LOCUS       NM_178202                624 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H2B clustered histone 22 (H2bc22), transcript variant
            1, mRNA.
ACCESSION   NM_178202
VERSION     NM_178202.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 624)
  AUTHORS   Das,R., Burke,T. and Plow,E.F.
  TITLE     Histone H2B as a functionally important plasminogen receptor on
            macrophages
  JOURNAL   Blood 110 (10), 3763-3772 (2007)
   PUBMED   17690254
REFERENCE   2  (bases 1 to 624)
  AUTHORS   Odegard,V.H., Kim,S.T., Anderson,S.M., Shlomchik,M.J. and
            Schatz,D.G.
  TITLE     Histone modifications associated with somatic hypermutation
  JOURNAL   Immunity 23 (1), 101-110 (2005)
   PUBMED   16039583
REFERENCE   3  (bases 1 to 624)
  AUTHORS   Fernandez-Capetillo,O., Allis,C.D. and Nussenzweig,A.
  TITLE     Phosphorylation of histone H2B at DNA double-strand breaks
  JOURNAL   J Exp Med 199 (12), 1671-1677 (2004)
   PUBMED   15197225
REFERENCE   4  (bases 1 to 624)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   5  (bases 1 to 624)
  AUTHORS   Moss,S.B., Challoner,P.B. and Groudine,M.
  TITLE     Expression of a novel histone 2B during mouse spermiogenesis
  JOURNAL   Dev Biol 133 (1), 83-92 (1989)
   PUBMED   2707490
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC061044.1 and AV047260.2.
            
            On Nov 17, 2007 this sequence version replaced NM_178202.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-dependent histone that
            is a member of the histone H2B family and generates two transcripts
            through the use of the conserved stem-loop termination motif, and
            the polyA addition motif. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061044.1, BU939366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on expression, longest
                                             protein
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               BC061044.1         1-591
            592-593             AV047260.2         299-300
            594-624             BC061044.1         594-624
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.97 cM"
     gene            1..624
                     /gene="H2bc22"
                     /gene_synonym="Hist1h2bp"
                     /note="H2B clustered histone 22"
                     /db_xref="GeneID:319188"
                     /db_xref="MGI:MGI:2448409"
     exon            1..404
                     /gene="H2bc22"
                     /gene_synonym="Hist1h2bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..444
                     /gene="H2bc22"
                     /gene_synonym="Hist1h2bp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone H2B type 1-P; histone 1, H2bp; histone cluster 1,
                     H2bp"
                     /codon_start=1
                     /product="histone H2B type 1-P isoform 1"
                     /protein_id="NP_835509.2"
                     /db_xref="CCDS:CCDS26298.2"
                     /db_xref="GeneID:319188"
                     /db_xref="MGI:MGI:2448409"
                     /translation="MPEPVKSVPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIASEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSKILWNKFYYLPSF"
     exon            405..594
                     /gene="H2bc22"
                     /gene_synonym="Hist1h2bp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      572..577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2bc22"
                     /gene_synonym="Hist1h2bp"
                     /note="hexamer: AATAAA"
     polyA_site      594
                     /gene="H2bc22"
                     /gene_synonym="Hist1h2bp"
                     /note="major polyA site"
ORIGIN      
        1 gtagcgtggt agagttcctg acctaacatg cctgagcctg ttaagtccgt tcccgccccg
       61 aagaagggct ccaagaaggc cgtcaccaag gcccaaaaga aggatggcaa gaagcgcaag
      121 cgcagccgca aggagagcta ctcggtgtac gtgtacaagg tgctgaagca agtgcacccc
      181 gacaccggca tctcctccaa ggccatgggc atcatgaact cgttcgtgaa cgacatcttc
      241 gagcgcatcg cgagcgaggc gtcccgcctg gcgcattaca acaagcgctc gaccatcacg
      301 tcccgggaga tccagacggc cgtgcgcctg ctgctgcccg gggagctggc caagcacgcg
      361 gtgtcggagg gcaccaaggc tgtcaccaag tacaccagct ccaaaatcct gtggaacaaa
      421 ttctattatc ttccttcctt ttaaagttga ggaaattaaa atgattgtac ggaagctgca
      481 acataaatag aggcttgtct gagtggagac cgaagtgtga actaccctcc acaatatgat
      541 cctgaaaaag aagtatttaa tacattataa aaataaaggt ttcaatctat cccaaaaaaa
      601 aaaaaaaaaa aaaaaaaaaa aaaa
//
