LOCUS       NM_008210               1043 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus H3.3 histone A (H3f3a), mRNA.
ACCESSION   NM_008210 XM_359209
VERSION     NM_008210.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1043)
  AUTHORS   Khazaei,S., Chen,C.C.L., Andrade,A.F., Kabir,N., Azarafshar,P.,
            Morcos,S.M., Franca,J.A., Lopes,M., Lund,P.J., Danieau,G.,
            Worme,S., Adnani,L., Nzirorera,N., Chen,X., Yogarajah,G., Russo,C.,
            Zeinieh,M., Wong,C.J., Bryant,L., Hebert,S., Tong,B., Sihota,T.S.,
            Faury,D., Puligandla,E., Jawhar,W., Sandy,V., Cowan,M.,
            Nakada,E.M., Jerome-Majewska,L.A., Ellezam,B., Gomes,C.C.,
            Denecke,J., Lessel,D., McDonald,M.T., Pizoli,C.E., Taylor,K.,
            Cocanougher,B.T., Bhoj,E.J., Gingras,A.C., Garcia,B.A., Lu,C.,
            Campos,E.I., Kleinman,C.L., Garzia,L. and Jabado,N.
  TITLE     Single substitution in H3.3G34 alters DNMT3A recruitment to cause
            progressive neurodegeneration
  JOURNAL   Cell 186 (6), 1162-1178 (2023)
   PUBMED   36931244
REFERENCE   2  (bases 1 to 1043)
  AUTHORS   Bush,K., Cervantes,V., Yee,J.Q., Klein,R.H. and Knoepfler,P.S.
  TITLE     A knockout-first model of H3f3a gene targeting leads to
            developmental lethality
  JOURNAL   Genesis 61 (1-2), e23507 (2023)
   PUBMED   36656301
  REMARK    GeneRIF: A knockout-first model of H3f3a gene targeting leads to
            developmental lethality.
REFERENCE   3  (bases 1 to 1043)
  AUTHORS   Funk,O.H., Qalieh,Y., Doyle,D.Z., Lam,M.M. and Kwan,K.Y.
  TITLE     Postmitotic accumulation of histone variant H3.3 in new cortical
            neurons establishes neuronal chromatin, transcriptome, and identity
  JOURNAL   Proc Natl Acad Sci U S A 119 (32), e2116956119 (2022)
   PUBMED   35930666
REFERENCE   4  (bases 1 to 1043)
  AUTHORS   Udugama,M., Vinod,B., Chan,F.L., Hii,L., Garvie,A., Collas,P.,
            Kalitsis,P., Steer,D., Das,P.P., Tripathi,P., Mann,J.R.,
            Voon,H.P.J. and Wong,L.H.
  TITLE     Histone H3.3 phosphorylation promotes heterochromatin formation by
            inhibiting H3K9/K36 histone demethylase
  JOURNAL   Nucleic Acids Res 50 (8), 4500-4514 (2022)
   PUBMED   35451487
  REMARK    GeneRIF: Histone H3.3 phosphorylation promotes heterochromatin
            formation by inhibiting H3K9/K36 histone demethylase.
REFERENCE   5  (bases 1 to 1043)
  AUTHORS   Pinson,M.R., Chung,D.D., Mahnke,A.H., Salem,N.A., Osorio,D.,
            Nair,V., Payne,E.A., Del Real,J.J., Cai,J.J. and Miranda,R.C.
  TITLE     Gag-like proteins: Novel mediators of prenatal alcohol exposure in
            neural development
  JOURNAL   Alcohol Clin Exp Res 46 (4), 556-569 (2022)
   PUBMED   35187673
REFERENCE   6  (bases 1 to 1043)
  AUTHORS   Goto,H., Tomono,Y., Ajiro,K., Kosako,H., Fujita,M., Sakurai,M.,
            Okawa,K., Iwamatsu,A., Okigaki,T., Takahashi,T. and Inagaki,M.
  TITLE     Identification of a novel phosphorylation site on histone H3
            coupled with mitotic chromosome condensation
  JOURNAL   J Biol Chem 274 (36), 25543-25549 (1999)
   PUBMED   10464286
REFERENCE   7  (bases 1 to 1043)
  AUTHORS   Lopez-Fernandez,L.A., Lopez-Alanon,D.M., Castaneda,V., Krimer,D.B.
            and del Mazo,J.
  TITLE     Developmental expression of H3.3A variant histone mRNA in mouse
  JOURNAL   Int J Dev Biol 41 (5), 699-703 (1997)
   PUBMED   9415489
REFERENCE   8  (bases 1 to 1043)
  AUTHORS   Bramlage,B., Kosciessa,U. and Doenecke,D.
  TITLE     Differential expression of the murine histone genes H3.3A and H3.3B
  JOURNAL   Differentiation 62 (1), 13-20 (1997)
   PUBMED   9373943
REFERENCE   9  (bases 1 to 1043)
  AUTHORS   Lopez-Alanon,D.M., Lopez-Fernandez,L.A., Castaneda,V., Krimer,D.B.
            and Del Mazo,J.
