LOCUS       NM_001291004            4678 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus hexose-6-phosphate dehydrogenase (glucose
            1-dehydrogenase) (H6pd), transcript variant 2, mRNA.
ACCESSION   NM_001291004 XM_006537060 XM_006538460
VERSION     NM_001291004.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4678)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4678)
  AUTHORS   Wang,J., Wang,Y., Liu,L., Lutfy,K., Friedman,T.C., Liu,Y., Jiang,M.
            and Liu,Y.
  TITLE     Lack of adipose-specific hexose-6-phosphate dehydrogenase causes
            inactivation of adipose glucocorticoids and improves metabolic
            phenotype in mice
  JOURNAL   Clin Sci (Lond) 133 (21), 2189-2202 (2019)
   PUBMED   31696216
  REMARK    GeneRIF: reduction in adipose-specific H6PDH leads to reduced fat
            cell-specific production of glucocorticoids and decreased abdominal
            fat
REFERENCE   3  (bases 1 to 4678)
  AUTHORS   Tang,B.L.
  TITLE     Neuroprotection by glucose-6-phosphate dehydrogenase and the
            pentose phosphate pathway
  JOURNAL   J Cell Biochem 120 (9), 14285-14295 (2019)
   PUBMED   31127649
  REMARK    GeneRIF: Neuroprotection by glucose-6-phosphate dehydrogenase and
            the pentose phosphate pathway.
            Review article
REFERENCE   4  (bases 1 to 4678)
  AUTHORS   Liu,L., Wang,Y., Wang,J., Dong,Y., Chang,S., Liu,X., Lutfy,K.,
            Chen,H., Friedman,T.C., Jiang,M. and Liu,Y.
  TITLE     Enhanced hexose-6-phosphate dehydrogenase expression in adipose
            tissue may contribute to diet-induced visceral adiposity
  JOURNAL   Int J Obes (Lond) 42 (12), 1999-2011 (2018)
   PUBMED   29568102
  REMARK    GeneRIF: Studied expression levels and signal pathways involved
            with hexose-6-phosphate dehydrogenase in mouse model of diet
            induced visceral adiposity.
REFERENCE   5  (bases 1 to 4678)
  AUTHORS   Zielinska,A.E., Fletcher,R.S., Sherlock,M., Doig,C.L. and
            Lavery,G.G.
  TITLE     Cellular and genetic models of H6PDH and 11beta-HSD1 function in
            skeletal muscle
  JOURNAL   Cell Biochem Funct 35 (5), 269-277 (2017)
   PUBMED   28749080
  REMARK    GeneRIF: We envisage these data and models finding utility when
            investigating the muscle-specific functions of the
            11beta-HSD1/G6PT/H6PDH triad.
REFERENCE   6  (bases 1 to 4678)
  AUTHORS   Morse,H.C. 3rd, Chused,T.M., Hartley,J.W., Mathieson,B.J.,
            Sharrow,S.O. and Taylor,B.A.
  TITLE     Expression of xenotropic murine leukemia viruses as cell-surface
            gp70 in genetic crosses between strains DBA/2 and C57BL/6
  JOURNAL   J Exp Med 149 (5), 1183-1196 (1979)
   PUBMED   221612
REFERENCE   7  (bases 1 to 4678)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics and ontogeny of aldehyde dehydrogenase isozymes in the
            mouse: localization of Ahd-1 encoding the mitochondrial isozyme on
            chromosome 4
  JOURNAL   Biochem Genet 16 (11-12), 1207-1218 (1978)
   PUBMED   751648
REFERENCE   8  (bases 1 to 4678)
  AUTHORS   Taylor,B.A., Bedigian,H.G. and Meier,H.
  TITLE     Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in
            recombinant inbred lines
  JOURNAL   J Virol 23 (1), 106-109 (1977)
   PUBMED   196096
REFERENCE   9  (bases 1 to 4678)
  AUTHORS   Chapman,V.M.
  TITLE     6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse:
            linkage with metabolically related enzyme loci
  JOURNAL   Biochem Genet 13 (11-12), 849-856 (1975)
   PUBMED   1200981
REFERENCE   10 (bases 1 to 4678)
  AUTHORS   Potter,M., Pumphrey,J.G. and Bailey,D.W.
