LOCUS       NM_025325               1252 bp    mRNA    linear   ROD 13-AUG-2024
DEFINITION  Mus musculus 3-hydroxyanthranilate 3,4-dioxygenase (Haao), mRNA.
ACCESSION   NM_025325 XM_354652 XM_890647 XM_899123 XM_899160 XM_925482
            XM_925483 XM_986039 XM_986095 XM_988905 XM_988933 XM_988974
VERSION     NM_025325.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1252)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1252)
  AUTHORS   Dang,H., Castro-Portuguez,R., Espejo,L., Backer,G., Freitas,S.,
            Spence,E., Meyers,J., Shuck,K., Gardea,E.A., Chang,L.M., Balsa,J.,
            Thorns,N., Corban,C., Liu,T., Bean,S., Sheehan,S., Korstanje,R. and
            Sutphin,G.L.
  TITLE     On the benefits of the tryptophan metabolite 3-hydroxyanthranilic
            acid in Caenorhabditis elegans and mouse aging
  JOURNAL   Nat Commun 14 (1), 8338 (2023)
   PUBMED   38097593
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1252)
  AUTHORS   Maganin,A.G., Souza,G.R., Fonseca,M.D., Lopes,A.H., Guimaraes,R.M.,
            Dagostin,A., Cecilio,N.T., Mendes,A.S., Goncalves,W.A., Silva,C.E.,
            Fernandes Gomes,F.I., Mauriz Marques,L.M., Silva,R.L., Arruda,L.M.,
            Santana,D.A., Lemos,H., Huang,L., Davoli-Ferreira,M.,
            Santana-Coelho,D., Sant'Anna,M.B., Kusuda,R., Talbot,J.,
            Pacholczyk,G., Buqui,G.A., Lopes,N.P., Alves-Filho,J.C., Leao,R.M.,
            O'Connor,J.C., Cunha,F.Q., Mellor,A. and Cunha,T.M.
  TITLE     Meningeal dendritic cells drive neuropathic pain through elevation
            of the kynurenine metabolic pathway in mice
  JOURNAL   J Clin Invest 132 (23), e153805 (2022)
   PUBMED   36227694
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1252)
  AUTHORS   Cuny,H., Rapadas,M., Gereis,J., Martin,E.M.M.A., Kirk,R.B., Shi,H.
            and Dunwoodie,S.L.
  TITLE     NAD deficiency due to environmental factors or gene-environment
            interactions causes congenital malformations and miscarriage in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 117 (7), 3738-3747 (2020)
   PUBMED   32015132
REFERENCE   5  (bases 1 to 1252)
  AUTHORS   Kojima,Y., Koguchi,T., Mizuno,K., Sato,Y., Hoshi,S., Hata,J.,
            Nishio,H., Hashimoto,D., Matsushita,S., Suzuki,K., Miyagawa,S.,
            Hui,C.C., Tanikawa,C., Murakami,Y., Yamada,G., Hayashi,Y. and
            Matsuda,K.
  TITLE     Single Nucleotide Polymorphisms of HAAO and IRX6 Genes as Risk
            Factors for Hypospadias
  JOURNAL   J Urol 201 (2), 386-392 (2019)
   PUBMED   30063927
  REMARK    GeneRIF: In mouse embryos there was no significant upregulation of
            Haao expression in the developing male external genitalia. Irx6 was
            expressed in the ectodermal epithelium, demonstrating prominent
            dorsal ectodermal expression without expression in the ventral
            ectoderm adjacent to the urethral plate during the same period.
REFERENCE   6  (bases 1 to 1252)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1252)
  AUTHORS   Nakagawa,Y., Asai,H., Miura,T., Kitoh,J., Mori,H. and Nakano,K.
  TITLE     Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene
            in brain of epilepsy-prone El mice
  JOURNAL   Brain Res Mol Brain Res 58 (1-2), 132-137 (1998)
   PUBMED   9685612
REFERENCE   8  (bases 1 to 1252)
  AUTHORS   Eastman,C.L., Urbanska,E.M., Chapman,A.G. and Schwarcz,R.
  TITLE     Differential expression of the astrocytic enzymes
            3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase
            and glutamine synthetase in seizure-prone and non-epileptic mice
  JOURNAL   Epilepsy Res 18 (3), 185-194 (1994)
   PUBMED   7805640
REFERENCE   9  (bases 1 to 1252)
  AUTHORS   Nakano,K., Takahashi,S., Mizobuchi,M., Kuroda,T., Masuda,K. and
            Kitoh,J.
  TITLE     High levels of quinolinic acid in brain of epilepsy-prone E1 mice
  JOURNAL   Brain Res 619 (1-2), 195-198 (1993)
   PUBMED   8374778
REFERENCE   10 (bases 1 to 1252)
  AUTHORS   Nakano,K., Asai,H. and Kitoh,J.
  TITLE     Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase
            in brain of epilepsy-prone El mice
  JOURNAL   Brain Res 572 (1-2), 1-4 (1992)
   PUBMED   1611505
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC094021.1.