  TITLE     H3.3A variant histone mRNA containing an alpha-globin insertion:
            modulated expression during mouse gametogenesis correlates with
            meiotic onset
  JOURNAL   DNA Cell Biol 16 (5), 639-644 (1997)
   PUBMED   9174168
REFERENCE   10 (bases 1 to 1043)
  AUTHORS   Hraba-Renevey,S. and Kress,M.
  TITLE     Expression of a mouse replacement histone H3.3 gene with a highly
            conserved 3' noncoding region during SV40- and polyoma-induced Go
            to S-phase transition
  JOURNAL   Nucleic Acids Res 17 (7), 2449-2461 (1989)
   PUBMED   2470025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121292.9.
            
            On Jan 18, 2022 this sequence version replaced NM_008210.5.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene contains introns and its mRNA is
            polyadenylated, unlike most histone genes. The protein encoded is a
            replication-independent member of the histone H3 family. [provided
            by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150468.1, AK150467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 9373943
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC121292.9         79273-79364
            93-243              AC121292.9         80886-81036
            244-397             AC121292.9         82565-82718
            398-1043            AC121292.9         89630-90275
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.46 cM"
     gene            1..1043
                     /gene="H3f3a"
                     /gene_synonym="EyeLinc14; H3-3a; H3-3b; H3.3A"
                     /note="H3.3 histone A"
                     /db_xref="GeneID:15078"
                     /db_xref="MGI:MGI:1097686"
     exon            1..92
                     /gene="H3f3a"
                     /gene_synonym="EyeLinc14; H3-3a; H3-3b; H3.3A"
                     /inference="alignment:Splign:2.1.0"
     exon            93..243
                     /gene="H3f3a"
                     /gene_synonym="EyeLinc14; H3-3a; H3-3b; H3.3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..526
                     /gene="H3f3a"
                     /gene_synonym="EyeLinc14; H3-3a; H3-3b; H3.3A"
                     /note="H3 histone, family 3A"
                     /codon_start=1
                     /product="histone H3.3"
                     /protein_id="NP_032236.1"
                     /db_xref="CCDS:CCDS15573.1"
                     /db_xref="GeneID:15078"
                     /db_xref="MGI:MGI:1097686"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
     exon            244..397
                     /gene="H3f3a"
                     /gene_synonym="EyeLinc14; H3-3a; H3-3b; H3.3A"
                     /inference="alignment:Splign:2.1.0"
     exon            398..1043
                     /gene="H3f3a"
                     /gene_synonym="EyeLinc14; H3-3a; H3-3b; H3.3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      860..865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3f3a"
                     /gene_synonym="EyeLinc14; H3-3a; H3-3b; H3.3A"
                     /note="hexamer: AGTAAA"
     polyA_site      882
                     /gene="H3f3a"
                     /gene_synonym="EyeLinc14; H3-3a; H3-3b; H3.3A"
                     /note="major polyA site"
     regulatory      1028..1033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3f3a"
                     /gene_synonym="EyeLinc14; H3-3a; H3-3b; H3.3A"
                     /note="hexamer: ATTAAA"
     polyA_site      1043
                     /gene="H3f3a"
                     /gene_synonym="EyeLinc14; H3-3a; H3-3b; H3.3A"
ORIGIN      
        1 caattgtgtt cgcagccttc gccgcgccgc tgccgctctc caacgccagc gccgcctctc
       61 gcttgccgag ctccagccga aggagaaggg gggtaagtaa ggaggtgtcc ttaccatggc
      121 tcgtacaaag cagactgccc gcaaatccac cggtggtaaa gcacccagga aacaactggc
      181 tacaaaagcc gctcgcaaga gtgcgccctc tactggaggg gtgaagaaac ctcatcgtta
      241 caggcctggt actgtggccc tccgtgaaat cagacgctat cagaagtcca ctgaacttct
      301 gatccgcaag ctcccctttc agcgtctggt gcgagaaatt gctcaggact tcaaaacaga
      361 tctgcgcttc cagagtgcag ctattggtgc tttgcaggag gcaagtgagg cctatctggt
      421 tggccttttt gaagatacca atctgtgtgc tatccatgcc aaacgtgtaa caattatgcc
      481 aaaagatatc cagctagcac gccgcatacg cggagaacgt gcttaagagt ccactatgag
      541 gggaaacatt tcattctcaa aaaaattttt tttcctcttc ttcctgttat cagtagttct
      601 gaatgttaga tattttttcc atggggtcaa aggtacctaa gtatatgatt gcgagtggaa
      661 acatagggga cagaatcagg tattggcgtt tctccacgtt catttgtgtg tgaattttta
      721 atataaatgc aagatggaaa gcattaatgc aagcaaaatg tttcagtgaa cacatttcaa
      781 cagttcaact ttataacaat tataaataaa cctgttaaaa ttttctggac aatgccagca
      841 tttggatttt tttaaaataa gtaaatttct tattgacggc aactaaatgg tgtttgtagc
      901 atttttatca cacagtagat tccatccatt cactatactt ttctaactga gttgtcctac
      961 atacaagtac atgtttttaa tgttgtcagt cttctgtgct gttcctgtaa gtttgctatt
     1021 aaaatacatt aaactatacc tgc
//
