LOCUS       NM_178214               2623 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus H2B clustered histone 21 (H2bc21), mRNA.
ACCESSION   NM_178214
VERSION     NM_178214.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Feierman,E.R., Louzon,S., Prescott,N.A., Biaco,T., Gao,Q., Qiu,Q.,
            Choi,K., Palozola,K.C., Voss,A.J., Mehta,S.D., Quaye,C.N.,
            Lynch,K.T., Fuccillo,M.V., Wu,H., David,Y. and Korb,E.
  TITLE     Histone variant H2BE enhances chromatin accessibility in neurons to
            promote synaptic gene expression and long-term memory
  JOURNAL   Mol Cell 84 (15), 2822-2837 (2024)
   PUBMED   39025074
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Santoro,S.W. and Dulac,C.
  TITLE     The activity-dependent histone variant H2BE modulates the life span
            of olfactory neurons
  JOURNAL   Elife 1, e00070 (2012)
   PUBMED   23240083
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Wu,J., Chen,Y., Lu,L.Y., Wu,Y., Paulsen,M.T., Ljungman,M.,
            Ferguson,D.O. and Yu,X.
  TITLE     Chfr and RNF8 synergistically regulate ATM activation
  JOURNAL   Nat Struct Mol Biol 18 (7), 761-768 (2011)
   PUBMED   21706008
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Odegard,V.H., Kim,S.T., Anderson,S.M., Shlomchik,M.J. and
            Schatz,D.G.
  TITLE     Histone modifications associated with somatic hypermutation
  JOURNAL   Immunity 23 (1), 101-110 (2005)
   PUBMED   16039583
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Fernandez-Capetillo,O., Allis,C.D. and Nussenzweig,A.
  TITLE     Phosphorylation of histone H2B at DNA double-strand breaks
  JOURNAL   J Exp Med 199 (12), 1671-1677 (2004)
   PUBMED   15197225
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Wang,Z.F., Tisovec,R., Debry,R.W., Frey,M.R., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the 55-kb mouse histone gene cluster on
            chromosome 3
  JOURNAL   Genome Res 6 (8), 702-714 (1996)
   PUBMED   8858345
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Ko,M.S.
  TITLE     An 'equalized cDNA library' by the reassociation of short
            double-stranded cDNAs
  JOURNAL   Nucleic Acids Res 18 (19), 5705-5711 (1990)
   PUBMED   2216762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125099.3.
            
            On Jun 28, 2022 this sequence version replaced NM_178214.4.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene encodes a replication-dependent histone that
            is a member of the histone H2B family, and generates two
            transcripts through the use of a putative stem-loop termination
            motif, and the polyA addition motif. [provided by RefSeq, Aug
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC058562.1, AK167546.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2623              AC125099.3         52313-54935         c
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.67 cM"
     gene            1..2623
                     /gene="H2bc21"
                     /gene_synonym="H2b-613; Hist2h2be"
                     /note="H2B clustered histone 21"
                     /db_xref="GeneID:319190"
                     /db_xref="MGI:MGI:2448415"
     exon            1..2623
                     /gene="H2bc21"
                     /gene_synonym="H2b-613; Hist2h2be"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..428
                     /gene="H2bc21"
                     /gene_synonym="H2b-613; Hist2h2be"
                     /note="histone 2, H2be; histone cluster 2, H2be"
                     /codon_start=1
                     /product="histone H2B type 2-E"
                     /protein_id="NP_835586.2"
                     /db_xref="CCDS:CCDS17635.1"
                     /db_xref="GeneID:319190"
                     /db_xref="MGI:MGI:2448415"
