LOCUS       NM_001195421             405 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H4 clustered histone 17 (H4c17), mRNA.
ACCESSION   NM_001195421 XM_001476063
VERSION     NM_001195421.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 405)
  AUTHORS   Liu,L.J., Xie,R., Hussain,S., Lian,J.B., Rivera-Perez,J.,
            Jones,S.N., Stein,J.L., Stein,G.S. and van Wijnen,A.J.
  TITLE     Functional coupling of transcription factor HiNF-P and histone H4
            gene expression during pre- and post-natal mouse development
  JOURNAL   Gene 483 (1-2), 1-10 (2011)
   PUBMED   21605641
REFERENCE   2  (bases 1 to 405)
  AUTHORS   Caron,C., Lestrat,C., Marsal,S., Escoffier,E., Curtet,S.,
            Virolle,V., Barbry,P., Debernardi,A., Brambilla,C., Brambilla,E.,
            Rousseaux,S. and Khochbin,S.
  TITLE     Functional characterization of ATAD2 as a new cancer/testis factor
            and a predictor of poor prognosis in breast and lung cancers
  JOURNAL   Oncogene 29 (37), 5171-5181 (2010)
   PUBMED   20581866
REFERENCE   3  (bases 1 to 405)
  AUTHORS   Toleman,C.A., Paterson,A.J. and Kudlow,J.E.
  TITLE     The histone acetyltransferase NCOAT contains a zinc finger-like
            motif involved in substrate recognition
  JOURNAL   J Biol Chem 281 (7), 3918-3925 (2006)
   PUBMED   16356930
REFERENCE   4  (bases 1 to 405)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL589879.21.
            
            On Sep 10, 2010 this sequence version replaced XM_001476063.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H4
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC115449.1, SRR5189676.148553.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               AL589879.21        11913-12317
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.99 cM"
     gene            1..405
                     /gene="H4c17"
                     /gene_synonym="Gm11275; H4c1; H4c11; H4c12; H4c14; H4c16;
                     H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4m"
                     /note="H4 clustered histone 17"
                     /db_xref="GeneID:100041230"
                     /db_xref="MGI:MGI:2448441"
     exon            1..405
                     /gene="H4c17"
                     /gene_synonym="Gm11275; H4c1; H4c11; H4c12; H4c14; H4c16;
                     H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4m"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..350
                     /gene="H4c17"
                     /gene_synonym="Gm11275; H4c1; H4c11; H4c12; H4c14; H4c16;
                     H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4m"
                     /note="histone cluster 1, H4m"
                     /codon_start=1
                     /product="histone H4"
                     /protein_id="NP_001182350.1"
                     /db_xref="CCDS:CCDS56872.1"
                     /db_xref="GeneID:100041230"
                     /db_xref="MGI:MGI:2448441"
                     /translation="MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV
                     KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
                     G"
     regulatory      378..383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H4c17"
                     /gene_synonym="Gm11275; H4c1; H4c11; H4c12; H4c14; H4c16;
                     H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4m"
                     /note="hexamer: ACTAAA"
     polyA_site      405
                     /gene="H4c17"
                     /gene_synonym="Gm11275; H4c1; H4c11; H4c12; H4c14; H4c16;
                     H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4m"
                     /note="major polyA site"
ORIGIN      
        1 tctgcttcgt cttagagcag tacagttttg tcttcgtcat gtctggtcgt ggcaaaggag
       61 gaaaaggcct gggcaaaggc ggcgccaagc gccaccgcaa agtgctgcgc gataacatcc
      121 agggcatcac gaagcccgcc atccgccgcc tggcccggcg cggaggagtg aagcgcatct
      181 ccggcctcat ctacgaggag acccgcggtg tgctgaaggt gttcctggag aacgtgatcc
      241 gcgacgccgt cacctacacg gagcacgcca agcgcaagac tgtcaccgcc atggacgtgg
      301 tctacgcgct caagcgccag ggccgcaccc tctacggatt cggcggctaa ttatgctcac
      361 ctagagcttc tttctcaact aaaggccctt ttcagggcca tccaa
//
