LOCUS       NM_054045                877 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus H3 clustered histone 15 (H3c15), mRNA.
ACCESSION   NM_054045 XM_977173
VERSION     NM_054045.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 877)
  AUTHORS   Vetrivel,S., Truong,D.J., Wurst,W., Graw,J. and Giesert,F.
  TITLE     Identification of ocular regulatory functions of core histone
            variant H3.2
  JOURNAL   Exp Eye Res 226, 109346 (2023)
   PUBMED   36529279
REFERENCE   2  (bases 1 to 877)
  AUTHORS   Vetrivel,S., Tiso,N., Kugler,A., Irmler,M., Horsch,M., Beckers,J.,
            Hladik,D., Giesert,F., Gailus-Durner,V., Fuchs,H., Sabrautzki,S.,
            Hrabe de Angelis,M. and Graw,J.
  TITLE     Mutation in the mouse histone gene Hist2h3c1 leads to degeneration
            of the lens vesicle and severe microphthalmia
  JOURNAL   Exp Eye Res 188, 107632 (2019)
   PUBMED   30991053
REFERENCE   3  (bases 1 to 877)
  AUTHORS   Quille,M.L., Carat,S., Quemener-Redon,S., Hirchaud,E., Baron,D.,
            Benech,C., Guihot,J., Placet,M., Mignen,O., Ferec,C., Houlgatte,R.
            and Friocourt,G.
  TITLE     High-throughput analysis of promoter occupancy reveals new targets
            for Arx, a gene mutated in mental retardation and
            interneuronopathies
  JOURNAL   PLoS One 6 (9), e25181 (2011)
   PUBMED   21966449
REFERENCE   4  (bases 1 to 877)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   5  (bases 1 to 877)
  AUTHORS   Taylor,J.D., Wellman,S.E. and Marzluff,W.F.
  TITLE     Sequences of four mouse histone H3 genes: implications for
            evolution of mouse histone genes
  JOURNAL   J Mol Evol 23 (3), 242-249 (1986)
   PUBMED   3027355
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125099.3.
            
            On Oct 6, 2022 this sequence version replaced NM_054045.4.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H3
            family. [provided by RefSeq, Aug 2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC015270.1, BF785771.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-877               AC125099.3         37070-37946
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.69 cM"
     gene            1..877
                     /gene="H3c15"
                     /gene_synonym="H3-614; H3.2-614; H3c13; H3c14; H3c2; H3c3;
                     H3c4; H3c6; H3c7; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1"
                     /note="H3 clustered histone 15"
                     /db_xref="GeneID:97114"
                     /db_xref="MGI:MGI:2448357"
     exon            1..877
                     /gene="H3c15"
                     /gene_synonym="H3-614; H3.2-614; H3c13; H3c14; H3c2; H3c3;
                     H3c4; H3c6; H3c7; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..454
                     /gene="H3c15"
                     /gene_synonym="H3-614; H3.2-614; H3c13; H3c14; H3c2; H3c3;
                     H3c4; H3c6; H3c7; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1"
                     /note="histone 2, H3c2; histone 2, H3ca2; histone cluster
                     2, H3c2, pseudogene; H3-clustered histone 2; H3-clustered
                     histone 3; H3-clustered histone 4; H3-clustered histone 6;
                     H3-clustered histone 7; H3-clustered histone 13;
                     H3-clustered histone 14"
                     /codon_start=1
                     /product="histone H3.2"
                     /protein_id="NP_473386.1"
                     /db_xref="CCDS:CCDS57240.1"
                     /db_xref="GeneID:97114"
                     /db_xref="MGI:MGI:2448357"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
     regulatory      848..853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H3c15"
                     /gene_synonym="H3-614; H3.2-614; H3c13; H3c14; H3c2; H3c3;
                     H3c4; H3c6; H3c7; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1"
                     /note="hexamer: ATTACA"
     polyA_site      877
                     /gene="H3c15"
                     /gene_synonym="H3-614; H3.2-614; H3c13; H3c14; H3c2; H3c3;
                     H3c4; H3c6; H3c7; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1"
                     /note="major polyA site"
ORIGIN      
        1 aggtccccga gtgctcctcg tttgggtgtc ttccgtcttc gccatggccc gtacgaagca
       61 gactgcccgc aagtccaccg gcggcaaggc cccgcgcaag cagctggcca ccaaggccgc
      121 ccgcaagagc gccccggcca cgggcggcgt gaagaagccg caccgctacc ggcccggcac
      181 cgtggcgctg cgggagatcc ggcgctacca gaagtcgacc gagctgctga tccgcaagct
      241 gccgttccag cgcctggtgc gcgagatcgc gcaggacttc aagacggacc tgcgcttcca
      301 gagctcggcc gtcatggcgc tgcaggaggc gagcgaggcc tacctggtgg ggctgttcga
      361 ggacaccaac ctgtgcgcca tccacgccaa acgcgtcacc atcatgccca aggacatcca
      421 gttggcccgc cgcatccgtg gggagcgcgc ttaagcgccc tgtctcccat ccattcccca
      481 caaaggctct tttcagagcc accacagctt cccggaaaga gctgtttact tcgcttagag
      541 ctttgtccgc acattatccc gctccatagc tctaggttgg tatctgactt atacctgtta
      601 tgtctacata atggttgctt tcaaggaagg tttgaatgcc cttagtgtaa gttgtttaac
      661 gttaattgcg gtcttattca gactcctagc ttgttaaccc gaagtaggtt caccacctca
      721 gtctaagggg aggggataat cttacggagg gttggggctt ggtggatact atgtaatgtt
      781 cctacccagc tggagcagag aaggctttgt aagtagctga aggctgagat ctagcttaca
      841 gctcataatt acatcaccag acttctggac gactgaa
//
