LOCUS       NM_021345               2738 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 3-hydroxyacyl-CoA dehydratase 3 (Hacd3), mRNA.
ACCESSION   NM_021345
VERSION     NM_021345.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Blondelle,J., Ohno,Y., Gache,V., Guyot,S., Storck,S.,
            Blanchard-Gutton,N., Barthelemy,I., Walmsley,G., Rahier,A.,
            Gadin,S., Maurer,M., Guillaud,L., Prola,A., Ferry,A.,
            Aubin-Houzelstein,G., Demarquoy,J., Relaix,F., Piercy,R.J.,
            Blot,S., Kihara,A., Tiret,L. and Pilot-Storck,F.
  TITLE     HACD1, a regulator of membrane composition and fluidity, promotes
            myoblast fusion and skeletal muscle growth
  JOURNAL   J Mol Cell Biol 7 (5), 429-440 (2015)
   PUBMED   26160855
REFERENCE   3  (bases 1 to 2738)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   4  (bases 1 to 2738)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2738)
  AUTHORS   Olesen,C., Nyeng,P., Kalisz,M., Jensen,T.H., Moller,M., Tommerup,N.
            and Byskov,A.G.
  TITLE     Global gene expression analysis in fetal mouse ovaries with and
            without meiosis and comparison of selected genes with meiosis in
            the testis
  JOURNAL   Cell Tissue Res 328 (1), 207-221 (2007)
   PUBMED   17431699
REFERENCE   6  (bases 1 to 2738)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2738)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2738)
  AUTHORS   Courilleau,D., Chastre,E., Sabbah,M., Redeuilh,G., Atfi,A. and
            Mester,J.
  TITLE     B-ind1, a novel mediator of Rac1 signaling cloned from sodium
            butyrate-treated fibroblasts
  JOURNAL   J Biol Chem 275 (23), 17344-17348 (2000)
   PUBMED   10747961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ176979.1, AK159494.1 and CX209453.1.
            
            On Mar 28, 2008 this sequence version replaced NM_021345.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031755.1, AK052865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CJ176979.1         1-34
            35-2731             AK159494.1         1-2697
            2732-2738           CX209453.1         446-452
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.03 cM"
     gene            1..2738
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /note="3-hydroxyacyl-CoA dehydratase 3"
                     /db_xref="GeneID:57874"
                     /db_xref="MGI:MGI:1889341"
     exon            1..261
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1263
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /EC_number="4.2.1.134"
                     /note="protein tyrosine phosphatase-like protein PTPLAD1;
                     butyrate-induced protein 1; protein-tyrosine
                     phosphatase-like A domain-containing protein 1;
                     butyrate-induced transcript 1; very-long-chain
                     (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3;
                     protein tyrosine phosphatase-like A domain containing 1"
                     /codon_start=1
                     /product="very-long-chain (3R)-3-hydroxyacyl-CoA
                     dehydratase 3"
                     /protein_id="NP_067320.2"
                     /db_xref="CCDS:CCDS23284.1"
                     /db_xref="GeneID:57874"
                     /db_xref="MGI:MGI:1889341"
                     /translation="METQVLTPHVYWAQRHRELYLRVELSDVQNPAISITDNVLHFKA
                     QGHGAKGDNVYEFHLEFLDLVKPEPAYRLTQRQVNITVQKKGSHWWERLTKQEKRPLF
                     LAPDFDRWLDESDAEMELRAKEEERLNKLRLEREGSPETLTNLKKGYLFMYNLVQLLG
                     FSWIFVNLTVRFFILGKESFYDTFHNVADMMYFCQMLALVETLNAAIGVTSTPVLPAL
                     IQFLGRNFILFLVFGTMEEMQNKAVVFFVFYSWSAIEIFRYPFYMLSCIDMDWKVLTW
                     LRYTMWIPLYPLGCLSEAVAVIQSIPVFNESGRFSFTLPYPVKMKVRFSFFLQVYLVM
                     LFLGLYINFRHLYKQRRRRYGQKKKKLH"
     exon            262..304
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..378
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..543
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..595
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..706
