LOCUS       NM_001177653            2494 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus H2B clustered histone 6 (H2bc6), transcript variant 1,
            mRNA.
ACCESSION   NM_001177653
VERSION     NM_001177653.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2494)
  AUTHORS   Das,R., Burke,T. and Plow,E.F.
  TITLE     Histone H2B as a functionally important plasminogen receptor on
            macrophages
  JOURNAL   Blood 110 (10), 3763-3772 (2007)
   PUBMED   17690254
REFERENCE   2  (bases 1 to 2494)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592149.8.
            
            On Oct 24, 2022 this sequence version replaced NM_001177653.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene encodes a replication-dependent histone that
            is a member of the histone H2B family and generates multiple
            transcripts through alternative splicing, the use of the conserved
            stem-loop termination motif, and the polyA addition motif.
            [provided by RefSeq, Aug 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049948.1, SRR1660825.61310.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on conservation, expression,
                                             longest protein
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AL592149.8         101331-101523       c
            194-2494            AL592149.8         64085-66385         c
FEATURES             Location/Qualifiers
     source          1..2494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.81 cM"
     gene            1..2494
                     /gene="H2bc6"
                     /gene_synonym="Gm11398; H2bc4; H2bc8; Hist1h2be"
                     /note="H2B clustered histone 6"
                     /db_xref="GeneID:319179"
                     /db_xref="MGI:MGI:2448380"
     exon            1..193
                     /gene="H2bc6"
                     /gene_synonym="Gm11398; H2bc4; H2bc8; Hist1h2be"
                     /inference="alignment:Splign:2.1.0"
     exon            194..2494
                     /gene="H2bc6"
                     /gene_synonym="Gm11398; H2bc4; H2bc8; Hist1h2be"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..588
                     /gene="H2bc6"
                     /gene_synonym="Gm11398; H2bc4; H2bc8; Hist1h2be"
                     /note="histone 1, H2be; histone cluster 1, H2be"
                     /codon_start=1
                     /product="histone H2B type 1-C/E/G"
                     /protein_id="NP_001171124.1"
                     /db_xref="CCDS:CCDS26354.1"
                     /db_xref="GeneID:319179"
                     /db_xref="MGI:MGI:2448380"
                     /translation="MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
     regulatory      817..822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2bc6"
                     /gene_synonym="Gm11398; H2bc4; H2bc8; Hist1h2be"
                     /note="hexamer: AATAAA"
     polyA_site      847
                     /gene="H2bc6"
                     /gene_synonym="Gm11398; H2bc4; H2bc8; Hist1h2be"
                     /note="major polyA site"
     regulatory      2405..2410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2bc6"
                     /gene_synonym="Gm11398; H2bc4; H2bc8; Hist1h2be"
                     /note="hexamer: ATTAAA"
