LOCUS       NM_008211               1993 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus H3.3 histone B (H3f3b), mRNA.
ACCESSION   NM_008211 XM_902379 XM_921651
VERSION     NM_008211.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1993)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1993)
  AUTHORS   Zhang,X., Che,Y., Mao,L., Li,D., Deng,J., Guo,Y., Zhao,Q.,
            Zhang,X., Wang,L., Gao,X., Chen,Y. and Zhang,T.
  TITLE     H3.3B controls aortic dissection progression by regulating vascular
            smooth muscle cells phenotypic transition and vascular inflammation
  JOURNAL   Genomics 115 (5), 110685 (2023)
   PUBMED   37454936
  REMARK    GeneRIF: H3.3B controls aortic dissection progression by regulating
            vascular smooth muscle cells phenotypic transition and vascular
            inflammation.
REFERENCE   3  (bases 1 to 1993)
  AUTHORS   Bush,K., Cervantes,V., Yee,J.Q., Klein,R.H. and Knoepfler,P.S.
  TITLE     A knockout-first model of H3f3a gene targeting leads to
            developmental lethality
  JOURNAL   Genesis 61 (1-2), e23507 (2023)
   PUBMED   36656301
  REMARK    GeneRIF: A knockout-first model of H3f3a gene targeting leads to
            developmental lethality.
REFERENCE   4  (bases 1 to 1993)
  AUTHORS   Cohen,L.R.Z., Kaffe,B., Deri,E., Leibson,C., Nissim-Rafinia,M.,
            Maman,M., Harpaz,N., Ron,G., Shema,E. and Meshorer,E.
  TITLE     PRC2-independent actions of H3.3K27M in embryonic stem cell
            differentiation
  JOURNAL   Nucleic Acids Res 51 (4), 1662-1673 (2023)
   PUBMED   36156096
  REMARK    GeneRIF: PRC2-independent actions of H3.3K27M in embryonic stem
            cell differentiation.
            Erratum:[Nucleic Acids Res. 2023 Feb 28;51(4):1996. doi:
            10.1093/nar/gkad018.. PMID: 36625287]
REFERENCE   5  (bases 1 to 1993)
  AUTHORS   Funk,O.H., Qalieh,Y., Doyle,D.Z., Lam,M.M. and Kwan,K.Y.
  TITLE     Postmitotic accumulation of histone variant H3.3 in new cortical
            neurons establishes neuronal chromatin, transcriptome, and identity
  JOURNAL   Proc Natl Acad Sci U S A 119 (32), e2116956119 (2022)
   PUBMED   35930666
REFERENCE   6  (bases 1 to 1993)
  AUTHORS   Tang,M.C., Jacobs,S.A., Mattiske,D.M., Soh,Y.M., Graham,A.N.,
            Tran,A., Lim,S.L., Hudson,D.F., Kalitsis,P., O'Bryan,M.K.,
            Wong,L.H. and Mann,J.R.
  TITLE     Contribution of the two genes encoding histone variant h3.3 to
            viability and fertility in mice
  JOURNAL   PLoS Genet 11 (2), e1004964 (2015)
   PUBMED   25675407
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1993)
  AUTHORS   Albig,W., Bramlage,B., Gruber,K., Klobeck,H.G., Kunz,J. and
            Doenecke,D.
  TITLE     The human replacement histone H3.3B gene (H3F3B)
  JOURNAL   Genomics 30 (2), 264-272 (1995)
   PUBMED   8586426
REFERENCE   8  (bases 1 to 1993)
  AUTHORS   Kawabe,T., Naka,T., Yoshida,K., Tanaka,T., Fujiwara,H.,
            Suematsu,S., Yoshida,N., Kishimoto,T. and Kikutani,H.
  TITLE     The immune responses in CD40-deficient mice: impaired
            immunoglobulin class switching and germinal center formation
  JOURNAL   Immunity 1 (3), 167-178 (1994)
   PUBMED   7534202
REFERENCE   9  (bases 1 to 1993)
  AUTHORS   Krimer,D.B., Cheng,G. and Skoultchi,A.I.
  TITLE     Induction of H3.3 replacement histone mRNAs during the
            precommitment period of murine erythroleukemia cell differentiation
  JOURNAL   Nucleic Acids Res 21 (12), 2873-2879 (1993)
   PUBMED   8332496
REFERENCE   10 (bases 1 to 1993)
  AUTHORS   Hraba-Renevey,S. and Kress,M.
  TITLE     Expression of a mouse replacement histone H3.3 gene with a highly
            conserved 3' noncoding region during SV40- and polyoma-induced Go
            to S-phase transition
  JOURNAL   Nucleic Acids Res 17 (7), 2449-2461 (1989)
   PUBMED   2470025
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK153530.1, AK161675.1,
            AK151336.1, BY685958.1 and AV112938.1.
