LOCUS       NM_175664                490 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H2B clustered histone 3 (H2bc3), mRNA.
ACCESSION   NM_175664
VERSION     NM_175664.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Das,R., Burke,T. and Plow,E.F.
  TITLE     Histone H2B as a functionally important plasminogen receptor on
            macrophages
  JOURNAL   Blood 110 (10), 3763-3772 (2007)
   PUBMED   17690254
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Odegard,V.H., Kim,S.T., Anderson,S.M., Shlomchik,M.J. and
            Schatz,D.G.
  TITLE     Histone modifications associated with somatic hypermutation
  JOURNAL   Immunity 23 (1), 101-110 (2005)
   PUBMED   16039583
REFERENCE   3  (bases 1 to 490)
  AUTHORS   Fernandez-Capetillo,O., Allis,C.D. and Nussenzweig,A.
  TITLE     Phosphorylation of histone H2B at DNA double-strand breaks
  JOURNAL   J Exp Med 199 (12), 1671-1677 (2004)
   PUBMED   15197225
REFERENCE   4  (bases 1 to 490)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   5  (bases 1 to 490)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
REFERENCE   6  (bases 1 to 490)
  AUTHORS   Brown,V.D., Wang,Z.F., Williams,A.S. and Marzluff,W.F.
  TITLE     Structure of a cluster of mouse histone genes
  JOURNAL   Biochim Biophys Acta 1306 (1), 17-22 (1996)
   PUBMED   8611618
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590388.4.
            
            On Feb 25, 2014 this sequence version replaced NM_175664.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC116857.1, AA245006.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-490               AL590388.4         141155-141644       c
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.9 cM"
     gene            1..490
                     /gene="H2bc3"
                     /gene_synonym="H2b-143; Hist1h2bb"
                     /note="H2B clustered histone 3"
                     /db_xref="GeneID:319178"
                     /db_xref="MGI:MGI:2448377"
     exon            1..490
                     /gene="H2bc3"
                     /gene_synonym="H2b-143; Hist1h2bb"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..442
                     /gene="H2bc3"
                     /gene_synonym="H2b-143; Hist1h2bb"
                     /note="histone 1, H2bb; histone cluster 1, H2bb"
                     /codon_start=1
                     /product="histone H2B type 1-B"
                     /protein_id="NP_783595.1"
                     /db_xref="CCDS:CCDS26363.1"
                     /db_xref="GeneID:319178"
                     /db_xref="MGI:MGI:2448377"
                     /translation="MPEPSKSAPAPKKGSKKAISKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIASEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
     regulatory      458..463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2bc3"
                     /gene_synonym="H2b-143; Hist1h2bb"
                     /note="hexamer: AACAAA"
     polyA_site      490
                     /gene="H2bc3"
                     /gene_synonym="H2b-143; Hist1h2bb"
                     /note="major polyA site"
ORIGIN      
        1 ataagtgcgc cctcactgcc taccagtttc tgaccatttt gtgtgtcttc ttttgaacag
       61 aatgccagag ccttctaagt ctgcaccagc ccctaagaag ggatctaaga aagccatctc
      121 taaggcgcag aagaaggatg gcaagaagcg caagcgcagc cgcaaggaga gctattcggt
      181 gtacgtgtac aaggtgctga agcaagtgca ccccgacacc ggcatctcct ccaaggccat
      241 gggcatcatg aactcgttcg tgaacgacat cttcgagcgc atcgcgagcg aggcgtcccg
      301 cctggcgcat tacaacaagc gctcgaccat cacgtcccgg gagatccaga cggccgtgcg
      361 cctgctgctg cccggggagc tggccaagca cgccgtgtcg gagggcacta aggccgtcac
      421 caagtacacc agctccaagt gagctcgtag ggctcacaac aaacccaaag gctcttttaa
      481 gagccaccca
//