     polyA_site      2425
                     /gene="H2bc6"
                     /gene_synonym="Gm11398; H2bc4; H2bc8; Hist1h2be"
ORIGIN      
        1 ggagtaggta ttttaccaaa tgtttagtgt gcccaaggga gggagttaaa ttttacacaa
       61 tccctgagct ggcgaagtcc gagcctgccc cacagaagga ttcttagaag ctgccatcaa
      121 caaacagaag gacaaggagc gcaaacgcta ctgaaaggag agcttctagc aagtgtacaa
      181 cgtgctgaag cagaaagaga tctgaagatg cctgagccag ccaagtccgc tcccgccccg
      241 aagaagggct ccaagaaggc tgtcaccaag gcccagaaga aggacggcaa gaagcgcaag
      301 cgcagccgca aggagagcta ctcggtgtac gtgtacaagg tgctgaagca agtgcacccc
      361 gacaccggca tctcctccaa ggccatgggc atcatgaact cgttcgtgaa cgacatcttc
      421 gagcgcatcg cgggcgaggc gtcccgcctg gcgcattaca acaagcgctc gaccatcaca
      481 tcccgggaga tccagacggc cgtgcgcctg ctgctgcccg gggagctggc caagcacgcg
      541 gtgtcggagg gcaccaaggc tgtcaccaag tacaccagct ccaagtgagt tcatttaact
      601 cacactccta aaccaaaggc tcttttcaga gccacccaac agttcaaaat tgagctatgc
      661 gcttgttctt agtacccgca gtaccacctt tatatggttc tttatttact gggacaaagt
      721 tcctctagtc tattcaggct cgtcaaatca agtatttaag ataaaactgc caaattggct
      781 acttctgcag tgaagagagg ctacatttct gttctgaata aagaaccccg aacgtttcac
      841 actggcatct ccgagcgtcc agatccgtgg cgcacacatc cggtcttttg ttctaagtct
      901 ttctggggaa ttaacattgg cacgggaagg cgaggtggga ccgtgggttt actgcctggt
      961 ttagctaagc tacacaaaac ttaatttagc agcgtctcct aatttggatc aaaacgcagt
     1021 gttgtccgct cggtgcttgt taaactggtt ttcagtgacg ttcaggtcgc cattttatgc
     1081 ggcgccgccc tgaatggaga gagttctgtt cagctccctg aaagcgaaag tctcagcacg
     1141 aagggccagc tcgcgagtct accctcctaa ttcttaaaaa gttcctcact tccaaagacc
     1201 tagagctttt ggatttttag gcttttgcat atgaactaag ttgtaggaga agcaacaaga
     1261 tctccatttt aaaaaaacgt ttgctttgtt tactttttaa ttacaggaaa agatgaagtg
     1321 gtttgtaaag cctgcaaaca tttaatttcc ttccctttcc tgaactgctg ggtagttttt
     1381 ttaacaccaa gaaaattccc aaaaccctct cctgactcgt ttttgtaaag agacctggaa
     1441 aaaaaaaaat cagttcctag aatttagcca catcactttc tttgcaatta aggctgtgga
     1501 atgttagatg tggctctggg cactcccatc tctttaatct gccaggctct ggagtttaca
     1561 gcttctgagt ttgagctctt ggtccagcag ggagggaccc tgactcaatc ttgtgagaga
     1621 gaaaaagtag gaagtagaag tatcaggaag tgctgggtgt tggaagtatc acaggtattg
     1681 gggatggaac taaaggccca gttccagagc tagtcttgcc tccatccagc ctctaccatg
     1741 gctcccttct gaagctgggt aaagtgcctt tatgcaacat ccttcctaag ctttcaaaat
     1801 aaatacaaag aaactatcca ctttaaagta acaaaattgc aactgtactc caagaggcta
     1861 ctcactgtgt aaagtgtttt gccaccaaaa atgaacacct gagtatgtcc cctagcacct
     1921 acaaaatagg tcctctgacc tacagacatc ccagagcaaa tagaacacac acacacaatg
     1981 tgggtttttt ttaacggttt tttttttttt aattacaagt caactttact cacagttact
     2041 ttagaaacaa tactgaaact tccttgtgaa gagttaaacc ttcatggtaa tattttgttt
     2101 ccctttgttt tgtttagctg ttttctttgt aacaagattt cagtctgtag ccctggctac
     2161 cctgtaattc aactatgaaa cccaaactaa aactctctgc ttcacccttc taaatatgca
     2221 attataggtg tagatctcta caacttgtag tgttcctcct ttcttgtttg tgatttgttg
     2281 gtttgtttgt ttcttgggac aaagtatgaa actcactaaa ccaagctggc ctcatagact
     2341 tcagcctgac tgtctgctgt gcactggcat gtgtacctcc aagcctgctg ctgtactgtt
     2401 cattattaaa gcattcctga ttgaacctgc tgtgcactga aatgtgtact cccatgcctg
     2461 ctgttgtgtt ccttattaaa gcattcctga ttga
//