  TITLE     Genetics of susceptibility to plasmacytoma induction. I. BALB/cAnN
            (C), C57BL/6N (B6), C57BL/Ka (BK), (C times B6)F1, (C times BK)F1,
            and C times B recombinant-inbred strains
  JOURNAL   J Natl Cancer Inst 54 (6), 1413-1417 (1975)
   PUBMED   1133851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB843483.1, BY149778.1, AK045199.1 and AW109770.1.
            
            On or before Mar 21, 2014 this sequence version replaced
            XM_006538460.1, XM_006537060.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream start codon, compared to variant 1. It encodes isoform
            2, which has a shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172249.1, AK159373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BB843483.1         2-60
            60-205              BY149778.1         1-146
            206-4671            AK045199.1         275-4740
            4672-4678           AW109770.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..4678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 80.65 cM"
     gene            1..4678
                     /gene="H6pd"
                     /gene_synonym="G6pd1; Gpd-1; Gpd1"
                     /note="hexose-6-phosphate dehydrogenase (glucose
                     1-dehydrogenase)"
                     /db_xref="GeneID:100198"
                     /db_xref="MGI:MGI:2140356"
     exon            1..205
                     /gene="H6pd"
                     /gene_synonym="G6pd1; Gpd-1; Gpd1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..842
                     /gene="H6pd"
                     /gene_synonym="G6pd1; Gpd-1; Gpd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..2594
                     /gene="H6pd"
                     /gene_synonym="G6pd1; Gpd-1; Gpd1"
                     /EC_number="1.1.1.47"
                     /EC_number="3.1.1.31"
                     /EC_number="1.1.1.363"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; GDH/6PGL endoplasmic bifunctional protein;
                     glucose 1-dehydrogenase; glucose-6-phosphate dehydrogenase
                     1"
                     /codon_start=1
                     /product="GDH/6PGL endoplasmic bifunctional protein
                     isoform 2 precursor"
                     /protein_id="NP_001277933.1"
                     /db_xref="CCDS:CCDS71524.1"
                     /db_xref="GeneID:100198"
                     /db_xref="MGI:MGI:2140356"
                     /translation="MLLAAMCLALLGCLQAQELKGHVSIILLGATGDLAKKYLWQGLF
                     QLYLDEAGKGHSFSFHGAALTAPQQGQKLMDKVLESLSCPKDLVPSRCDELKGQFLQL
                     SQYRQLKTVEDYQTLNKDIETQVQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPH
                     PGAWLRVVFEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQN
                     RKALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVIRDTLQNHLTEILTLVAMEL
                     PLNISSSAAVLQHKLWAFQALRGLQKSSAILGQYQAYSGQVRRELQKPDGFQSLTPTF
                     AGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNRAYCTQSERHWVPEQSRCLP
                     QQIIFYIGHGELGHPAILVSRNLFKPSLPTQKWKEVQDQPGLRLFGRPLSDYYAYRPV
                     REQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLAFEVPRPYPGGAENGQL
                     LDFEFSGGQLTFSQQQLEVLIPDLGSVPKPSDFQVLGARYRQSPLITAWPEELISKLA
                     SDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGHYSFPWAHTHLWLVDERCVPL
                     SDPDSNFQGLQAHLLQHVRVPYYNIHPMPVHLHQRLCAEEDQGAQTYASEISALVANS
