LOCUS       NM_178192                455 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus H4 clustered histone 1 (H4c1), mRNA.
ACCESSION   NM_178192
VERSION     NM_178192.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Yang,P., Xu,C., Reece,E.A., Chen,X., Zhong,J., Zhan,M.,
            Stumpo,D.J., Blackshear,P.J. and Yang,P.
  TITLE     Tip60- and sirtuin 2-regulated MARCKS acetylation and
            phosphorylation are required for diabetic embryopathy
  JOURNAL   Nat Commun 10 (1), 282 (2019)
   PUBMED   30655546
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Dey,A., Seshasayee,D., Noubade,R., French,D.M., Liu,J.,
            Chaurushiya,M.S., Kirkpatrick,D.S., Pham,V.C., Lill,J.R.,
            Bakalarski,C.E., Wu,J., Phu,L., Katavolos,P., LaFave,L.M.,
            Abdel-Wahab,O., Modrusan,Z., Seshagiri,S., Dong,K., Lin,Z.,
            Balazs,M., Suriben,R., Newton,K., Hymowitz,S., Garcia-Manero,G.,
            Martin,F., Levine,R.L. and Dixit,V.M.
  TITLE     Loss of the tumor suppressor BAP1 causes myeloid transformation
  JOURNAL   Science 337 (6101), 1541-1546 (2012)
   PUBMED   22878500
REFERENCE   3  (bases 1 to 455)
  AUTHORS   Liu,L.J., Xie,R., Hussain,S., Lian,J.B., Rivera-Perez,J.,
            Jones,S.N., Stein,J.L., Stein,G.S. and van Wijnen,A.J.
  TITLE     Functional coupling of transcription factor HiNF-P and histone H4
            gene expression during pre- and post-natal mouse development
  JOURNAL   Gene 483 (1-2), 1-10 (2011)
   PUBMED   21605641
REFERENCE   4  (bases 1 to 455)
  AUTHORS   Tou,L., Liu,Q. and Shivdasani,R.A.
  TITLE     Regulation of mammalian epithelial differentiation and intestine
            development by class I histone deacetylases
  JOURNAL   Mol Cell Biol 24 (8), 3132-3139 (2004)
   PUBMED   15060137
REFERENCE   5  (bases 1 to 455)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 455)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 455)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590388.4.
            
            On Feb 22, 2014 this sequence version replaced NM_178192.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H4
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC119241.1, BY715949.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-455               AL590388.4         127129-127583
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.91 cM"
     gene            1..455
                     /gene="H4c1"
                     /gene_synonym="H4c11; H4c12; H4c14; H4c16; H4c2; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4a"
                     /note="H4 clustered histone 1"
                     /db_xref="GeneID:326619"
                     /db_xref="MGI:MGI:2448419"
     exon            1..455
                     /gene="H4c1"
                     /gene_synonym="H4c11; H4c12; H4c14; H4c16; H4c2; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..404
                     /gene="H4c1"
                     /gene_synonym="H4c11; H4c12; H4c14; H4c16; H4c2; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4a"
                     /note="histone 1, H4a; histone cluster 1, H4a"
                     /codon_start=1
                     /product="histone H4"
                     /protein_id="NP_835499.1"
                     /db_xref="CCDS:CCDS26367.1"
                     /db_xref="GeneID:326619"
                     /db_xref="MGI:MGI:2448419"
                     /translation="MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV
                     KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG
                     G"
     polyA_site      455
                     /gene="H4c1"
                     /gene_synonym="H4c11; H4c12; H4c14; H4c16; H4c2; H4c3;
                     H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4a"
                     /note="major polyA site"
ORIGIN      
        1 tgtgattctg ttgggggtgg gagatcaagg ccaagcagct atataaagga ccgactctca
       61 gctctgactc cattttccat tcttcctaag acatgtcggg tcgcggcaag ggaggaaaag
      121 gcctgggcaa aggcggcgct aagcgccacc gtaaggttct ccgcgataac atccagggca
      181 tcaccaagcc cgccatccgc cgcctggccc ggcgcggggg agtgaagcgc atctccggcc
      241 tcatctacga ggagacccgc ggtgtgctga aggtgttcct ggagaacgtg atccgcgacg
      301 ccgtcaccta cacggagcac gccaagcgca agaccgtcac cgccatggac gtggtctacg
      361 cgctcaagcg ccagggccgc accctctacg gattcggcgg ctaagacttt tttaatttgt
      421 attttctaac caaaggccct tctcagggcc gccca
//
