LOCUS       NM_178193                450 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H4 clustered histone 2 (H4c2), mRNA.
ACCESSION   NM_178193 NM_153146
VERSION     NM_178193.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Liu,L.J., Xie,R., Hussain,S., Lian,J.B., Rivera-Perez,J.,
            Jones,S.N., Stein,J.L., Stein,G.S. and van Wijnen,A.J.
  TITLE     Functional coupling of transcription factor HiNF-P and histone H4
            gene expression during pre- and post-natal mouse development
  JOURNAL   Gene 483 (1-2), 1-10 (2011)
   PUBMED   21605641
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   3  (bases 1 to 450)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
REFERENCE   4  (bases 1 to 450)
  AUTHORS   Meier,V.S., Bohni,R. and Schumperli,D.
  TITLE     Nucleotide sequence of two mouse histone H4 genes
  JOURNAL   Nucleic Acids Res 17 (2), 795 (1989)
   PUBMED   2915930
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590388.4.
            
            On Feb 22, 2014 this sequence version replaced NM_178193.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H4
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC132212.1, BE847667.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               AL590388.4         130992-131441       c
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.91 cM"
     gene            1..450
                     /gene="H4c2"
                     /gene_synonym="H4c1; H4c11; H4c12; H4c14; H4c16; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4b"
                     /note="H4 clustered histone 2"
                     /db_xref="GeneID:326620"
                     /db_xref="MGI:MGI:2448420"
     exon            1..450
                     /gene="H4c2"
                     /gene_synonym="H4c1; H4c11; H4c12; H4c14; H4c16; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..396
                     /gene="H4c2"
                     /gene_synonym="H4c1; H4c11; H4c12; H4c14; H4c16; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4b"
                     /note="histone 1, H4b; histone cluster 1, H4b"
                     /codon_start=1
                     /product="histone H4"
                     /protein_id="NP_835500.1"
                     /db_xref="CCDS:CCDS26366.1"
                     /db_xref="GeneID:326620"
                     /db_xref="MGI:MGI:2448420"
                     /translation="MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV
                     KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
                     G"
     regulatory      400..405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H4c2"
                     /gene_synonym="H4c1; H4c11; H4c12; H4c14; H4c16; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4b"
                     /note="hexamer: ACTAAA"
     polyA_site      450
                     /gene="H4c2"
                     /gene_synonym="H4c1; H4c11; H4c12; H4c14; H4c16; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4b"
                     /note="major polyA site"
ORIGIN      
        1 caaccaggtc cgataagagc ctataataac acagcgaatt cttagttcac cagcttccta
       61 ctgaaagctt gtaagaattt aactatgtct ggtcgcggca agggaggaaa aggcctgggc
      121 aaaggtggcg ctaagcgcca tcgcaaagtg ctgcgcgaca acatccaggg catcaccaag
      181 cccgccatcc gccgcctggc ccggcgcggg ggagtgaagc gcatctccgg cctcatctac
      241 gaggagaccc gcggtgtgct gaaggtgttc ctggagaacg tgatccgcga cgccgtcacc
      301 tacacggagc acgccaagcg caagaccgtc accgccatgg acgtggtcta cgcgctcaag
      361 cgccagggcc gcaccctcta cggattcggg ggttaaggga ctaaagcgat tttcttaact
      421 gttacaaaag gtccttttca ggaccactca
//
