LOCUS       NM_178205                911 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus H3 clustered histone 6 (H3c6), mRNA.
ACCESSION   NM_178205
VERSION     NM_178205.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 911)
  AUTHORS   Funaya,S., Takahashi,Y., Suzuki,M.G., Suzuki,Y. and Aoki,F.
  TITLE     H3.1/3.2 regulate the initial progression of the gene expression
            program
  JOURNAL   Nucleic Acids Res 52 (11), 6158-6170 (2024)
   PUBMED   38567720
  REMARK    GeneRIF: H3.1/3.2 regulate the initial progression of the gene
            expression program.
REFERENCE   2  (bases 1 to 911)
  AUTHORS   Wang,C., Huang,J., Li,Y., Zhang,J., He,C., Li,T., Jiang,D.,
            Dong,A., Ma,H., Copenhaver,G.P. and Wang,Y.
  TITLE     DNA polymerase epsilon binds histone H3.1-H4 and recruits MORC1 to
            mediate meiotic heterochromatin condensation
  JOURNAL   Proc Natl Acad Sci U S A 119 (43), e2213540119 (2022)
   PUBMED   36260743
  REMARK    GeneRIF: DNA polymerase epsilon binds histone H3.1-H4 and recruits
            MORC1 to mediate meiotic heterochromatin condensation.
REFERENCE   3  (bases 1 to 911)
  AUTHORS   Denoth-Lippuner,A., Jaeger,B.N., Liang,T., Royall,L.N., Chie,S.E.,
            Buthey,K., Machado,D., Korobeynyk,V.I., Kruse,M., Munz,C.M.,
            Gerbaulet,A., Simons,B.D. and Jessberger,S.
  TITLE     Visualization of individual cell division history in complex
            tissues using iCOUNT
  JOURNAL   Cell Stem Cell 28 (11), 2020-2034 (2021)
   PUBMED   34525348
REFERENCE   4  (bases 1 to 911)
  AUTHORS   Kawamura,M., Funaya,S., Sugie,K., Suzuki,M.G. and Aoki,F.
  TITLE     Asymmetrical deposition and modification of histone H3 variants are
            essential for zygote development
  JOURNAL   Life Sci Alliance 4 (8), e202101102 (2021)
   PUBMED   34168076
  REMARK    GeneRIF: Asymmetrical deposition and modification of histone H3
            variants are essential for zygote development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 911)
  AUTHORS   Ogoh,H., Yamagata,K., Nakao,T., Sandell,L.L., Yamamoto,A.,
            Yamashita,A., Tanga,N., Suzuki,M., Abe,T., Kitabayashi,I.,
            Watanabe,T. and Sakai,D.
  TITLE     Mllt10 knockout mouse model reveals critical role of Af10-dependent
            H3K79 methylation in midfacial development
  JOURNAL   Sci Rep 7 (1), 11922 (2017)
   PUBMED   28931923
  REMARK    GeneRIF: Together these data are the first to demonstrate that
            Af10-dependent H3K79me is essential for development of nasal
            processes and adjacent tissues, and consequent midfacial formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 911)
  AUTHORS   Santenard,A., Ziegler-Birling,C., Koch,M., Tora,L., Bannister,A.J.
            and Torres-Padilla,M.E.
  TITLE     Heterochromatin formation in the mouse embryo requires critical
            residues of the histone variant H3.3
  JOURNAL   Nat Cell Biol 12 (9), 853-862 (2010)
   PUBMED   20676102
REFERENCE   7  (bases 1 to 911)
  AUTHORS   Loyola,A., Bonaldi,T., Roche,D., Imhof,A. and Almouzni,G.
  TITLE     PTMs on H3 variants before chromatin assembly potentiate their
            final epigenetic state
  JOURNAL   Mol Cell 24 (2), 309-316 (2006)
   PUBMED   17052464
  REMARK    GeneRIF: analysis of histone posttranslational modifications on
            H3.1 and H3.3
REFERENCE   8  (bases 1 to 911)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 911)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   10 (bases 1 to 911)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592149.8.
