LOCUS       NM_023587               3603 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus 3-hydroxyacyl-CoA dehydratase 2 (Hacd2), mRNA.
ACCESSION   NM_023587 XM_489550
VERSION     NM_023587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3603)
  AUTHORS   Khadhraoui,N., Prola,A., Vandestienne,A., Blondelle,J.,
            Guillaud,L., Courtin,G., Bodak,M., Prost,B., Huet,H.,
            Wintrebert,M., Pechoux,C., Solgadi,A., Relaix,F., Tiret,L. and
            Pilot-Storck,F.
  TITLE     Hacd2 deficiency in mice leads to an early and lethal mitochondrial
            disease
  JOURNAL   Mol Metab 69, 101677 (2023)
   PUBMED   36693621
  REMARK    GeneRIF: Hacd2 deficiency in mice leads to an early and lethal
            mitochondrial disease.
REFERENCE   2  (bases 1 to 3603)
  AUTHORS   Wei,L., Weng,S., Lu,X., Zhu,S., Yang,Q. and Chen,Y.Q.
  TITLE     3-Hydroxyacyl-CoA dehydratase 2 deficiency confers resistance to
            diet-induced obesity and glucose intolerance
  JOURNAL   Biochem Biophys Res Commun 605, 134-140 (2022)
   PUBMED   35325655
REFERENCE   3  (bases 1 to 3603)
  AUTHORS   Blondelle,J., Ohno,Y., Gache,V., Guyot,S., Storck,S.,
            Blanchard-Gutton,N., Barthelemy,I., Walmsley,G., Rahier,A.,
            Gadin,S., Maurer,M., Guillaud,L., Prola,A., Ferry,A.,
            Aubin-Houzelstein,G., Demarquoy,J., Relaix,F., Piercy,R.J.,
            Blot,S., Kihara,A., Tiret,L. and Pilot-Storck,F.
  TITLE     HACD1, a regulator of membrane composition and fluidity, promotes
            myoblast fusion and skeletal muscle growth
  JOURNAL   J Mol Cell Biol 7 (5), 429-440 (2015)
   PUBMED   26160855
REFERENCE   4  (bases 1 to 3603)
  AUTHORS   Uwanogho,D.A., Hardcastle,Z., Balogh,P., Mirza,G., Thornburg,K.L.,
            Ragoussis,J. and Sharpe,P.T.
  TITLE     Molecular cloning, chromosomal mapping, and developmental
            expression of a novel protein tyrosine phosphatase-like gene
  JOURNAL   Genomics 62 (3), 406-416 (1999)
   PUBMED   10644438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154230.2 and AK148143.1.
            
            On Jan 13, 2006 this sequence version replaced NM_023587.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148143.1, SRR1660811.235696.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC154230.2         11624-11637
            15-775              AK148143.1         1-761
            776-3603            AC154230.2         95551-98378
FEATURES             Location/Qualifiers
     source          1..3603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 24.54 cM"
     gene            1..3603
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /note="3-hydroxyacyl-CoA dehydratase 2"
                     /db_xref="GeneID:70757"
                     /db_xref="MGI:MGI:1918007"
     exon            1..215
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /inference="alignment:Splign:2.1.0"
     exon            216..333
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /inference="alignment:Splign:2.1.0"
     exon            334..352
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /inference="alignment:Splign:2.1.0"
     exon            353..441
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /inference="alignment:Splign:2.1.0"
     exon            442..563
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /inference="alignment:Splign:2.1.0"
     exon            564..742
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /inference="alignment:Splign:2.1.0"
     exon            743..3603
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      983..988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /note="hexamer: AATAAA"
     polyA_site      1006
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /note="major polyA site"
     regulatory      3581..3586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /note="hexamer: AATAAA"
     polyA_site      3601
                     /gene="Hacd2"
                     /gene_synonym="6330408J20Rik; Hcad2; Ptplb"
                     /note="major polyA site"
ORIGIN      
        1 gtagagccca gttgggtctg aggtgcaggc gcgaggggag cggggttgcg ggcgcttgac
       61 atggcggcag cggcggcgac tgcagcgacc aaggggaatg ggggcggcag tggccgagtc
      121 ggggctggcg acagcagcgg cgcgcggaag aagaagggcc ccgggcctgt ggccacggcg