            
            On Oct 13, 2006 this sequence version replaced NM_008211.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene contains introns and its mRNA is
            polyadenylated, unlike most histone genes. The protein encoded by
            this gene is a replication-independent histone that is a member of
            the histone H3 family. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151222.1, AK011431.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            replication-independent histone :: PMID: 25675407
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK153530.1         1-3
            4-987               AK161675.1         2-985
            988-1661            AK151336.1         984-1657
            1662-1974           BY685958.1         62-374
            1975-1993           AV112938.1         192-210
FEATURES             Location/Qualifiers
     source          1..1993
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     gene            1..1993
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /note="H3.3 histone B"
                     /db_xref="GeneID:15081"
                     /db_xref="MGI:MGI:1101768"
     exon            1..126
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /inference="alignment:Splign:2.1.0"
     exon            127..264
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..547
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /note="H3L-like histone; H3 histone, family 3B"
                     /codon_start=1
                     /product="histone H3.3"
                     /protein_id="NP_032237.1"
                     /db_xref="CCDS:CCDS36377.1"
                     /db_xref="GeneID:15081"
                     /db_xref="MGI:MGI:1101768"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
     exon            265..418
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /inference="alignment:Splign:2.1.0"
     exon            419..1993
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      575..580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /note="hexamer: AGTAAA"
     polyA_site      592
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /note="major polyA site"
     regulatory      1633..1638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /note="hexamer: ACTAAA"
     regulatory      1645..1650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /note="hexamer: AATAAA"
     polyA_site      1660
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
     polyA_site      1667
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /note="major polyA site"
     regulatory      1950..1955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
                     /note="hexamer: AATAAA"
     polyA_site      1987
                     /gene="H3f3b"
                     /gene_synonym="9430068D06Rik; H3-3a; H3-3b; H3.3B"
ORIGIN      
        1 ggagcgcaga gcggtttggt cgttcgttgg tggagtatct gcccgttctg ctcgccgatt
       61 gcggctcttg ttcgagcgct tccagcgtcg cctcggtctc agcaagggcc ccagactcgg
      121 ctttgggtga aaaaaaatgg cccgaaccaa gcagaccgct aggaagtcca ccggtgggaa
      181 agccccccgc aaacagctgg ccaccaaggc ggctcggaaa agcgcgccct ctaccggcgg
      241 ggtgaagaag cctcaccgct acaggccagg gaccgtggct ctgagagaga tccgtcgtta
      301 ccagaaatcg actgagctgc tcatccggaa gctgccattc cagagattgg tgagggagat
      361 cgcccaggat ttcaaaaccg acttgaggtt tcaaagtgca gccatcggtg cccttcagga
      421 ggctagcgaa gcatacctgg tggggttgtt tgaagatacc aatctgtgtg ccatccacgc
      481 caagagagtc accatcatgc ccaaagacat ccagttggct cgccggatac ggggggagag
      541 agcttaagtt gaagcggttt ttatggcatt ttgtagtaaa ttctgtaaaa tactttggtt
      601 taatttgtga ctttttttgt aagaaattgt ttataatatg ttgcatttgt acttaagtca
      661 ttccatcttt cactcaggat gaatgggaag agtgactgac tgttcacaga cctcagtgat
      721 gtgagcactg tggctcagga gtgacaagtt gctaatacgc agaagggatg ggtgatactt
      781 cttgcttttc atgatgcatg tttctgtatg ttaatgactt gttgggtagc tattaaggta
      841 ctagaattga taaatgtgta cagggtcctt ttgcaataaa actggttatg acttgatcca
      901 agtgtttaac catacatcac tgtgatagaa tgtgggcttt ttcaaaggtt gaagatacaa
      961 gttttagcca cagtgtaaca gtttccttta aaaaaaaaaa agtaaacctg gcagctatag
     1021 aatacactat gtgcatttat aatagctatt ttatatattg tagtgttcaa catttttaaa
     1081 ttaaatgttt tacattcaca agtggtgggg agtcttgtca ttaaggtgtg tgtaatttag
     1141 tccagttggt atttcctgac tagactgcat ttgtttttaa cagtagaaaa atgctatgcg
     1201 tattaaacct tgcataagtc ctcattctac cacatgttca ctaacccctg accctctggc
     1261 tggtaacaca acactaacgg ggattttatt tataagggct ctagagtaaa ataacaagct
     1321 attcacacca gcatcatcta ttactaatct agttagtgca gcttttcatt gtgtttggtc
     1381 ttaggcctag attgagttcg gtttcgtttc tttttaatct ttaaggggga aaactgtaca
     1441 aggtttgttt ttccttgtag agtttataaa catgggagta agaacacagc ttcaacttct
     1501 tggacctctg ccaatgaaga tgggttaggt tacacctggt tactatactg gcaaaatccc
     1561 ttttatagag atggccttca agtggttttt aaaagtatcc tattgaagtt tttaggtcaa
     1621 ttatgtatgt tgactaaatt tacaaataaa cttgtttatt caactaagtg tcaaacctaa
     1681 attgaatata caaagctttt aatacatatg gaatcgagat tcctagattc agctatttgc
     1741 ttggtagaaa aggctaaagt acagaaagca tttgaacatc caatacactc taaaaatgca
     1801 agtatttgct gacacaattc atgagtctga caaaatctgc ttgtggttca tgggtgggct
     1861 taataactac aatacatgtt tgttcccatg gttttagaat atttgaaatt ttaagtttgc
     1921 tgttttggat ctttctaata ggccttacaa ataaactagt aagtttggag tttttttcct
     1981 ggggaaacag ttt
//
