LOCUS       NM_023422                728 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus H2B clustered histone 4 (H2bc4), transcript variant 1,
            mRNA.
ACCESSION   NM_023422
VERSION     NM_023422.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 728)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 728)
  AUTHORS   Scekic-Zahirovic,J., Sendscheid,O., El Oussini,H., Jambeau,M.,
            Sun,Y., Mersmann,S., Wagner,M., Dieterle,S., Sinniger,J.,
            Dirrig-Grosch,S., Drenner,K., Birling,M.C., Qiu,J., Zhou,Y., Li,H.,
            Fu,X.D., Rouaux,C., Shelkovnikova,T., Witting,A., Ludolph,A.C.,
            Kiefer,F., Storkebaum,E., Lagier-Tourenne,C. and Dupuis,L.
  TITLE     Toxic gain of function from mutant FUS protein is crucial to
            trigger cell autonomous motor neuron loss
  JOURNAL   EMBO J 35 (10), 1077-1097 (2016)
   PUBMED   26951610
REFERENCE   3  (bases 1 to 728)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   4  (bases 1 to 728)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   5  (bases 1 to 728)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   6  (bases 1 to 728)
  AUTHORS   Fernandez-Capetillo,O., Allis,C.D. and Nussenzweig,A.
  TITLE     Phosphorylation of histone H2B at DNA double-strand breaks
  JOURNAL   J Exp Med 199 (12), 1671-1677 (2004)
   PUBMED   15197225
REFERENCE   7  (bases 1 to 728)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 728)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 728)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   10 (bases 1 to 728)
  AUTHORS   Ingram,D.A., Hiatt,K., King,A.J., Fisher,L., Shivakumar,R.,
            Derstine,C., Wenning,M.J., Diaz,B., Travers,J.B., Hood,A.,
            Marshall,M., Williams,D.A. and Clapp,D.W.
  TITLE     Hyperactivation of p21(ras) and the hematopoietic-specific Rho
            GTPase, Rac2, cooperate to alter the proliferation of
            neurofibromin-deficient mast cells in vivo and in vitro
  JOURNAL   J Exp Med 194 (1), 57-69 (2001)
   PUBMED   11435472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK011516.1.
            
            On Apr 6, 2007 this sequence version replaced NM_023422.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene encodes a replication-dependent histone that
            is a member of the histone H2B family and generates two transcripts
            through the use of the conserved stem-loop termination motif, and
            the polyA addition motif. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longer, two
            exon transcript and contains a polyA signal and site. Variants 1
            and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011516.1, CA460632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on conservation, expression,
                                             longest protein
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-728               AK011516.1         3-730
FEATURES             Location/Qualifiers
     source          1..728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.87 cM"
     gene            1..728
                     /gene="H2bc4"
                     /gene_synonym="2610022J01Rik; H2bc6; H2bc8; H2bfs;
                     Hist1h2bc"
                     /note="H2B clustered histone 4"
                     /db_xref="GeneID:68024"
                     /db_xref="MGI:MGI:1915274"
     exon            1..423
                     /gene="H2bc4"
                     /gene_synonym="2610022J01Rik; H2bc6; H2bc8; H2bfs;
                     Hist1h2bc"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..414
                     /gene="H2bc4"
                     /gene_synonym="2610022J01Rik; H2bc6; H2bc8; H2bfs;
                     Hist1h2bc"
                     /note="histone 1, H2bc; H2B histone family, member S;
                     histone cluster 1, H2bc"
                     /codon_start=1
                     /product="histone H2B type 1-C/E/G"
                     /protein_id="NP_075911.2"
                     /db_xref="CCDS:CCDS26357.1"
                     /db_xref="GeneID:68024"
                     /db_xref="MGI:MGI:1915274"
                     /translation="MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
     exon            424..728
                     /gene="H2bc4"
                     /gene_synonym="2610022J01Rik; H2bc6; H2bc8; H2bfs;
                     Hist1h2bc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      566..571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2bc4"
                     /gene_synonym="2610022J01Rik; H2bc6; H2bc8; H2bfs;
                     Hist1h2bc"
                     /note="hexamer: TATAAA"
     regulatory      597..602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2bc4"
                     /gene_synonym="2610022J01Rik; H2bc6; H2bc8; H2bfs;
                     Hist1h2bc"
                     /note="hexamer: AAGAAA"
     polyA_site      598
                     /gene="H2bc4"
                     /gene_synonym="2610022J01Rik; H2bc6; H2bc8; H2bfs;
                     Hist1h2bc"
                     /note="major polyA site"
     polyA_site      641
                     /gene="H2bc4"
                     /gene_synonym="2610022J01Rik; H2bc6; H2bc8; H2bfs;
                     Hist1h2bc"
     polyA_site      661
                     /gene="H2bc4"
                     /gene_synonym="2610022J01Rik; H2bc6; H2bc8; H2bfs;
                     Hist1h2bc"
ORIGIN      
        1 cacactgagg ttcctgtgtt tggaaatccg aagatgcctg agcctgcgaa gtccgctccc
       61 gccccgaaga agggctccaa gaaggccgtg accaaggccc agaagaagga cggcaagaag
      121 cgcaagcgca gccgcaagga gagctactcg gtgtacgtgt acaaggtgct gaagcaagtg
      181 caccccgaca ccggcatctc ctccaaggcc atgggcatca tgaactcgtt cgtgaacgac
      241 atcttcgagc gcatcgcggg cgaggcgtcc cgcctggcgc attacaacaa gcgctcgacc
      301 atcacgtccc gggagatcca gacggccgtg cgcctgctgc tgcccgggga gctggccaag
      361 cacgcggtgt cggagggcac caaggccgtc accaagtaca ccagctccaa gtgatcctgc
      421 caagaggagc agacctgaca tcgtttgtac cactcaacag tgctggatgc tgtaacctca
      481 agacagtgca aatgggtgat actagcagat taaccaccat agtttcagaa ctcaaggaac
      541 aactgagaag caccatttta aattctataa aaatgttcac tgtagaaatt tgtgataaga
      601 aagacacaca gacgtagaaa atgagaatac ttgctgcaaa attaagatgc tcctagcaaa
      661 agaatgcttt taagtgtttg tcatgtatgg atatatatga tgtatatata ataaatgtca
      721 tgtaaagc
//