      181 tacctggtca tctacaatgt ggtgatgacg gcggggtggc tggtgatagc agttgggctg
      241 gtgagagcat acctggctaa ggggagctac catagccttt attattcaat agaaaggcct
      301 ttgaagttct tccagacagg agccttactg gagattttac attgtgctat agggattgtg
      361 ccatcttctg ttgtcctgac ttctttccag gtgatgtcaa gagttttcct aatatgggca
      421 gtgacacata gtgtcaaaga ggtgcagagt gaagacagtg tacttctgtt tgtcattgcc
      481 tggacaatca cggaaattat ccgttactcc ttttacacat tcagtctatt aaaccatctg
      541 ccttatatca tcaaatgggc caggtacaca cttttcatcg tgctgtaccc aatgggagtg
      601 acaggagagc tcctcacaat atacgcagct ctgccctttg tccggcaggc cggcctgtac
      661 tccatcagct tacctaacaa atacaacttc tcctttgatt accatgcatt cctgattctg
      721 atcatgatct cctacattcc actgttcccc cagttgtact tccacatgat acaccagaga
      781 agaaaggtcc tttctcacac cgaagaacat aagaagtttg agtagcgctc cacaccaccc
      841 caaaccagac ttttcaatga tcaaaatatg ctgcagactt tttgagttcc cagtaagaac
      901 tatttttaaa atattaaata taaaacaaaa taaaaaacca aaatccagtg tcacacaggc
      961 ctgggatttt ataaaaaata aaaataaaaa gattaaaaat gcaaaagtct gttacataaa
     1021 gcatcctagc tggtcctttc agcatgctct gaccagaagt tgccagttcc tatgatggcg
     1081 ctagaagggg gttggccttt atcttctgtg tgtcctccat tcatctggca gtacagaatg
     1141 tacacccagt gccaagagct gccgtctgag gggcaaccgt gctccaactg acttcgcggc
     1201 ttgcagcaga agctgggttg cagtctgcgg tgtggctaac tttccccttc tcagagtgct
     1261 tgagtgcatg ctggaaactg ctcaggaatg ctctgaagtt ctggctagga cttagcccct
     1321 catatctagt gaatgcgtta caaaacgtat atggctgtga agctttgggg agtgcctgta
     1381 accagaaaac cactaaaagc ctttcatttg tttttgattc agtcgttgct gcctgccgct
     1441 gagatccgtg cttgaactta gtaagcctgt gtaaactata aagacccttg tgtggaactc
     1501 ggcttcagtc agattctaac aagccacggt gagggggaga gctgggtgcc tgggaagtgc
     1561 cttccatgta gcttcctcag agcacaaatg tactggccag caagagcctt gctgacagac
     1621 tcaaagcctg tctcatcaca caggaggagg aaatctgtaa ttaaaggccc ttgggaaggc
     1681 ttgctttacc accatggtcc acagaaggca ttcagagata gatttatact tactttttat
     1741 tttacttttt tactcttctg tttaggtatc tttcctgatt gtgttcctgt gtaattctca
     1801 ctaagttgta agtccagaga caagatgtgt tctaggaaaa gccaaaggta gtactgtccc
     1861 ctccacgcat cacagcagct gccagctgct tgtcaatagc cctgtctgac agtgtcttca
     1921 cagcacttcc ttgctcacct gtgtattaaa gtcctcttag gataggcttg gaggagacag
     1981 gcaaagccga ggcccaccca gctcacagct cccaaagtgc gcacggcaaa ctccttttga
     2041 aaacagaaag caaggttcgg atgaatgcca ggaccaagtt tagattgtgc tcgattttaa
     2101 ccagtccctt ctgaataggc tctctcccct cacttgcttt ctttttcttt ccttttttgt
     2161 ttatctttaa gactttaaaa atcttgccat tgtcatttag aatataattg ttccaatcag
     2221 aagaatataa tgaaaactac attttcaaat gcatattttc ataggagctt gaagagctaa
     2281 tgcaggcagg tgtgtaataa gttattgtca aactgaacat tagaattctg cttcaagtca
     2341 gctctcttga cttggctgtg tcaaaatcag aatctattct ggtatttggt agacaaatat
     2401 gtgggaaata tgtcttttca accttttctc cctttttatt cctccaaact gtattgcttc
     2461 tgtgaaacag aattagcttg ggtttcgtcc gcctttttac tgtagctgag attgttacca
     2521 ttgcgttgga atgcccacag aaggtggcct gaagcagatc atgcagcccg agagacccct
     2581 gggcctgcct tcctcactgc tacatctgga tcgcatcaga ctgagctgca ctgaggagaa
     2641 cacagtcacc agtttccctc acagacaggg tctcaatcca gtgcctgctt gacatgtgct
     2701 ctaagatgca gcagacagca gggtgtcctt ctgtcccctc tcgggagctg gctgttaggt
     2761 ctttttcatc cctaacatga tttgatttct ctgttgaggt aatcatgttc ttttacaaac
     2821 tgagaacatc cagcctcctc aggtgtgaca tctaatgagg tgtgagcacg gaaggttctt
     2881 tttttcagtg gctcttttgt cagaactaga gtcagccatc accctcgcag caaccacctg
     2941 actgcaggtc agatctcccc caggggccct ctgccaaagg gacagagtct ttgaggtgca
     3001 caggggccct ctgtagactt gtatggctaa tctgcgtcat gctgaggctg ggaccaccat
     3061 cataaaggcc ccacggagtt agtcatggag taaagcactg tcctcccaga caggaaagtc
     3121 taaagcaaac tgagcaagag gacagtgtgg atggtgcccg gccagaaaga caggaggcaa
     3181 ccgtgccttg cttttcactt gtgttggctt tacatttcta ttaaaagcct ggtgttgctg
     3241 aggtccaacc tgaaaaccat actcagttct gagtttcaga taaaccatta taaaacatca
     3301 aagtcactac acactgctcc tttgaaattt gggtaaaaaa attatacaac catatatata
     3361 gtcattttgt attttttcta tgttgtgaaa accaaaattg taattttata agtctttgat
     3421 tcactaaaat tatataattt aaatgtattt tttgtatatt taggaataag gagctcaaaa
     3481 actatgctta actttctacg catgcacttg aaagctgttt ttatctgata ttaatgtagt
     3541 aagttatact cataaaacac tgatacatgt tgcattccaa aataaattgg tgtgtgctct
     3601 gcc
//
