LOCUS       NM_001329935            2934 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript
            variant 1, mRNA.
ACCESSION   NM_001329935
VERSION     NM_001329935.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2934)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Zhao,L., Castillo,M., Xiao,Y., Guo,H.,
            Liu,Y., Gunaratne,P., Schwartz,R.J., Burns,A.R., Kumar,A.,
            DiPersio,C.M. and Wu,M.
  TITLE     beta1 integrins regulate cellular behaviour and cardiomyocyte
            organization during ventricular wall formation
  JOURNAL   Cardiovasc Res 120 (11), 1279-1294 (2024)
   PUBMED   38794925
REFERENCE   2  (bases 1 to 2934)
  AUTHORS   Kim,E.E., Shekhar,A., Ramachandran,J., Khodadadi-Jamayran,A.,
            Liu,F.Y., Zhang,J. and Fishman,G.I.
  TITLE     The transcription factor EBF1 non-cell-autonomously regulates
            cardiac growth and differentiation
  JOURNAL   Development 150 (21) (2023)
   PUBMED   37787076
REFERENCE   3  (bases 1 to 2934)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   4  (bases 1 to 2934)
  AUTHORS   Fernandez-Santos,B., Reyes-Corral,M., Caro-Vega,J.M., Lao-Perez,M.,
            Vallejo-Grijalba,C., Mesa-Cruz,C., Moron,F.J. and Ybot-Gonzalez,P.
  TITLE     The loop-tail mouse model displays open and closed caudal neural
            tube defects
  JOURNAL   Dis Model Mech 16 (8) (2023)
   PUBMED   37589570
REFERENCE   5  (bases 1 to 2934)
  AUTHORS   Luo,H., Huang,Q., Huang,D., Liu,C., Long,X. and Tang,R.
  TITLE     HABP2 Encapsulated by Peripheral Blood-Derived Exosomes Suppresses
            Astrocyte Autophagy to Exacerbate Neuroinflammatory Injury in Mice
            with Ischemic Stroke
  JOURNAL   ACS Chem Neurosci 14 (12), 2347-2361 (2023)
   PUBMED   37294185
  REMARK    GeneRIF: HABP2 Encapsulated by Peripheral Blood-Derived Exosomes
            Suppresses Astrocyte Autophagy to Exacerbate Neuroinflammatory
            Injury in Mice with Ischemic Stroke.
REFERENCE   6  (bases 1 to 2934)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 2934)
  AUTHORS   Hou,J., Charters,A.M., Lee,S.C., Zhao,Y., Wu,M.K., Jones,S.J.,
            Marra,M.A. and Hoodless,P.A.
  TITLE     A systematic screen for genes expressed in definitive endoderm by
            Serial Analysis of Gene Expression (SAGE)
  JOURNAL   BMC Dev Biol 7, 92 (2007)
   PUBMED   17683524
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2934)
  AUTHORS   Sedding,D., Daniel,J.M., Muhl,L., Hersemeyer,K., Brunsch,H.,
            Kemkes-Matthes,B., Braun-Dullaeus,R.C., Tillmanns,H., Weimer,T.,
            Preissner,K.T. and Kanse,S.M.
  TITLE     The G534E polymorphism of the gene encoding the factor
            VII-activating protease is associated with cardiovascular risk due
            to increased neointima formation
  JOURNAL   J Exp Med 203 (13), 2801-2807 (2006)
   PUBMED   17145954
REFERENCE   9  (bases 1 to 2934)
  AUTHORS   Choi-Miura,N.H., Takahashi,K., Yoda,M., Saito,K., Mazda,T. and
            Tomita,M.
  TITLE     Proteolytic activation and inactivation of the serine protease
            activity of plasma hyaluronan binding protein
  JOURNAL   Biol Pharm Bull 24 (5), 448-452 (2001)
   PUBMED   11379758
REFERENCE   10 (bases 1 to 2934)
  AUTHORS   Hashimoto,K., Tobe,T., Sumiya,J., Saguchi,K., Sano,Y., Nakano,Y.,
            Choi-Miura,N.H. and Tomita,M.