            
            On or before Jan 29, 2007 this sequence version replaced
            XM_899160.2, XM_890647.2, XM_354652.5, XM_899123.2, XM_986095.1,
            XM_925483.2, XM_925482.2, XM_986039.1, XM_988974.1, XM_988933.1,
            XM_988905.1, NM_025325.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012872.1, AK002608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1252
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 54.85 cM"
     gene            1..1252
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /note="3-hydroxyanthranilate 3,4-dioxygenase"
                     /db_xref="GeneID:107766"
                     /db_xref="MGI:MGI:1349444"
     exon            1..154
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..935
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /EC_number="1.13.11.6"
                     /note="HAD; 3-hydroxyanthranilate oxygenase;
                     3-hydroxyanthranilic acid dioxygenase"
                     /codon_start=1
                     /product="3-hydroxyanthranilate 3,4-dioxygenase"
                     /protein_id="NP_079601.1"
                     /db_xref="CCDS:CCDS37709.1"
                     /db_xref="GeneID:107766"
                     /db_xref="MGI:MGI:1349444"
                     /translation="MERRVRVKSWVEENRASFQPPVCNKLMHQEQLKIMFVGGPNTRK
                     DYHIEEGEEVFYQLEGDMILRVLEQGQHRDVPIRQGEIFLLPARVPHSPQRFANTMGL
                     VIERRRLESELDGLRYYVGDTEDVLFEKWFHCKDLGTQLAPIIQEFFHSEQYRTGKPN
                     PDQLLKELPFPLNTRSIMKPMSLKAWLDGHSRELQAGTSLSLFGDSYETQVIAHGQGS
                     SKGPRQDVDVWLWQQEGSSKVTMGGQCIALAPDDSLLVPAGTSYVWERAQGSVALSVT
                     QDPARKKPWW"
     exon            155..233
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /inference="alignment:Splign:2.1.0"
     exon            234..317
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /inference="alignment:Splign:2.1.0"
     exon            318..424
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /inference="alignment:Splign:2.1.0"
     exon            425..514
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /inference="alignment:Splign:2.1.0"
     exon            515..558
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /inference="alignment:Splign:2.1.0"
     exon            559..704
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /inference="alignment:Splign:2.1.0"
     exon            705..773
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /inference="alignment:Splign:2.1.0"
     exon            774..856
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1224
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1205..1210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /note="hexamer: AATAAA"
     polyA_site      1224
                     /gene="Haao"
                     /gene_synonym="0610007K21Rik; 0610012J07Rik; 3-HAO;
                     3-HAOxase; 3HAO"
                     /note="major polyA site"
ORIGIN      
        1 cgcagatcgc atcactccaa cctcccgatt acctggccac cacgttgtgg gcagaagagt
       61 cctgcctgcc ggccatggaa cgccgtgtga gagtgaagtc ttgggtagaa gagaatcggg
      121 cctcctttca gcctccggtt tgcaacaagc ttatgcacca ggagcagctc aaaatcatgt
      181 tcgttggagg ccccaatacc aggaaggatt atcacattga agagggtgag gaggtgtttt
      241 accagctgga gggagacatg atactacgag tcctggagca ggggcaacac cgggacgtgc
      301 ctatacggca gggagagata ttcctcctgc ctgccagggt gccccactcc ccgcagaggt
      361 ttgccaacac catggggctg gtgattgaga gaaggcggct ggagagcgag ctggatgggc
      421 tgaggtatta cgtgggggac actgaggatg tcctcttcga gaaatggttc cactgtaagg
      481 accttggcac gcagttagca cccatcatcc aagagttctt ccactctgag caataccgaa
      541 caggaaaacc caaccctgac cagctgctca aggagctgcc attcccgctg aatacacggt
      601 ccatcatgaa gcccatgtca ttgaaggcct ggctggatgg ccactccagg gagcttcagg
      661 caggcacatc cctaagcctg tttggggaca gctatgagac ccaggtcatt gcccacggac
      721 aaggtagcag caaaggccca aggcaggatg tggatgtgtg gctgtggcaa caggagggct
      781 cctctaaggt gacaatggga gggcagtgta tagccctggc cccagatgac agcctgctgg
      841 tgcctgctgg aacctcgtat gtgtgggagc gagcacaagg ctctgtggcc ttgtctgtga
      901 cacaagaccc tgcccgtaag aagccatggt ggtgaccctc ctgtgtgcgc cccaagcagc
      961 cacagggtgc ctgagtaatg acctggtagc tgcccatttc cagacagctc tttcagcctc
     1021 attgcatctc catggacatc agcaggcccc ttgagtggtt gagagctgtc actggcatca
     1081 accctcctgc ctagctcagc ccaggatgcc agactcctag gacatcagca gtccccgatc
     1141 ttctaacagc catagcccta cactgtcccc atgtgcccag cagcctgaca ctaagaaatc
     1201 tctcaataaa ggcatcctgc tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