                     SFDLVLLGMGTDGHTASLFPQSPTGLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKV
                     AVLVMGRTKREITTLVSRVGHEPKKWPISGVVPLSGQLVWYMDYEAFLG"
     exon            843..960
                     /gene="H6pd"
                     /gene_synonym="G6pd1; Gpd-1; Gpd1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1230
                     /gene="H6pd"
                     /gene_synonym="G6pd1; Gpd-1; Gpd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..4678
                     /gene="H6pd"
                     /gene_synonym="G6pd1; Gpd-1; Gpd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4379..4384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H6pd"
                     /gene_synonym="G6pd1; Gpd-1; Gpd1"
                     /note="hexamer: AATAAA"
     polyA_site      4401
                     /gene="H6pd"
                     /gene_synonym="G6pd1; Gpd-1; Gpd1"
     regulatory      4647..4652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H6pd"
                     /gene_synonym="G6pd1; Gpd-1; Gpd1"
                     /note="hexamer: ATTAAA"
     polyA_site      4672
                     /gene="H6pd"
                     /gene_synonym="G6pd1; Gpd-1; Gpd1"
                     /note="major polyA site"
ORIGIN      
        1 ttgcaatcaa aacattgcaa aaaggttcaa aggggctttg agtgctcctc cgggctccca
       61 gttatcttta gaggaggccg gagaaagggc tctttggact tagaggagag cttcatctgg
      121 aagtgctggt ccccagattg gccatgaggg gaccaaatgc agaccagggt tgactgacac
      181 caggttgtgt tctttgcctg cactggcaca caggcatttg gaagatgctc ctagcggcaa
      241 tgtgcttggc ccttctgggc tgcctacagg cgcaggaact caagggtcat gtttccataa
      301 tcctgctggg agcaaccggg gacctagcta aaaagtacct gtggcaggga ctgtttcagc
      361 tatacctgga tgaggctggg aagggccaca gtttcagctt ccacggtgct gccctgacag
      421 ccccccagca aggccagaag ctcatggaca aggtcttgga atccctctcc tgtcccaagg
      481 acttggtacc cagtcgctgt gatgaactca agggtcagtt tctacagctg agccaatacc
      541 gccagctgaa gacagtggag gactatcaga ccctcaacaa ggatattgag acccaggtcc
      601 agcaggatgg gctctgggag gcaggcagga tcttctactt cagtgtgccg ccctttgcct
      661 acgcagacat tgcccgtaac atcaacagca gctgccgacc acacccaggt gcctggctac
      721 gggttgtttt tgaaaaaccc tttggccatg accacctctc agcccagcag ctggcttcag
      781 aacttgggag ctttttccag gaggaggaga tgtaccgtgt ggatcattac ctcggcaagc
      841 aggcggtggc tcagatcctg cccttccgag atcagaaccg caaggccttg gatggcctct
      901 ggaacaggca ccatgtggag cgggtggaga tcatcttgaa ggagaccata gatgcggaag
      961 gtcgggccag tttctatgag gagtatggcg tcatccgtga cacgctgcag aaccacctga
     1021 ctgagatcct cacgctggtg gccatggaac tgcctctcaa catcagcagc tcagccgccg
     1081 tgctccagca taagctctgg gccttccagg ccctgcgggg gctgcagaag agcagtgcca
     1141 tcctgggcca gtaccaggcc tacagcggac aggtgcgccg agagctgcag aagccagacg
     1201 gcttccagag cctgacacca accttcgcag gtgtccttgt ccacatcgac aacctgcgct
     1261 gggagggtgt ccctttcatc ctgatgtctg gcaaggcctt ggatgagaga gtgggctatg
     1321 ttcggattgt gtttaagaat cgggcgtact gcacccagag cgagagacac tgggtgccgg
     1381 agcagagccg gtgcctgccc cagcagatta tcttctacat tggacacggt gagctgggcc
     1441 accctgccat tctggtcagc cggaacctgt tcaaaccctc actacccact cagaagtgga
     1501 aggaggtgca ggaccagcct gggctccgcc tgttcggccg tcctctgtct gattactacg
     1561 cctacaggcc tgtgcgggag caagacgcct actccaccct cctgtcgcac atcttccact
     1621 gccgaaagga gtccttcatc accacagaga acctcttggc ctcctgggtc ttctggaccc
     1681 cgttactgga cagcctggcc tttgaagttc cacgcccata cccaggggga gccgagaatg
     1741 gccagctgct ggactttgag tttagcggtg gtcagctgac cttctcccag cagcagctgg
     1801 aggtgctgat accagatcta ggctcagtcc caaagcccag tgacttccag gtcctcgggg
