LOCUS       NM_178211                409 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H4 clustered histone 12 (H4c12), mRNA.
ACCESSION   NM_178211
VERSION     NM_178211.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 409)
  AUTHORS   Liu,L.J., Xie,R., Hussain,S., Lian,J.B., Rivera-Perez,J.,
            Jones,S.N., Stein,J.L., Stein,G.S. and van Wijnen,A.J.
  TITLE     Functional coupling of transcription factor HiNF-P and histone H4
            gene expression during pre- and post-natal mouse development
  JOURNAL   Gene 483 (1-2), 1-10 (2011)
   PUBMED   21605641
REFERENCE   2  (bases 1 to 409)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL589651.8.
            
            On Mar 1, 2014 this sequence version replaced NM_178211.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H4
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC117010.1, BY725349.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               AL589651.8         171135-171543       c
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.95 cM"
     gene            1..409
                     /gene="H4c12"
                     /gene_synonym="H4c1; H4c11; H4c14; H4c16; H4c2; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4k"
                     /note="H4 clustered histone 12"
                     /db_xref="GeneID:319160"
                     /db_xref="MGI:MGI:2448439"
     exon            1..409
                     /gene="H4c12"
                     /gene_synonym="H4c1; H4c11; H4c14; H4c16; H4c2; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4k"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..360
                     /gene="H4c12"
                     /gene_synonym="H4c1; H4c11; H4c14; H4c16; H4c2; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4k"
                     /note="histone 1, H4k; histone cluster 1, H4k"
                     /codon_start=1
                     /product="histone H4"
                     /protein_id="NP_835583.1"
                     /db_xref="CCDS:CCDS26292.1"
                     /db_xref="GeneID:319160"
                     /db_xref="MGI:MGI:2448439"
                     /translation="MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV
                     KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
                     G"
     polyA_site      409
                     /gene="H4c12"
                     /gene_synonym="H4c1; H4c11; H4c14; H4c16; H4c2; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4k"
                     /note="major polyA site"
ORIGIN      
        1 tcaggctccc tgtcagcatc tctgttctga gctgtcctga gtgcagtcat gtctggcaga
       61 ggtaagggcg ggaaagggct cggtaaaggt ggcgccaagc gccaccgcaa agtgctgcgc
      121 gataacatcc agggcatcac caagcccgcc atccgccgcc tggcccggcg cgggggagtg
      181 aagcgcatct ccggcctcat ctacgaggag acccgcggtg tgctgaaggt gttcctggag
      241 aacgtgatcc gcgacgccgt cacctacacg gagcacgcca agcgcaagac cgtcaccgcc
      301 atggacgtgg tctacgcgct caagcgccag ggccgcaccc tctacggatt cggaggctaa
      361 gtctttgtct tttatttctg ctacaaaagg cccttttcag ggccaccca
//
