LOCUS       NM_175666                493 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H2B clustered histone 18 (H2bc18), mRNA.
ACCESSION   NM_175666
VERSION     NM_175666.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Doyle,H.A., Aswad,D.W. and Mamula,M.J.
  TITLE     Autoimmunity to isomerized histone H2B in systemic lupus
            erythematosus
  JOURNAL   Autoimmunity 46 (1), 6-13 (2013)
   PUBMED   22967069
  REMARK    GeneRIF: Autoimmunity to isoAsp H2B suggests that this form of the
            autoantigen may be critical in the induction of anti-histone
            autoantibodies in murine models of human SLE.
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Santoro,S.W. and Dulac,C.
  TITLE     The activity-dependent histone variant H2BE modulates the life span
            of olfactory neurons
  JOURNAL   Elife 1, e00070 (2012)
   PUBMED   23240083
  REMARK    GeneRIF: The activity-dependent histone variant H2BE modulates the
            life span of olfactory neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 493)
  AUTHORS   Das,R., Burke,T. and Plow,E.F.
  TITLE     Histone H2B as a functionally important plasminogen receptor on
            macrophages
  JOURNAL   Blood 110 (10), 3763-3772 (2007)
   PUBMED   17690254
  REMARK    GeneRIF: H2B plays a very prominent and functionally important role
            as plasminogen receptor.
REFERENCE   4  (bases 1 to 493)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   5  (bases 1 to 493)
  AUTHORS   Odegard,V.H., Kim,S.T., Anderson,S.M., Shlomchik,M.J. and
            Schatz,D.G.
  TITLE     Histone modifications associated with somatic hypermutation
  JOURNAL   Immunity 23 (1), 101-110 (2005)
   PUBMED   16039583
REFERENCE   6  (bases 1 to 493)
  AUTHORS   Fernandez-Capetillo,O., Allis,C.D. and Nussenzweig,A.
  TITLE     Phosphorylation of histone H2B at DNA double-strand breaks
  JOURNAL   J Exp Med 199 (12), 1671-1677 (2004)
   PUBMED   15197225
REFERENCE   7  (bases 1 to 493)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   8  (bases 1 to 493)
  AUTHORS   Bolognese,F., Imbriano,C., Caretti,G. and Mantovani,R.
  TITLE     Cloning and characterization of the histone-fold proteins YBL1 and
            YCL1
  JOURNAL   Nucleic Acids Res 28 (19), 3830-3838 (2000)
   PUBMED   11000277
REFERENCE   9  (bases 1 to 493)
  AUTHORS   Wang,Z.F., Tisovec,R., Debry,R.W., Frey,M.R., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the 55-kb mouse histone gene cluster on
            chromosome 3
  JOURNAL   Genome Res 6 (8), 702-714 (1996)
   PUBMED   8858345
REFERENCE   10 (bases 1 to 493)
  AUTHORS   Ko,M.S.
  TITLE     An 'equalized cDNA library' by the reassociation of short
            double-stranded cDNAs
  JOURNAL   Nucleic Acids Res 18 (19), 5705-5711 (1990)
   PUBMED   2216762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125099.3.
            
            On Jan 18, 2019 this sequence version replaced NM_175666.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene encodes a replication-dependent histone that
            is a member of the histone H2B family. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7345562.2184524.1,
                                        ERR3363658.5692255.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               AC125099.3         5862-6354           c
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.71 cM"
     gene            1..493
                     /gene="H2bc18"
                     /gene_synonym="H2b-616; Hist2h2bb"
                     /note="H2B clustered histone 18"
                     /db_xref="GeneID:319189"
                     /db_xref="MGI:MGI:2448413"
     exon            1..493
                     /gene="H2bc18"
                     /gene_synonym="H2b-616; Hist2h2bb"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..433
                     /gene="H2bc18"
                     /gene_synonym="H2b-616; Hist2h2bb"
                     /note="H2b 616; histone 2, H2bb; histone cluster 2, H2bb"
                     /codon_start=1
                     /product="histone H2B type 2-B"
                     /protein_id="NP_783597.2"
                     /db_xref="CCDS:CCDS57243.1"
                     /db_xref="GeneID:319189"
                     /db_xref="MGI:MGI:2448413"
                     /translation="MPDPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
     polyA_site      493
                     /gene="H2bc18"
                     /gene_synonym="H2b-616; Hist2h2bb"
                     /note="major polyA site"
ORIGIN      
        1 agttcgtagt tgcccggtct accttacgtt gcatctttag acgcggagga aaatgccgga
       61 tccagcgaag tctgctcctg ccccaaagaa gggctctaag aaagctgtca cgaaagtgca
      121 gaagaaagat ggcaagaagc gcaagcgcag ccgcaaggag agctattctg tttacgtgta
      181 caaggtcctg aagcaagtgc accccgacac gggcatctca tctaaggcta tgggaatcat
      241 gaattccttc gtgaacgata tcttcgagcg catcgcaggt gaggcttccc gtctggcgca
      301 ttacaacaag cgctcgacca tcacttcccg ggagatccag acagccgtgc gtctgctgct
      361 gccgggagag ttggctaaac acgctgtgtc ggaaggcacc aaggccgtca ccaagtacac
      421 cagctccaag tgaagtgcag cagagacgtg attgatcggc tttacccaaa aggctctttt
      481 cagagccact tta
//