                     /translation="MPELAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIANEASRLAHYNKRSTITSREIQTSVRLL
                     LPGELAKHAVSEGTKAVTKYTSAK"
     regulatory      2599..2604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2bc21"
                     /gene_synonym="H2b-613; Hist2h2be"
                     /note="hexamer: AATAAA"
     polyA_site      2623
                     /gene="H2bc21"
                     /gene_synonym="H2b-613; Hist2h2be"
                     /note="major polyA site"
ORIGIN      
        1 gttgattttc tacttactag actgttttcc actgtttgct tttaatcatg cctgaactgg
       61 ccaaatctgc cccggctccc aagaagggtt ccaagaaggc tgtcaccaag gcgcaaaaga
      121 aagatggcaa gaagcgcaag cgcagccgca aggagagcta ctccatctat gtgtacaaag
      181 tgctgaagca ggtgcacccg gacaccggca tctcgtccaa ggccatgggc atcatgaact
      241 cgtttgtcaa tgacatcttt gagcgcatag caaacgaggc ttctcgcctg gcgcattaca
      301 acaagcggtc tacaatcaca tcgcgggaga tccagacgtc ggtgcgcctt ctactgcccg
      361 gagaactggc caagcacgcc gtgtcggagg gcaccaaggc cgtcaccaag tacaccagcg
      421 ccaagtagag gcctccctgg atgaggcgct cgctggcccc tttgatcttt taaagtctct
      481 tttagtgagt cacccgctca aatcagaaga gagctttgcc acttgcatta gtttctagtt
      541 cctattccaa agttactcca agggtcttga aaagggtaca cttcagaagt tttaagcctt
      601 tgtggttttg agttcccctg tgggtatctg tttgcagttt gctgcaccct acttagcttc
      661 ttggagttct ttttagacta ggataatgga ggtgggtctc tgggcccggt ttccgtgttc
      721 taggcttttg gggtaccatt tacttgtcga cttaaagtga gatggtttcc ttaccctggc
      781 gaatagaggg ctccaggaca cagctaagac tgtgtcggcg aatgctgggt accagccatc
      841 tacaactgaa accgctctgt ccctttactt gtgtcctggg caccagcggt tacggggtac
      901 ttagggtggt gtccctctaa tttactgatt tacaaacacg aatgttccac gttgctgccg
      961 atttggtaga agtcggttat ggttctctat caggctttaa aatccctgtt cgaggcttgc
     1021 ttggtttgtt ttgttctgtt tttgtttttc cttttaattc tttgctttaa cctctgcagt
     1081 gccagattac cgcaggctac tgctgcttct ctgggctcat gaagcgatct ttcgaatcca
     1141 cacacgcagg aattagcttt ttccctcctg tcgtgtctcc aggagaagtt gtctcaagtt
     1201 ccctttgctt tcttatttac actgttgctg atcaagctgg gtctgacagt tttatacctc
     1261 cagagcccac cagtgcctca accacagcag atgctacttt taaaattact tattgaattc
     1321 atttttatac cactgctttt tttaaaatat atttttatta ggtattttca tttacatttc
     1381 aaaagctatc ccaaagtccc ccttaccctc cccacaacac tcccctaccc acccattctt
     1441 ggccctggtg ttcccttgta ctgaggcata taaagtttgc aagaccaagg ggcctatatc
     1501 actgcttttt aaaattactt attgaattaa tttttatatt aaggcggggg tggcagaggc
     1561 cttgtccatt tgatgtatgt gaagacacgt tggaaaggaa atgttttggg gatttttttc
     1621 ccaaatttgt ctttagttat cgttactgtg gtagctgttc ttggttctta gcccaagcag
     1681 ctgggtgcac ctgtgaggga tttatttttt cttagttcca taatttgaaa tgagaagaac
     1741 catttttaat ctggttcttt cccaccttta atctgggcca cgccagctgg cagcttctat
     1801 taaggacatg gaagaaggaa gcttgttctt tgcctgcttg ctggagatgg caagtctgtt
     1861 cctgaactgg cattagagcc ctacttactt gggattctgc catacactga agaccggctg
     1921 agacacccag ccttgtggac tgaacaacta ctggattatt ggaccttccg ttgggtgaca
     1981 gccattgaac cccagccatt gaactccagt aagccatgtg tttgtgttcg agtgtgtgtg
     2041 tgtgtttact agggactggc cgtaatagtt cccttaattt tgacaattta gaggaagctc
     2101 ttgggtttgt attaaatgga gcattggcct ttgggagaga gacattttac tgccaccatc
     2161 cccattctta atttttctat cctctactaa gatgaacttc caatttacaa ttgtcccaat
     2221 catttacatt tcagagggtc tacaggatag gtaggttatg gagcgaatag tgaaggtagt
     2281 agaagctaaa tagggaggtc cgtaggccaa cccctgcacc aataccatcc actcttgtct
     2341 cctacctgaa gacaacggcc ttggttttct tttgtgggga gtgtagcata ctgagttttt
     2401 cctttgaagt cttgattttg ttggtgaaga ttcttgatgg tctgattgct ttctcaattc
     2461 tgctttgtgg taagggttat tggagctgat tgcaggagct ttgtggatcc aaaagagagt
     2521 tccaaacatt gtcatagatc gaataaatcc attcactgca tgtgcatttt caagtgggta
     2581 gacactgtta ttattattaa taaagttacc gattagtttc aaa
//
