LOCUS       NM_175657                406 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H4 clustered histone 18 (H4c18), mRNA.
ACCESSION   NM_175657
VERSION     NM_175657.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 406)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL589879.21.
            
            On Jun 19, 2019 this sequence version replaced NM_175657.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H4
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. [provided by RefSeq, Sep
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AV472770.1, CJ090441.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               AL589879.21        31959-32364         c
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 8.0 cM"
     gene            1..406
                     /gene="H4c18"
                     /gene_synonym="H4c1; H4c11; H4c12; H4c14; H4c16; H4c2;
                     H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4n"
                     /note="H4 clustered histone 18"
                     /db_xref="GeneID:319161"
                     /db_xref="MGI:MGI:4843992"
     exon            1..406
                     /gene="H4c18"
                     /gene_synonym="H4c1; H4c11; H4c12; H4c14; H4c16; H4c2;
                     H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4n"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..351
                     /gene="H4c18"
                     /gene_synonym="H4c1; H4c11; H4c12; H4c14; H4c16; H4c2;
                     H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4n"
                     /note="histone cluster 1, H4n"
                     /codon_start=1
                     /product="histone H4"
                     /protein_id="NP_783588.1"
                     /db_xref="CCDS:CCDS26300.1"
                     /db_xref="GeneID:319161"
                     /db_xref="MGI:MGI:4843992"
                     /translation="MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV
                     KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
                     G"
     regulatory      379..384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H4c18"
                     /gene_synonym="H4c1; H4c11; H4c12; H4c14; H4c16; H4c2;
                     H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4n"
                     /note="hexamer: ACTAAA"
     polyA_site      406
                     /gene="H4c18"
                     /gene_synonym="H4c1; H4c11; H4c12; H4c14; H4c16; H4c2;
                     H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4n"
                     /note="major polyA site"
ORIGIN      
        1 gtctgcttcg tcttagagca gtacagtttt gtcttcatca tgtctggtcg tggcaaagga
       61 ggaaaaggcc tgggcaaagg cggcgccaag cgccaccgca aagtgctgcg cgataacatc
      121 cagggcatca cgaagcccgc catccgccgc ctggcccggc gcggaggagt gaagcgcatc
      181 tccggcctca tctacgagga gacccgcggt gtgctgaagg tgttcctgga gaacgtgatc
      241 cgcgacgccg tcacctacac ggagcacgcc aagcgcaaga ctgtcaccgc catggacgtg
      301 gtctacgcgc tcaagcgcca gggccgcacc ctctacggat tcggcggcta attatgctca
      361 cctagagctt ctttctcaac taaaggccct tttcagggcc atccaa
//
