LOCUS       NM_178197                522 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus H2B clustered histone 9 (H2bc9), mRNA.
ACCESSION   NM_178197
VERSION     NM_178197.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Das,R., Burke,T. and Plow,E.F.
  TITLE     Histone H2B as a functionally important plasminogen receptor on
            macrophages
  JOURNAL   Blood 110 (10), 3763-3772 (2007)
   PUBMED   17690254
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Odegard,V.H., Kim,S.T., Anderson,S.M., Shlomchik,M.J. and
            Schatz,D.G.
  TITLE     Histone modifications associated with somatic hypermutation
  JOURNAL   Immunity 23 (1), 101-110 (2005)
   PUBMED   16039583
REFERENCE   3  (bases 1 to 522)
  AUTHORS   Fernandez-Capetillo,O., Allis,C.D. and Nussenzweig,A.
  TITLE     Phosphorylation of histone H2B at DNA double-strand breaks
  JOURNAL   J Exp Med 199 (12), 1671-1677 (2004)
   PUBMED   15197225
REFERENCE   4  (bases 1 to 522)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   5  (bases 1 to 522)
  AUTHORS   Sittman,D.B., Graves,R.A. and Marzluff,W.F.
  TITLE     Structure of a cluster of mouse histone genes
  JOURNAL   Nucleic Acids Res 11 (19), 6679-6697 (1983)
   PUBMED   6314253
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592149.8.
            
            On Feb 27, 2014 this sequence version replaced NM_178197.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC132586.1, CF739601.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-522               AL592149.8         23525-24046         c
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.78 cM"
     gene            1..522
                     /gene="H2bc9"
                     /gene_synonym="H2b-221; Hist1h2bh"
                     /note="H2B clustered histone 9"
                     /db_xref="GeneID:319182"
                     /db_xref="MGI:MGI:2448387"
     exon            1..522
                     /gene="H2bc9"
                     /gene_synonym="H2b-221; Hist1h2bh"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..473
                     /gene="H2bc9"
                     /gene_synonym="H2b-221; Hist1h2bh"
                     /note="histone 1, H2bh; histone cluster 1, H2bh"
                     /codon_start=1
                     /product="histone H2B type 1-H"
                     /protein_id="NP_835504.1"
                     /db_xref="CCDS:CCDS26343.1"
                     /db_xref="GeneID:319182"
                     /db_xref="MGI:MGI:2448387"
                     /translation="MPEPAKSAPAPKKGSKKALTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
ORIGIN      
        1 acaaggacag ccaccgcttt atttaaagag caggaaagga acggaacagt tcaatatctc
       61 ttttcttggc ctaccttcat tctctgttca ctatgcctga gcccgccaag tccgctcctg
      121 ccccgaagaa gggctccaag aaggccctga ccaaggccca gaagaaggac ggcaagaagc
      181 gcaagcgcag ccgcaaggag agctactcgg tgtacgtgta caaggtgctg aagcaagtgc
      241 accccgacac cggcatctcc tccaaagcca tgggcatcat gaactcgttc gtgaacgaca
      301 tcttcgagcg catcgcgggc gaggcgtccc gcctggcgca ttacaacaag cgctcgacca
      361 tcacgtcccg ggagatccag acggccgtgc gcctgctgct gcccggggag ctggccaagc
      421 acgccgtgtc ggagggcacc aaggctgtca ccaagtacac cagctccaag tgagtgctca
      481 agactcagct cttaacccaa aggctctttt cagagccact ca
//
