LOCUS       NM_178200                483 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H2B clustered histone 14 (H2bc14), mRNA.
ACCESSION   NM_178200
VERSION     NM_178200.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Das,R., Burke,T. and Plow,E.F.
  TITLE     Histone H2B as a functionally important plasminogen receptor on
            macrophages
  JOURNAL   Blood 110 (10), 3763-3772 (2007)
   PUBMED   17690254
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   3  (bases 1 to 483)
  AUTHORS   Odegard,V.H., Kim,S.T., Anderson,S.M., Shlomchik,M.J. and
            Schatz,D.G.
  TITLE     Histone modifications associated with somatic hypermutation
  JOURNAL   Immunity 23 (1), 101-110 (2005)
   PUBMED   16039583
REFERENCE   4  (bases 1 to 483)
  AUTHORS   Fernandez-Capetillo,O., Allis,C.D. and Nussenzweig,A.
  TITLE     Phosphorylation of histone H2B at DNA double-strand breaks
  JOURNAL   J Exp Med 199 (12), 1671-1677 (2004)
   PUBMED   15197225
REFERENCE   5  (bases 1 to 483)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   6  (bases 1 to 483)
  AUTHORS   Liu,T.J., Liu,L. and Marzluff,W.F.
  TITLE     Mouse histone H2A and H2B genes: four functional genes and a
            pseudogene undergoing gene conversion with a closely linked
            functional gene
  JOURNAL   Nucleic Acids Res 15 (7), 3023-3039 (1987)
   PUBMED   3562244
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL589651.8.
            
            On Mar 13, 2014 this sequence version replaced NM_178200.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2B
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC139382.1, AA198726.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-483               AL589651.8         143034-143516
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.94 cM"
     gene            1..483
                     /gene="H2bc14"
                     /gene_synonym="H2b-291b; Hist1h2bm"
                     /note="H2B clustered histone 14"
                     /db_xref="GeneID:319186"
                     /db_xref="MGI:MGI:2448404"
     exon            1..483
                     /gene="H2bc14"
                     /gene_synonym="H2b-291b; Hist1h2bm"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..435
                     /gene="H2bc14"
                     /gene_synonym="H2b-291b; Hist1h2bm"
                     /note="H2B 291B; histone cluster 1, H2bm; histone 1, H2bm"
                     /codon_start=1
                     /product="histone H2B type 1-M"
                     /protein_id="NP_835507.1"
                     /db_xref="CCDS:CCDS26290.1"
                     /db_xref="GeneID:319186"
                     /db_xref="MGI:MGI:2448404"
                     /translation="MPEPTKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLL
                     LPGELAKHAVSEGTKAVTKYTSSK"
     polyA_site      483
                     /gene="H2bc14"
                     /gene_synonym="H2b-291b; Hist1h2bm"
                     /note="major polyA site"
ORIGIN      
        1 gcgttcactt cgcctcctct atacagacaa attgcagttt atctgtgttg taacatgcct
       61 gagccaacga agtccgctcc cgccccgaag aagggctcca agaaggccgt caccaaggcc
      121 cagaagaagg atggcaagaa gcgcaagcgc agccgcaagg agagctactc ggtgtacgtg
      181 tacaaggtgc taaagcaagt gcaccccgac accggcatct cctccaaggc catgggcatc
      241 atgaactcgt tcgtgaacga catcttcgag cgcatcgcag gcgaggcttc ccgcctggcg
      301 cattacaaca agcgctcgac catcacgtcc cgggagatcc agacggccgt gcgcctgctg
      361 ctgcccgggg agctggccaa gcacgcggtg tcggagggca ccaaggcggt caccaagtac
      421 accagctcca agtgagttcg tctgactcac tccaaacaca aaggctcttt tcagagccac
      481 taa
//
