaa taacaaagcg
     2461 gagtatgtcc agctcgttac tgaactgcgt atgacaagag ccattcagcc gcagatcaat
     2521 gcgtttttac agggttttca tatgttcatc ccgccttccc tcatacaact gtttgacgag
     2581 tatgaattgg agctactgct ttctggcatg ccggaaattg atgtaaatga ttggataaaa
     2641 aatacagaat acacaagtgg ctatgaaaga gaagatccag ttattcagtg gttctgggaa
     2701 gttgtggaag acattactca agaagaaaga gttcttctct tgcagttcgt tactggcagt
     2761 tccagggtcc cgcatggtgg ctttgccaat attatgggtg gaagtggttt gcaaaacttt
     2821 acaattgctg ctgtgccata tactccaaat cttttaccaa cttccagcac atgcatcaac
     2881 atgctcaagt tacctgaata cccaagtaaa gaaatactca aggacagact ccttgtagca
     2941 ctgcattgtg gcagctatgg ttatacaatg gcataatgaa gcctggaaga ctcatctgcg
     3001 actgatgcac aatccagagt gacagaagta atttaggcag ctgtcagaaa ggcagcctcg
     3061 cctcgaccca caggcagaga gtgcctgctt aaaattcata acgaatcagg ttttctattt
     3121 tacatttctt ttccatgttt tgtttttcta tgtttgtgat acaattagaa aatataaaat
     3181 catagtagac ttcatttttt aaaatgctaa ttggaagtag acactttttt ttttaggttt
     3241 ctttaatctt atctaaaact cttaagacaa actcttttcc tgcattccac ctctgctgtg
     3301 acgctgtcta gttgaaaggg catttgctgt aaattatatg aggacatcca gctggtgtgt
     3361 tctatcgcat gtaaagtacc atttatattt tggaaaaatg taaagaatgg attaatttag
     3421 attgtgtaaa gccataaata tgtattttcc cacgttatac ttatattgca atgggtttta
     3481 tttttttgtt gttgtttagc tttttagtat tttgatacat ggtataaagt ttagactggt
     3541 atgccgaaca acggataaag tgatatataa tttatatatt aaagcttaca ctatatgaat
     3601 tatttgcatc tttctgtgct cagtttcatg tgtgtgtata tattctgtgt ggtctcagtt
     3661 tttcttatgc cttaatttat actgaaaata aaattaaaat atatttatct tatatttctt
     3721 tatttgatct aagcttgatg acacacttga agtaatataa tctgcagatt aaaacttaaa
     3781 tatgt
//