  TITLE     Cloning of the cDNA for a mouse homologue of human PHBP: a novel
            hyaluronan-binding protein
  JOURNAL   Biol Pharm Bull 20 (11), 1127-1130 (1997)
   PUBMED   9401717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161579.4, AK132407.1, BB569555.2 and AC115771.13.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128915.1, SRR5189682.92137.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC161579.4         186264-186273
            11-178              AK132407.1         2-169
            179-289             BB569555.2         162-272
            290-2444            AK132407.1         170-2324
            2445-2445           AC115771.13        91119-91119
            2446-2934           AK132407.1         2326-2814
FEATURES             Location/Qualifiers
     source          1..2934
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.79 cM"
     gene            1..2934
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /note="hyaluronic acid binding protein 2"
                     /db_xref="GeneID:226243"
                     /db_xref="MGI:MGI:1196378"
     exon            1..141
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1749
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /EC_number="3.4.21.92"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hyaluronan-binding protein 2; plasma hyaluronan-binding
                     protein; hyaduronic acid-binding protein 2"
                     /codon_start=1
                     /product="hyaluronan-binding protein 2 isoform 1"
                     /protein_id="NP_001316864.1"
                     /db_xref="CCDS:CCDS89419.1"
                     /db_xref="GeneID:226243"
                     /db_xref="MGI:MGI:1196378"
                     /translation="MLVFRVLLLIALVGKSVIGLSLMSFIAPPDPDWTPDDYYYSYEQ
                     SSPDEDPSVTQTTPENPDWYYEDDDPCQSNPCEHGGDCIIRGDTFSCSCPAPFSGSRC
                     QTAQNKCKDNPCVHGDCLITQKHPYYRCACKYPYTGPDCSKVLPACRPNPCQNGGVCS
                     RHRRRSRFTCACPDQYKGKFCEIGPDDCYVGDGYSYRGKVSKTVNQNPCLYWNSHLLL
                     QETYNMFMEDAETHGIAEHNFCRNPDGDHKPWCFVKVNSEKVKWEYCDVTVCPVPDTP
                     NPVESLLEPVMELPGFESCGKTEVAEHAVKRIYGGFKSTAGKHPWQVSLQTSLPLTTS
                     MPQGHFCGGALIHPCWVLTAAHCTDINTKHLKVVLGDQDLKKTESHEQTFRVEKILKY
                     SQYNERDEIPHNDIALLKLKPVGGHCALESRYVKTVCLPSDPFPSGTECHISGWGVTE
                     TGEGSRQLLDAKVKLIANPLCNSRQLYDHTIDDSMICAGNLQKPGSDTCQGDSGGPLT
                     CEKDGTYYVYGIVSWGQECGKKPGVYTQVTKFLNWIKTTMHREAGL"
     exon            142..178
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            179..289
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            290..397
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            398..514
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            515..634
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            635..806
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            807..904
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1160
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1303
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1438
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1584
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..2934
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2178..2183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /note="hexamer: AATAAA"
     polyA_site      2203
                     /gene="Habp2"
                     /gene_synonym="FSAP; HABP; HGFAL; PHBP"
                     /note="major polyA site"
ORIGIN      
        1 cccccacccc aaaggaatag acaagaagag aaactgcaga gggagagaac agagaggcct
