LOCUS       NM_178203                496 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H3 clustered histone 2 (H3c2), mRNA.
ACCESSION   NM_178203
VERSION     NM_178203.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Vetrivel,S., Truong,D.J., Wurst,W., Graw,J. and Giesert,F.
  TITLE     Identification of ocular regulatory functions of core histone
            variant H3.2
  JOURNAL   Exp Eye Res 226, 109346 (2023)
   PUBMED   36529279
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Fortin,J., Tian,R., Zarrabi,I., Hill,G., Williams,E.,
            Sanchez-Duffhues,G., Thorikay,M., Ramachandran,P., Siddaway,R.,
            Wong,J.F., Wu,A., Apuzzo,L.N., Haight,J., You-Ten,A., Snow,B.E.,
            Wakeham,A., Goldhamer,D.J., Schramek,D., Bullock,A.N., Dijke,P.T.,
            Hawkins,C. and Mak,T.W.
  TITLE     Mutant ACVR1 Arrests Glial Cell Differentiation to Drive
            Tumorigenesis in Pediatric Gliomas
  JOURNAL   Cancer Cell 37 (3), 308-323 (2020)
   PUBMED   32142668
REFERENCE   3  (bases 1 to 496)
  AUTHORS   Vetrivel,S., Tiso,N., Kugler,A., Irmler,M., Horsch,M., Beckers,J.,
            Hladik,D., Giesert,F., Gailus-Durner,V., Fuchs,H., Sabrautzki,S.,
            Hrabe de Angelis,M. and Graw,J.
  TITLE     Mutation in the mouse histone gene Hist2h3c1 leads to degeneration
            of the lens vesicle and severe microphthalmia
  JOURNAL   Exp Eye Res 188, 107632 (2019)
   PUBMED   30991053
REFERENCE   4  (bases 1 to 496)
  AUTHORS   Jang,C.W., Shibata,Y., Starmer,J., Yee,D. and Magnuson,T.
  TITLE     Histone H3.3 maintains genome integrity during mammalian
            development
  JOURNAL   Genes Dev 29 (13), 1377-1392 (2015)
   PUBMED   26159997
REFERENCE   5  (bases 1 to 496)
  AUTHORS   Kawamura,M., Akiyama,T., Tsukamoto,S., Suzuki,M.G. and Aoki,F.
  TITLE     The expression and nuclear deposition of histone H3.1 in murine
            oocytes and preimplantation embryos
  JOURNAL   J Reprod Dev 58 (5), 557-562 (2012)
   PUBMED   22785220
REFERENCE   6  (bases 1 to 496)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 496)
  AUTHORS   Gruber,A., Streit,A., Reist,M., Benninger,P., Bohni,R. and
            Schumperli,D.
  TITLE     Structure of a mouse histone-encoding gene cluster
  JOURNAL   Gene 95 (2), 303-304 (1990)
   PUBMED   2249786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590388.4.
            
            On Jul 12, 2019 this sequence version replaced NM_178203.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H3
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7345562.1660107.1, W88216.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               AL590388.4         135538-136033       c
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.91 cM"
     gene            1..496
                     /gene="H3c2"
                     /gene_synonym="H3-53; H3c13; H3c14; H3c15; H3c3; H3c4;
                     H3c6; H3c7; Hist1h3b"
                     /note="H3 clustered histone 2"
                     /db_xref="GeneID:319150"
                     /db_xref="MGI:MGI:2448319"
     exon            1..496
                     /gene="H3c2"
                     /gene_synonym="H3-53; H3c13; H3c14; H3c15; H3c3; H3c4;
                     H3c6; H3c7; Hist1h3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..446
                     /gene="H3c2"
                     /gene_synonym="H3-53; H3c13; H3c14; H3c15; H3c3; H3c4;
                     H3c6; H3c7; Hist1h3b"
                     /note="histone 1, H3b; histone cluster 1, H3b;
                     H3-clustered histone 3; H3-clustered histone 4;
                     H3-clustered histone 6; H3-clustered histone 7;
                     H3-clustered histone 13; H3-clustered histone 14;
                     H3-clustered histone 15"
                     /codon_start=1
                     /product="histone H3.2"
                     /protein_id="NP_835510.1"
                     /db_xref="CCDS:CCDS26365.1"
                     /db_xref="GeneID:319150"
                     /db_xref="MGI:MGI:2448319"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
     regulatory      451..456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3c2"
                     /gene_synonym="H3-53; H3c13; H3c14; H3c15; H3c3; H3c4;
                     H3c6; H3c7; Hist1h3b"
                     /note="hexamer: AACAAA"
     polyA_site      496
                     /gene="H3c2"
                     /gene_synonym="H3-53; H3c13; H3c14; H3c15; H3c3; H3c4;
                     H3c6; H3c7; Hist1h3b"
                     /note="major polyA site"
ORIGIN      
        1 actatagtgt cagtctattt tcccttgtta aagtcatggc tcgtactaag cagaccgctc
       61 gcaagtccac cggcggcaag gccccgcgca agcagctggc caccaaggcc gcccgcaaga
      121 gcgccccggc caccggcggc gtgaagaagc ctcaccgcta ccgtcccggc accgtggcgc
      181 tgcgcgagat ccggcgctac cagaagtcga ccgagctgct gatccgcaag ctgccgttcc
      241 agcgcctggt gcgcgagatc gcgcaggact tcaagaccga cctgcgcttc cagagctcgg
      301 ccgtcatggc tctgcaggag gcgagcgagg cctaccttgt gggtctgttt gaggacacca
      361 acctgtgcgc catccacgcc aagcgtgtca ccatcatgcc caaggacatc cagctcgccc
      421 gccgcattcg tggggagagg gcttaaacga aacaaagtgc aaactggaac ccaaaggctc
      481 ttttcagagc caccca
//
