LOCUS       NM_013935               1015 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus 3-hydroxyacyl-CoA dehydratase 1 (Hacd1), transcript
            variant 1, mRNA.
ACCESSION   NM_013935
VERSION     NM_013935.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1015)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1015)
  AUTHORS   Prola,A., Blondelle,J., Vandestienne,A., Piquereau,J.,
            Denis,R.G.P., Guyot,S., Chauvin,H., Mourier,A., Maurer,M.,
            Henry,C., Khadhraoui,N., Gallerne,C., Molinie,T., Courtin,G.,
            Guillaud,L., Gressette,M., Solgadi,A., Dumont,F., Castel,J.,
            Ternacle,J., Demarquoy,J., Malgoyre,A., Koulmann,N., Derumeaux,G.,
            Giraud,M.F., Joubert,F., Veksler,V., Luquet,S., Relaix,F., Tiret,L.
            and Pilot-Storck,F.
  TITLE     Cardiolipin content controls mitochondrial coupling and energetic
            efficiency in muscle
  JOURNAL   Sci Adv 7 (1) (2021)
   PUBMED   33523852
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1015)
  AUTHORS   Sawai,M., Uchida,Y., Ohno,Y., Miyamoto,M., Nishioka,C., Itohara,S.,
            Sassa,T. and Kihara,A.
  TITLE     The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit
            functional redundancy and are active in a wide range of fatty acid
            elongation pathways
  JOURNAL   J Biol Chem 292 (37), 15538-15551 (2017)
   PUBMED   28784662
  REMARK    GeneRIF: Mutations in HACD1 can result in myopathies in humans;
            knockout mice lacking Hacd1 develop myopathic phenotypes. Data
            (including data from studies using knockout mice and cultured cells
            from knockout mice) suggest that HACD1 and HACD2 exhibit
            overlapping substrate specificities and thus appear to represent
            redundant activities in skeletal muscle.
REFERENCE   4  (bases 1 to 1015)
  AUTHORS   Blondelle,J., Ohno,Y., Gache,V., Guyot,S., Storck,S.,
            Blanchard-Gutton,N., Barthelemy,I., Walmsley,G., Rahier,A.,
            Gadin,S., Maurer,M., Guillaud,L., Prola,A., Ferry,A.,
            Aubin-Houzelstein,G., Demarquoy,J., Relaix,F., Piercy,R.J.,
            Blot,S., Kihara,A., Tiret,L. and Pilot-Storck,F.
  TITLE     HACD1, a regulator of membrane composition and fluidity, promotes
            myoblast fusion and skeletal muscle growth
  JOURNAL   J Mol Cell Biol 7 (5), 429-440 (2015)
   PUBMED   26160855
  REMARK    GeneRIF: Data reveal that HACD1 is a key regulator of a
            lipid-dependent muscle fibre growth mechanism.
            GeneRIF: Loss of function in myoblasts, knockout mice and
            spontaneously affected Labrador retrievers leads to reduced
            myoblast fusion (hypotrophy), associated with modified lipid
            composition and physical properties of membranes.
REFERENCE   5  (bases 1 to 1015)
  AUTHORS   Lin,X., Yang,X., Li,Q., Ma,Y., Cui,S., He,D., Lin,X., Schwartz,R.J.
            and Chang,J.
  TITLE     Protein tyrosine phosphatase-like A regulates myoblast
            proliferation and differentiation through MyoG and the cell cycling
            signaling pathway
  JOURNAL   Mol Cell Biol 32 (2), 297-308 (2012)
   PUBMED   22106411
  REMARK    GeneRIF: Ptpla regulates myogenesis through Myog.
            Erratum:[Mol Cell Biol. 2017 Jul 28;37(16):e00236-17. doi:
            10.1128/MCB.00236-17.. PMID: 28754770]
REFERENCE   6  (bases 1 to 1015)
  AUTHORS   Uwanogho,D.A., Hardcastle,Z., Balogh,P., Mirza,G., Thornburg,K.L.,
            Ragoussis,J. and Sharpe,P.T.