       61 tcaactacac agatatttgt caggatgttg gtgttccgtg tcctgctgct aatcgccctg
      121 gtggggaagt cagtcattgg gctctcactg atgtccttca ttgcgccccc agacccagat
      181 tggacccccg atgactatta ctacagctat gagcagtcca gcccagacga agaccccagt
      241 gtcacgcaga ccacccctga gaaccccgac tggtactatg aagacgatga tccatgccag
      301 tccaacccct gtgaacacgg cggggactgt atcatcagag gggatacctt cagttgcagc
      361 tgcccagccc ccttctcggg gagccggtgc cagactgcac aaaacaagtg caaggacaac
      421 ccatgtgtcc atggtgattg cctcattacc cagaagcacc cctactaccg ctgtgcctgc
      481 aaataccctt acacgggacc agactgctcc aaagtgcttc cggcatgcag gccaaacccc
      541 tgccagaatg gcggagtctg ttcccgacac agacggagat ccaggtttac ctgtgcctgt
      601 ccagaccagt ataaggggaa attctgtgaa ataggtccgg acgactgtta tgtcggtgat
      661 ggctactctt accgaggcaa agtgagtaag acagtcaacc agaacccatg cctttactgg
      721 aactcccacc tcctcttgca ggagacttat aacatgttta tggaggatgc agagacccac
      781 gggatcgcag agcacaactt ctgcagaaac ccagatggag accacaaacc ctggtgtttc
      841 gtcaaggtga acagtgagaa ggtgaaatgg gaatactgtg atgtcacagt ctgtccagtg
      901 cctgacaccc ctaacccagt ggaaagcctt ctggagcctg tgatggagct gccagggttc
      961 gagtcctgcg ggaagacgga ggtagctgaa cacgcagtca agcgtatcta cgggggcttt
     1021 aagagcacag caggcaagca cccgtggcag gtgtccctgc agacctcact gccgttgacc
     1081 acctccatgc cccaaggcca cttctgtggg ggcgccctga tccacccctg ctgggtgctc
     1141 actgcagccc actgtaccga cataaacacc aagcatctaa aagttgtact aggggatcag
     1201 gacctgaaga agacagaatc ccatgaacag accttcaggg tggaaaaaat actgaagtac
     1261 agtcagtata atgaaagaga tgagattccc cacaatgaca ttgctttgct caagttaaag
     1321 ccagtgggtg gtcactgtgc tctggaatcc agatatgtga agactgtatg tttgcccagc
     1381 gacccctttc cctctggaac tgagtgccac atctctggct ggggtgttac agaaacaggg
     1441 gaagggtccc gccagctcct ggatgctaaa gtcaagctaa tcgctaaccc tttgtgcaac
     1501 tcccgacaac tctatgacca caccatcgat gacagtatga tttgtgcggg gaaccttcag
     1561 aagcccggat cagacacctg ccagggtgac tcggggggcc ctctaacctg tgagaaggat
     1621 ggaacttact acgtctacgg gattgtaagc tggggccagg aatgtgggaa gaagccagga
     1681 gtctacactc aagtcaccaa gttcctgaat tggataaaga ccaccatgca cagggaggct
     1741 ggcctctgag gtgctgtctg cagagccttg aagcccctcg tctttagcac caaacaagag
     1801 gggcttcctg cgtagccagg gatgtcctgg gtccatgctc tagacagagg cattgttgcc
     1861 cagcctgggc ctttccagac tggcactata tcatttcatg aggccttttc tctctgggaa
     1921 ccaacaagaa atacattatc tttgcccccg ttctgacaag tgtaccttct agataaccag
     1981 aattcagaga cgttctccac catggagact gcgaatctga gatccctgct tgccccgcac
     2041 caggagatgt ttccttgact ctttatcttt tgtccatacc atcagggtcc tccacagaac
     2101 cagccattct catgcagcca tcagagagaa gcccccaaaa ccacaagctc tttgtttgct
     2161 ttcagagttg ttattttaat aaaggcagat gtgggcacgg ggagggtgtg ccagtttttt
     2221 ttttttttta aaacactcgc tcatccagac caaagccaca gaggcatgcc tttggcaagc
     2281 agccctcaag ggggcttctt aaggaggctc acatcagcag agtcttcttc ttgtggatat
     2341 gcaggatctc cgaggcatcc gggttcaccc ccctgctctg atgatctcct agcgccgctg
     2401 ctgcctctgg ctccacctgc ggaagccaca catagcgccc cacctccact gagttcacag
     2461 gaaaccccgt tgctgctccc acaagccgtg ctaagatgcc cggcaaacat ctaacgagct
     2521 ccccacccct cctttgtcct ctcttccacc ccggtccaag aaaaaggatc ctcaaggcag
     2581 agatgagaag gaagcaaaac ctgcttctca tttagatgtg ctgtctctct cctgaacaaa
     2641 gtagggttca aaatgcagac tgctggagcc agcaagtccc tgaccctttc cgcgaatgta
     2701 acgagcaagc agtcagcaca gcctgggctg ccctggcccg ggattgatgt cgccctggta
     2761 ggtttgcctc tgcagaacta atggctgtga cttcagagga agcccgcggg aagtttaacc
     2821 caggtgtcat ccgcccggtc atctcagacc catgaaatta ggcgccttgt tcggctgcct
     2881 ttcacgcttc tttagaacta gctgaccttt ggccaaaaat aaactttgaa aagc
//
