LOCUS       NM_175653                480 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus H3 clustered histone 3 (H3c3), mRNA.
ACCESSION   NM_175653
VERSION     NM_175653.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Vetrivel,S., Truong,D.J., Wurst,W., Graw,J. and Giesert,F.
  TITLE     Identification of ocular regulatory functions of core histone
            variant H3.2
  JOURNAL   Exp Eye Res 226, 109346 (2023)
   PUBMED   36529279
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Vetrivel,S., Tiso,N., Kugler,A., Irmler,M., Horsch,M., Beckers,J.,
            Hladik,D., Giesert,F., Gailus-Durner,V., Fuchs,H., Sabrautzki,S.,
            Hrabe de Angelis,M. and Graw,J.
  TITLE     Mutation in the mouse histone gene Hist2h3c1 leads to degeneration
            of the lens vesicle and severe microphthalmia
  JOURNAL   Exp Eye Res 188, 107632 (2019)
   PUBMED   30991053
REFERENCE   3  (bases 1 to 480)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   4  (bases 1 to 480)
  AUTHORS   Brown,V.D., Wang,Z.F., Williams,A.S. and Marzluff,W.F.
  TITLE     Structure of a cluster of mouse histone genes
  JOURNAL   Biochim Biophys Acta 1306 (1), 17-22 (1996)
   PUBMED   8611618
REFERENCE   5  (bases 1 to 480)
  AUTHORS   Kaludov,N.K., Pabon-Pena,L. and Hurt,M.M.
  TITLE     Identification of a second conserved element within the coding
            sequence of a mouse H3 histone gene that interacts with nuclear
            factors and is necessary for normal expression
  JOURNAL   Nucleic Acids Res 24 (3), 523-531 (1996)
   PUBMED   8602367
REFERENCE   6  (bases 1 to 480)
  AUTHORS   DeBry,R.W. and Marzluff,W.F.
  TITLE     Selection on silent sites in the rodent H3 histone gene family
  JOURNAL   Genetics 138 (1), 191-202 (1994)
   PUBMED   8001786
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590388.4.
            
            On Feb 25, 2014 this sequence version replaced NM_175653.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H3
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AA049971.1, BC120800.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               AL590388.4         142857-143336
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.9 cM"
     gene            1..480
                     /gene="H3c3"
                     /gene_synonym="H3-143; H3c13; H3c14; H3c15; H3c2; H3c4;
                     H3c6; H3c7; Hist1h3c"
                     /note="H3 clustered histone 3"
                     /db_xref="GeneID:319148"
                     /db_xref="MGI:MGI:2448320"
     exon            1..480
                     /gene="H3c3"
                     /gene_synonym="H3-143; H3c13; H3c14; H3c15; H3c2; H3c4;
                     H3c6; H3c7; Hist1h3c"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..435
                     /gene="H3c3"
                     /gene_synonym="H3-143; H3c13; H3c14; H3c15; H3c2; H3c4;
                     H3c6; H3c7; Hist1h3c"
                     /note="histone1, H3c; histone cluster 1, H3c; H3-clustered
                     histone 2; H3-clustered histone 4; H3-clustered histone 6;
                     H3-clustered histone 7; H3-clustered histone 13;
                     H3-clustered histone 14; H3-clustered histone 15"
                     /codon_start=1
                     /product="histone H3.2"
                     /protein_id="NP_783584.1"
                     /db_xref="CCDS:CCDS26362.1"
                     /db_xref="GeneID:319148"
                     /db_xref="MGI:MGI:2448320"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
ORIGIN      
        1 acttttgtgt atctcctccc aagaatggct cgtactaagc agaccgctcg caagtccacc
       61 ggcggcaagg ccccgcgcaa gcagctggcc accaaagccg cccgcaagag cgccccggcc
      121 accggcggcg tgaagaagcc tcaccgctac cgtcccggca ccgtggcgct gcgcgagatc
      181 cggcgctacc agaagtcgac cgagctgctg atccgcaagc tgccgttcca gcgcctggtg
      241 cgcgagatcg cgcaggactt caagaccgac ctgcgcttcc agagctcggc tgtcatggct
      301 ctgcaggagg cgagcgaggc ctaccttgtg ggtctgtttg aggacaccaa cctgtgcgcc
      361 atccacgcca agcgtgtcac catcatgccc aaggacatcc agctcgcccg ccgcatccgc
      421 ggagagaggg cataatggtt tttatgctat ttaaaaaaag gctcttttaa gagccaccta
//