            
            On Jul 12, 2019 this sequence version replaced NM_178205.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H3
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC127042.1, W64007.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-911               AL592149.8         42081-42991         c
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.79 cM"
     gene            1..911
                     /gene="H3c6"
                     /gene_synonym="H3-f; H3.1; H3c13; H3c14; H3c15; H3c2;
                     H3c3; H3c4; H3c7; Hist1h3e"
                     /note="H3 clustered histone 6"
                     /db_xref="GeneID:319151"
                     /db_xref="MGI:MGI:2448326"
     exon            1..911
                     /gene="H3c6"
                     /gene_synonym="H3-f; H3.1; H3c13; H3c14; H3c15; H3c2;
                     H3c3; H3c4; H3c7; Hist1h3e"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..431
                     /gene="H3c6"
                     /gene_synonym="H3-f; H3.1; H3c13; H3c14; H3c15; H3c2;
                     H3c3; H3c4; H3c7; Hist1h3e"
                     /note="histone 1, H3e; histone cluster 1, H3e;
                     H3-clustered histone 2; H3-clustered histone 3;
                     H3-clustered histone 4; H3-clustered histone 7;
                     H3-clustered histone 13; H3-clustered histone 14;
                     H3-clustered histone 15"
                     /codon_start=1
                     /product="histone H3.2"
                     /protein_id="NP_835512.1"
                     /db_xref="CCDS:CCDS26347.1"
                     /db_xref="GeneID:319151"
                     /db_xref="MGI:MGI:2448326"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
     polyA_site      488
                     /gene="H3c6"
                     /gene_synonym="H3-f; H3.1; H3c13; H3c14; H3c15; H3c2;
                     H3c3; H3c4; H3c7; Hist1h3e"
                     /note="major polyA site"
     regulatory      729..734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3c6"
                     /gene_synonym="H3-f; H3.1; H3c13; H3c14; H3c15; H3c2;
                     H3c3; H3c4; H3c7; Hist1h3e"
                     /note="hexamer: AGTAAA"
     polyA_site      750
                     /gene="H3c6"
                     /gene_synonym="H3-f; H3.1; H3c13; H3c14; H3c15; H3c2;
                     H3c3; H3c4; H3c7; Hist1h3e"
     regulatory      881..886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3c6"
                     /gene_synonym="H3-f; H3.1; H3c13; H3c14; H3c15; H3c2;
                     H3c3; H3c4; H3c7; Hist1h3e"
                     /note="hexamer: ATTAAA"
     polyA_site      911
                     /gene="H3c6"
                     /gene_synonym="H3-f; H3.1; H3c13; H3c14; H3c15; H3c2;
                     H3c3; H3c4; H3c7; Hist1h3e"
ORIGIN      
        1 cccgtttctc ctcctctgca atggctcgta ctaagcagac cgctcgcaag tccaccggcg
       61 gcaaggctcc gcgcaagcag ctggccacca aggccgcccg caagagcgcc ccggccaccg
      121 gcggcgtgaa gaagcctcac cgctaccgtc ccggcaccgt ggcgctgcgc gaaatccggc
      181 gctaccagaa gtcgaccgag ctgctgatcc gcaagctgcc gttccagcgc ctggtgcgcg
      241 agatcgcgca ggacttcaag accgacctgc gcttccagag ctcggccgtc atggctctgc
      301 aggaggcgag cgaggcctac ctcgtgggtc tgtttgagga caccaacctg tgcgccatcc
      361 acgccaagcg tgtcaccatc atgcccaagg acatccagct ggcccgccgt atccgcggcg
      421 agcgggctta ataggcacgc cttctacact ggcacgtaaa ccaaaacggc tcttttaaga
      481 gccacctcca ttatccacca aagatgctgt agtacaagtt tgtagagtgt tccagggttt
      541 cctattatat atagcctttc ttgacaatga tgagcaccac ccgacgaagc agtctgagct
      601 gcctgttttt ggaaacaagg ctttcaggat atcatttcat cttgtatgct ttcaactaga
      661 gttggggtag ccattttaag ccagaaacag gtacgcactt cagtttggga ttgtgttaca
      721 atccacacag taaaagtcca acagagttaa cgttttactt tgtttcacca ttcaaacttg
      781 ttacattgtt ggcatttcaa ttatttttac cttattttgg ttagttttgt ttttaaagca
      841 cgattctcct tgtctatggt ttccgttttc cttatctggg attaaaaagg tctgtgcctg
      901 gctcagttta t
//