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..834
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..947
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1054
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1186
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..2733
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2706..2711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /note="hexamer: ATTAAA"
     polyA_site      2733
                     /gene="Hacd3"
                     /gene_synonym="4930523M17Rik; B-ind1; Hcad3; Hspc121;
                     Ptplad1"
                     /note="major polyA site"
ORIGIN      
        1 ggtcctcact gcgcaagcgc gagccgcgag cgtgggttat ctcgagacag ccgggctgcg
       61 ggctgcggag cgtgcgggtc tgaggcctgc gttctgctag ctccagcggc tcacaggccg
      121 aggtaacgag gcgcagcaag ccgagcctcc ccgctccccc ggacagcgtg ggccatggag
      181 actcaagtgc tgacgccgca tgtctactgg gctcagcgac accgcgagct gtatctgcgc
      241 gtggagctga gtgacgtgca gaaccctgct atcagcatca cagacaatgt gctgcatttc
      301 aaagctcagg gacacggtgc caaaggagac aatgtctatg aatttcacct ggagttctta
      361 gaccttgtga agccagagcc ggcgtacagg ctgacccaga ggcaggtgaa catcacagtc
      421 cagaagaagg ggagtcattg gtgggaaaga ctcaccaagc aagagaagcg cccattgttt
      481 ttggcccctg actttgatcg ctggctggat gaatctgatg cggaaatgga gctgagagcc
      541 aaggaggaag aacgcctaaa taaactcaga ctagaaaggg aaggctcccc tgaaactctt
      601 acaaacttga agaaagggta cctgttcatg tacaaccttg tgcagctcct ggggttctcc
      661 tggatctttg tcaacctcac agtgcggttc tttattttag gaaaagagtc cttctatgac
      721 acgttccaca atgtggctga catgatgtat ttctgccaga tgctggcact agtggaaacc
      781 ctcaatgctg cgattggggt cacaagtacc ccggtgctac ctgctctcat ccagtttctt
      841 ggaagaaatt ttattctgtt tcttgttttc ggcaccatgg aagaaatgca aaacaaagct
      901 gtggttttct ttgtgtttta ttcctggagc gcaattgaaa tcttcaggta tcccttctac
      961 atgctctcct gcattgacat ggactggaag gtgctcacgt ggctccgtta cactatgtgg
     1021 attccgttat atcccctggg atgtttgtca gaagctgtgg cagtgatcca gtccattcca
     1081 gtattcaacg agtcgggaag gttcagtttt actttgccat atccagtgaa gatgaaagtc
     1141 agattttcct tcttccttca agtttatctc gtaatgttat ttttagggtt atatattaat
     1201 tttcgtcacc tttataaaca gcgcaggagg cggtatggac aaaagaagaa aaagctccac
     1261 taaagatgaa tttggtagct tcatttgagc agagtctatg attcctactc ttctacttct
     1321 tgtactgata taagggtttg ttttgttttg ttttttaaag taaggctgtc tctctttccc
     1381 agtaacattc ctgagtctac tgtccttatc ttagtgttgt acttgcatga catggatatc
     1441 tggtatctga ggacaagttc attcttgtgt atttaataac aaaggtggcc ctcttcatgt
     1501 ctgctcctcc ctacaggcac tgtctgtctt cacagggctt ggtctttctg ctgccacttg
     1561 tgaaaaccga aaaaaaacaa gactacatag caccgacttt ttgaaaatca gataaacatg
     1621 gttattgaca ttttttgagt cagagtaggg ctggagaaca cttcatattt gatgcctttt
     1681 agctaaagac attcattact atagcacttc ccaggcattg aagaggcaga gtgatttaga
     1741 gaacgaaatc agaacctggg aacaccatga ctacttcatt tctagctaaa tcagaactgc
     1801 cttcaacact ggagaaaggg agaagtactg cgcaacagag attagaagtc caaatgtgaa
     1861 tggctgcagg ggtcagaagg gaacagagat gcaggagaca ggcaggatca gttgtggtaa
     1921 tgatgcctgt ggcaaacaca aacacctact tgggctgcac acagtcacac aatcaatcta
     1981 taattcttgg ggttagctca gtccatttac ttgtgtattt ctgagtggtt ggtgagatta
     2041 ctttattgaa ctgttttttt ccttgttaga tttttttttc tctttttttg ttttttaaga
     2101 tagggttgtt ctgtgtagct ttggctctcc tagaacttgc tctgtagacc aggctggcct
     2161 tgaacacaga aagagattca tctgcctctg cctcctgagt gctgggatta aaggcaaaag
     2221 ccaccacagc ctgttttgtt ttgttttcgg tttaaaaaca acaacaaact gtgtgcatgc
     2281 agaatacaga ccttgaggtt ggctactgtt caagacagct tcagtctctc taccacattc
     2341 catgtaaacc tatggtgaag taacaccaga aaaaagagcc tgagagtggt cgcttccatc
     2401 ttccactccc cttgttcttg gggggaaagg aaggagactt ctgctgttgc agtgagccca
     2461 gagtggattg gcattaaact ggctgctttg acacacctca tctcacccaa gagtatttcc
     2521 caagtctgca gcttccgtca gcgattgttg tgttaccttc tggtgttccc tcactgattg
     2581 tggacaaacc tggcagttga gctttgcagt caattatgcc gtatccctgt gcaaactccc
     2641 atgttctagt tgctgttagc atcccctttg ttgctgtctg agaaagtgaa agattgtgta
     2701 tttctattaa aacatttaca gtcaaaatcc taaaaaaa
//