  TITLE     Molecular cloning, chromosomal mapping, and developmental
            expression of a novel protein tyrosine phosphatase-like gene
  JOURNAL   Genomics 62 (3), 406-416 (1999)
   PUBMED   10644438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK085898.1, AK010119.1 and BE633820.1.
            
            On Apr 14, 2007 this sequence version replaced NM_013935.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AK085898.1         2-158
            158-1000            AK010119.1         3-845
            1001-1015           BE633820.1         405-419
FEATURES             Location/Qualifiers
     source          1..1015
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 10.3 cM"
     gene            1..1015
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /note="3-hydroxyacyl-CoA dehydratase 1"
                     /db_xref="GeneID:30963"
                     /db_xref="MGI:MGI:1353592"
     exon            1..305
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..915
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /EC_number="4.2.1.134"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein-tyrosine phosphatase-like member A;
                     very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein]
                     dehydratase 1; very-long-chain (3R)-3-hydroxyacyl-CoA
                     dehydratase 1; protein tyrosine phosphatase-like (proline
                     instead of catalytic arginine), member a"
                     /codon_start=1
                     /product="very-long-chain (3R)-3-hydroxyacyl-CoA
                     dehydratase 1 isoform 1"
                     /protein_id="NP_038963.3"
                     /db_xref="CCDS:CCDS50505.1"
                     /db_xref="GeneID:30963"
                     /db_xref="MGI:MGI:1353592"
                     /translation="MASSEEDGTNGASEASDEKEAAGKRRRLGLLATAWLTFYNIAMT
                     AGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQTFALLEVVHCLIGIVPTSVLVTG
                     VQVSSRIFMVWLITHSIKPIQNEESVVLFLVSWTVTEITRYSFYTFSLLDHLPHFIKW
                     ARYNLFIILYPVGVAGELLTIYAALPYVKKSGMFSVRLPNKYNVSFDYYYFLLITMAS
                     YIPLFPQLYFHMLRQRRKVLHGEVIAEKDD"
     exon            306..423
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     exon            424..442
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     exon            443..531
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     exon            532..653
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     exon            654..832
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1008
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     regulatory      985..990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /note="hexamer: AATAAA"
     polyA_site      1008
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /note="major polyA site"
ORIGIN      
        1 gctcctcccc ctcgcgggag gccgggcagg cggcgccgac cccccgcgcg tcgcacatgg
       61 agcgctggac cgaggcggcg gccgcgggca gcggcacttc agtggcgcgc tcagccggcc
      121 cctcccgctc ctgtgcgctg ctcctccggg tccgcgtgcg cggtcaccat ggcgtccagt
      181 gaggaggacg gcaccaacgg cgcctccgag gccagcgacg agaaggaagc cgccggcaag
      241 cggagacgcc taggcttact ggccaccgcc tggctcacct tctacaatat cgccatgacg
      301 gccgggtggt tggttcttgc tattgctatg gtacgctttt atatggaaaa aggaacacac
      361 agaggtttat ataaaagcat tcagaagaca cttaagtttt tccaaacatt tgctttgctt
      421 gaggtagtcc attgtctgat cggaattgta cccacttctg tgcttgtgac tggggtccaa
      481 gtgagctcaa gaatcttcat ggtgtggctc attactcaca gtataaaacc catccagaat
      541 gaagagagcg tggtgctttt tctggtctcc tggactgtga ccgagatcac tcgctattcc
      601 ttctacacat tcagtctcct cgaccacttg ccgcacttca ttaaatgggc cagatacaat
      661 ttgtttatca tcttatatcc cgttggagtt gctggggaac ttctcacaat atacgccgcc
      721 ttgccttacg taaagaagtc aggaatgttc tcagtacggc ttcccaacaa gtacaatgtt
      781 tcttttgact actactattt tcttctcata accatggcct cctatatacc gttgtttcct
      841 cagctctatt ttcatatgtt acgtcagaga agaaaggtgc tccacgggga ggtgatcgcg
      901 gagaaggacg attaagtggt tcccacacac aaggtgctct tttcagaaaa accggattac
      961 ttgagtccaa gttttaataa taagaataaa cgacttcatg aaataccaaa aaaaa
//
