LOCUS       NM_001318003             563 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus H3.4 histone, cluster member (H3f4), mRNA.
ACCESSION   NM_001318003
VERSION     NM_001318003.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 563)
  AUTHORS   Wu,Q., Ito,M., Fujii,T., Tanaka,K., Nakatani,K., Izumi,Y.,
            Bamba,T., Baba,T., Maehara,K., Tomimatsu,K., Takemoto,T., Ohkawa,Y.
            and Harada,A.
  TITLE     Defects in the H3t Gene Cause an Increase in Leydig Cells With
            Impaired Spermatogenesis in Mice
  JOURNAL   Genes Cells 30 (1), e13182 (2025)
   PUBMED   39624989
REFERENCE   2  (bases 1 to 563)
  AUTHORS   Kawaguchi,T., Hashimoto,M., Nakagawa,R., Minami,R., Ikawa,M.,
            Nakayama,J.I. and Ueda,J.
  TITLE     Comprehensive posttranslational modifications in the
            testis-specific histone variant H3t protein validated in tagged
            knock-in mice
  JOURNAL   Sci Rep 14 (1), 21305 (2024)
   PUBMED   39266663
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 563)
  AUTHORS   Chan,J.C., Alenina,N., Cunningham,A.M., Ramakrishnan,A., Shen,L.,
            Bader,M. and Maze,I.
  TITLE     Serotonin Transporter-dependent Histone Serotonylation in Placenta
            Contributes to the Neurodevelopmental Transcriptome
  JOURNAL   J Mol Biol 436 (7), 168454 (2024)
   PUBMED   38266980
REFERENCE   4  (bases 1 to 563)
  AUTHORS   Ueda,J., Harada,A., Urahama,T., Machida,S., Maehara,K., Hada,M.,
            Makino,Y., Nogami,J., Horikoshi,N., Osakabe,A., Taguchi,H.,
            Tanaka,H., Tachiwana,H., Yao,T., Yamada,M., Iwamoto,T., Isotani,A.,
            Ikawa,M., Tachibana,T., Okada,Y., Kimura,H., Ohkawa,Y.,
            Kurumizaka,H. and Yamagata,K.
  TITLE     Testis-Specific Histone Variant H3t Gene Is Essential for Entry
            into Spermatogenesis
  JOURNAL   Cell Rep 18 (3), 593-600 (2017)
   PUBMED   28099840
REFERENCE   5  (bases 1 to 563)
  AUTHORS   Maehara,K., Harada,A., Sato,Y., Matsumoto,M., Nakayama,K.I.,
            Kimura,H. and Ohkawa,Y.
  TITLE     Tissue-specific expression of histone H3 variants diversified after
            species separation
  JOURNAL   Epigenetics Chromatin 8, 35 (2015)
   PUBMED   26388943
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 563)
  AUTHORS   Govin,J., Escoffier,E., Rousseaux,S., Kuhn,L., Ferro,M.,
            Thevenon,J., Catena,R., Davidson,I., Garin,J., Khochbin,S. and
            Caron,C.
  TITLE     Pericentric heterochromatin reprogramming by new histone variants
            during mouse spermiogenesis
  JOURNAL   J Cell Biol 176 (3), 283-294 (2007)
   PUBMED   17261847
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662809.14.
            
            On Dec 19, 2015 this sequence version replaced NM_001318003.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H3
            family. [provided by RefSeq, Dec 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BU937304.1, SRR1660819.91206.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 26388943
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-563               AL662809.14        46183-46745
FEATURES             Location/Qualifiers
     source          1..563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 36.39 cM"
     gene            1..563
                     /gene="H3f4"
                     /gene_synonym="Gm12260; H304; H3mmT; H3t"
                     /note="H3.4 histone, cluster member"
                     /db_xref="GeneID:382523"
                     /db_xref="MGI:MGI:3651326"
     exon            1..563
                     /gene="H3f4"
                     /gene_synonym="Gm12260; H304; H3mmT; H3t"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..512
                     /gene="H3f4"
                     /gene_synonym="Gm12260; H304; H3mmT; H3t"
                     /note="histone cluster 1, H3 pseudogene; H3.4 histone"
                     /codon_start=1
                     /product="uncharacterized protein LOC382523"
                     /protein_id="NP_001304932.1"
                     /db_xref="GeneID:382523"
                     /db_xref="MGI:MGI:3651326"
                     /translation="MARTKQTARKSTGGKAPRKQLATKVARKSAPATGGVKKPHRYHP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACESYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
ORIGIN      
        1 ggtgggcagc caataggaat gtagctgggt ctataaaagc agtgctactc gccccccaca
       61 ttgtgcacct gaggagcaag ggaggcggac gattcaggaa gatggcacgc accaagcaga
      121 cggcacggaa gtcgacggga ggcaaggctc cgcgcaagca gctagccacg aaggtggccc
      181 gcaagagcgc cccggccacc gggggcgtga agaagccgca ccgctaccac cctggcacgg
      241 tggcgctgcg cgagatccgg cgctaccaga agtccaccga gctgctgatt cgcaagttgc
      301 cattccagcg cttggtgcgt gagatcgccc aggacttcaa gaccgacctg cgcttccaga
      361 gctccgcggt gatggcgctg caggaggcct gcgagtcgta cctcgtgggg ctgttcgaag
      421 acacgaacct gtgcgctatc cacgccaagc gggtgaccat catgcccaaa gacatccagt
      481 tggctcggcg catccgcgga gaacgggctt aggctcccac aggcaccgct catgaaccca
      541 acggctcttt tcagagccac cca
//
