LOCUS       NM_178204                504 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H3 clustered histone 4 (H3c4), mRNA.
ACCESSION   NM_178204
VERSION     NM_178204.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Zhang,X., He,H., Yu,H., Teng,X., Wang,Z., Li,C., Li,J., Yang,H.,
            Shen,J., Wu,T., Zhang,F., Zhang,Y. and Wu,Q.
  TITLE     Maternal RNA transcription in Dlk1-Dio3 domain is critical for
            proper development of the mouse placental vasculature
  JOURNAL   Commun Biol 7 (1), 363 (2024)
   PUBMED   38521877
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Vetrivel,S., Truong,D.J., Wurst,W., Graw,J. and Giesert,F.
  TITLE     Identification of ocular regulatory functions of core histone
            variant H3.2
  JOURNAL   Exp Eye Res 226, 109346 (2023)
   PUBMED   36529279
REFERENCE   3  (bases 1 to 504)
  AUTHORS   Vetrivel,S., Tiso,N., Kugler,A., Irmler,M., Horsch,M., Beckers,J.,
            Hladik,D., Giesert,F., Gailus-Durner,V., Fuchs,H., Sabrautzki,S.,
            Hrabe de Angelis,M. and Graw,J.
  TITLE     Mutation in the mouse histone gene Hist2h3c1 leads to degeneration
            of the lens vesicle and severe microphthalmia
  JOURNAL   Exp Eye Res 188, 107632 (2019)
   PUBMED   30991053
REFERENCE   4  (bases 1 to 504)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   5  (bases 1 to 504)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
REFERENCE   6  (bases 1 to 504)
  AUTHORS   Moss,S.B., Ferry,R.A. and Groudine,M.
  TITLE     An alternative pathway of histone mRNA 3' end formation in mouse
            round spermatids
  JOURNAL   Nucleic Acids Res 22 (15), 3160-3166 (1994)
   PUBMED   8065931
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592149.8.
            
            On Feb 25, 2014 this sequence version replaced NM_178204.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H3
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK020421.1, BC069947.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-504               AL592149.8         56369-56872
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.8 cM"
     gene            1..504
                     /gene="H3c4"
                     /gene_synonym="H3-b; H3c13; H3c14; H3c15; H3c2; H3c3;
                     H3c6; H3c7; Hist1h3d"
                     /note="H3 clustered histone 4"
                     /db_xref="GeneID:319149"
                     /db_xref="MGI:MGI:2448322"
     exon            1..504
                     /gene="H3c4"
                     /gene_synonym="H3-b; H3c13; H3c14; H3c15; H3c2; H3c3;
                     H3c6; H3c7; Hist1h3d"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..450
                     /gene="H3c4"
                     /gene_synonym="H3-b; H3c13; H3c14; H3c15; H3c2; H3c3;
                     H3c6; H3c7; Hist1h3d"
                     /note="histone1, H3d; histone cluster 1, H3d; H3-clustered
                     histone 2; H3-clustered histone 3; H3-clustered histone 6;
                     H3-clustered histone 7; H3-clustered histone 13;
                     H3-clustered histone 14; H3-clustered histone 15"
                     /codon_start=1
                     /product="histone H3.2"
                     /protein_id="NP_835511.1"
                     /db_xref="CCDS:CCDS26352.1"
                     /db_xref="GeneID:319149"
                     /db_xref="MGI:MGI:2448322"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
ORIGIN      
        1 accgttctca ttccctgaga cttctctctt tttcttatca tggctcgtac taagcagacc
       61 gctcgcaagt ccaccggcgg caaggccccg cgcaagcagc tggccaccaa ggccgcccgc
      121 aagagcgccc cggccaccgg cggcgtgaag aagcctcacc gctaccgtcc cggcaccgtg
      181 gcgctgcgcg agatccggcg ctaccagaag tcgaccgagc tgctgatccg caagctgccg
      241 ttccagcgcc tggtgcgcga gatcgcgcag gacttcaaga ccgacctgcg cttccagagc
      301 tcggccgtca tggctctgca ggaggcgagc gaggcctacc tcgtgggtct gtttgaggac
      361 accaacctgt gtgccatcca cgccaagcgt gtcaccatca tgcccaagga catccagctg
      421 gcccgtcgca ttcgtgggga gagggcgtaa attagggtag tgagtgaatt tggaccccaa
      481 aggctctttt cagagccacc cccg
//