     1861 cccggtatag acagagccca ctgattaccg cctggccaga ggagctgatc tctaagctgg
     1921 ccagtgacat tgaagccgcc gcggtgcagg cagtacggca cttcggcaag ttccacctgg
     1981 cactgtcagg tggttcgagc cccatagctc tcttccagca gctggccaca ggacattaca
     2041 gcttcccctg ggcccacaca cacctctggc tggttgatga gcgttgtgtc cctctctcag
     2101 atccagactc caacttccag ggcctgcagg ctcacctgct acagcacgtc agggtaccct
     2161 actacaacat ccacccgatg ccagtgcacc tgcaccagcg gctctgtgcc gaggaggacc
     2221 agggagctca gacctatgcc agtgagatct cagccctggt ggccaacagc agcttcgacc
     2281 tggtgctcct gggcatgggc accgacgggc acacagcttc tctgttccca cagtccccca
     2341 caggcctgga tggtgatcag ctggtggtgc tgacggagag cccgttcagg ccacaccaac
     2401 gcatgagcct cagcctgccc ctcatcaacc gagccaagaa ggtagctgtc ctggtcatgg
     2461 gcaggacaaa acgtgagatc acaacgttgg tgagccgcgt gggccatgaa cccaagaagt
     2521 ggcccatctc aggtgtggtg cctctttctg ggcagctggt ttggtacatg gattacgagg
     2581 cctttctggg atgacagtac catcctggtc ttagtcactc tcagccttcc tctttagctg
     2641 cccactgtgc ctcagctgtg tggagcctgg taccagagtc aggccccaga gaagggagga
     2701 caaaactctg tgccgacttc ctggacccac tggttctcgg gaatttcggt gcctgcacat
     2761 ggaaacaagg tagagctctg gcctcaaaac ccagatagga gagggactaa ggcctccagc
     2821 agttacacac cagtagctac aacacacagt aagactgggc gaaggctcca cgctaaagaa
     2881 ccaaagtggc ctgccaagac tggcctgcga tcttcaaact ggtttctgtg gaaagagggg
     2941 ccagtgttga tggggagcag ggtgcagaga ctcctggtga atgtcttgct ctgagccagg
     3001 ccagcagagt agacacaatc ctgagcctgc accgggcgcc ttgcctcttc tggtatccca
     3061 tcatccctct gtgcacctag ctgagatcca gcgctcctcc gggcagcttc tgtctactct
     3121 gggaggacac ccactgtcct cagtattccc cattacccct cagcctctcc ctctctacag
     3181 acacagacac tgccacgtca gaagttcccc cagatctaga gaccggggct ccctttccca
     3241 ctaagaactg ttatgctgtc attgggctgt cgggcatctc tgatctatct agacgggagg
     3301 gctctgtctg ctcctgggtc gggggtgact ccagatcaca gcctctttct agggcttatg
     3361 tggccaattg ccagcatcag ggcagactgc agctagccct cctcacacta cctctctctg
     3421 gcttcaagtc tggcagcagc ccctcctctg ccgggcatct ccaccattct tactgacgaa
     3481 cctggtacca ctgggaacac tacaggcagc tcctaacttc agtcccctcc agggccaaca
     3541 acataaacat ttcagggcac atacagtttt catttaggcc tcctgctgag tcatgtgaac
     3601 aagggaaggc ccagaagggt taggatggcc cgtcctcaca gttacctatg tgtcagtcac
     3661 agagtctccg tgtctttcag aattttccca tagagaggtt tcctgtgatg aggagcgtca
     3721 ggaaatctgt ttctctcctt ttatttgatt gtactttctc ccagacagca catggaaaag
     3781 aattcttgct ttcactagag atgtgtgcat agagtgtagc ctgagctgag ggctctgtat
     3841 gaaaggcact cttgttgaaa ttctgcttac tctgacctcc agtgacccag actgacagaa
     3901 cacctctatt ccttggcaga aaagaggaac gccctggggt cctttcctgg cctgctttgc
     3961 tcaggcttgg atgcaggtag tcgcaggtga agttccacct ttagccatgt gggggagccc
     4021 acgtgccacc actcacattc cacccaggag gcgggtttta gtgccaaacg tcttttcttc
     4081 gcttttcttg ctcactgcct ctcaggcgtc ttagcccagt gcgttttcat cagttcttag
     4141 ggactcggcc ttctgcagtt gcaacatcag agagcaaggg gccttgcatg cctcaggaga
     4201 gagggtgccc aggctctgtg tcaccattct gaataacggt gagtcactgc ccagcctgag
     4261 cctagaatgt cccgttctta tccagatgaa tgactcgcct ctgtctgtgg ggagtctctg
     4321 cacaggggag gccagtgtgg gggaaatacc aaagatctcc tttccggaag caagcacaaa
     4381 taaaatttca ttggaaaggt tggtggggga cattgtctgt gttctctggc atgcacctgt
     4441 gtgtgccctt tccctttctg ccccgggtta ggaaggagtg atgttcagag ccaggaccac
     4501 ggaagatgct gctcttcaga ctttctgaac catcatccac agccagcagg gctttaccaa
     4561 tcagtcacat ctgtgtacga atctgtctca ggaaggagct ctcagcctta agacctggga
     4621 taccctctat ttttttaaaa attttcatta aaaaattgtt gcttgcaaac cacttaac
//
