LOCUS       NM_175663                432 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus H2B clustered histone 1 (H2bc1), mRNA.
ACCESSION   NM_175663
VERSION     NM_175663.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 432)
  AUTHORS   Singh,I. and Parte,P.
  TITLE     Genome-wide profiling of the epigenetic landscape of histone
            variant TH2B in murine oocytes and pre-implantation embryos
  JOURNAL   Reproduction 169 (1), e240035 (2025)
   PUBMED   39447008
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 432)
  AUTHORS   Robson,A., Makova,S.Z., Barish,S., Zaidi,S., Mehta,S., Drozd,J.,
            Jin,S.C., Gelb,B.D., Seidman,C.E., Chung,W.K., Lifton,R.P.,
            Khokha,M.K. and Brueckner,M.
  TITLE     Histone H2B monoubiquitination regulates heart development via
            epigenetic control of cilia motility
  JOURNAL   Proc Natl Acad Sci U S A 116 (28), 14049-14054 (2019)
   PUBMED   31235600
  REMARK    GeneRIF: These data suggest that Rnf20 functions at the Rfx3 locus
            regulating cilia motility and cardiac situs and identify H2Bub1 as
            an upstream transcriptional regulator controlling tissue-specific
            expression of cilia genes. Our findings mechanistically link the
            two functional gene ontologies that have been implicated in human
            CHD: chromatin remodeling and cilia function.
REFERENCE   3  (bases 1 to 432)
  AUTHORS   Beedle,M.T., Topping,T., Hogarth,C. and Griswold,M.
  TITLE     Differential localization of histone variant TH2B during the first
            round compared with subsequent rounds of spermatogenesis
  JOURNAL   Dev Dyn 248 (6), 488-500 (2019)
   PUBMED   30939211
  REMARK    GeneRIF: TH2B and ZBTB16 co-localize in the neonatal testis. Upon
            the appearance of the primary spermatocytes, TH2B no longer
            co-localized with the ZBTB16 positive spermatogonia but were
            instead detected within the differentiating spermatogonia.
REFERENCE   4  (bases 1 to 432)
  AUTHORS   Barral,S., Morozumi,Y., Tanaka,H., Montellier,E., Govin,J., de
            Dieuleveult,M., Charbonnier,G., Coute,Y., Puthier,D., Buchou,T.,
            Boussouar,F., Urahama,T., Fenaille,F., Curtet,S., Hery,P.,
            Fernandez-Nunez,N., Shiota,H., Gerard,M., Rousseaux,S.,
            Kurumizaka,H. and Khochbin,S.
  TITLE     Histone Variant H2A.L.2 Guides Transition Protein-Dependent
            Protamine Assembly in Male Germ Cells
  JOURNAL   Mol Cell 66 (1), 89-101 (2017)
   PUBMED   28366643
REFERENCE   5  (bases 1 to 432)
  AUTHORS   Tarcic,O., Pateras,I.S., Cooks,T., Shema,E., Kanterman,J.,
            Ashkenazi,H., Boocholez,H., Hubert,A., Rotkopf,R., Baniyash,M.,
            Pikarsky,E., Gorgoulis,V.G. and Oren,M.
  TITLE     RNF20 Links Histone H2B Ubiquitylation with Inflammation and
            Inflammation-Associated Cancer
  JOURNAL   Cell Rep 14 (6), 1462-1476 (2016)
   PUBMED   26854224
  REMARK    GeneRIF: RNF20 and H2Bub1 promotes chronic colonic inflammation and
            inflammation-associated colorectal cancer in mice and humans,
            partly by augmenting NF-kappaB activity and attenuating the
            antitumoral T cell response.
REFERENCE   6  (bases 1 to 432)
  AUTHORS   Das,R., Burke,T. and Plow,E.F.
  TITLE     Histone H2B as a functionally important plasminogen receptor on
            macrophages
  JOURNAL   Blood 110 (10), 3763-3772 (2007)
   PUBMED   17690254
REFERENCE   7  (bases 1 to 432)
  AUTHORS   Govin,J., Escoffier,E., Rousseaux,S., Kuhn,L., Ferro,M.,
            Thevenon,J., Catena,R., Davidson,I., Garin,J., Khochbin,S. and
            Caron,C.
  TITLE     Pericentric heterochromatin reprogramming by new histone variants
            during mouse spermiogenesis
  JOURNAL   J Cell Biol 176 (3), 283-294 (2007)
   PUBMED   17261847
REFERENCE   8  (bases 1 to 432)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   9  (bases 1 to 432)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
REFERENCE   10 (bases 1 to 432)
  AUTHORS   Choi,Y.C., Gu,W., Hecht,N.B., Feinberg,A.P. and Chae,C.B.
  TITLE     Molecular cloning of mouse somatic and testis-specific H2B histone
            genes containing a methylated CpG island
  JOURNAL   DNA Cell Biol 15 (6), 495-504 (1996)
   PUBMED   8672246
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL606464.11.
            
            On Feb 21, 2014 this sequence version replaced NM_175663.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene contain a palindromic
            termination element. [provided by RefSeq, Aug 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC126923.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               AL606464.11        52650-53081         c
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 10.0 cM"
     gene            1..432
                     /gene="H2bc1"
                     /gene_synonym="Hist1h2ba; Th2b"
                     /note="H2B clustered histone 1"
                     /db_xref="GeneID:319177"
                     /db_xref="MGI:MGI:2448375"
     exon            1..432
                     /gene="H2bc1"
                     /gene_synonym="Hist1h2ba; Th2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..384
                     /gene="H2bc1"
                     /gene_synonym="Hist1h2ba; Th2b"
                     /note="histone H2B, testis; testis-specific histone H2B;
                     histone 1, H2ba; histone cluster 1, H2ba"
                     /codon_start=1
                     /product="histone H2B type 1-A"
                     /protein_id="NP_783594.1"
                     /db_xref="CCDS:CCDS26373.1"
                     /db_xref="GeneID:319177"
                     /db_xref="MGI:MGI:2448375"
                     /translation="MPEVAVKGATISKKGFKKAVTKTQKKEGRKRKRCRKESYSIYIY
                     KVLKQVHPDTGISSKAMSIMNSFVTDIFERIASEASRLAHYNKRSTITSREIQTAVRL
                     LLPGELAKHAVSEGTKAVTKYTSSK"
ORIGIN      
        1 atgccggagg tggcggtaaa gggtgctact atttccaaga aaggcttcaa gaaagcggtc
       61 accaagaccc agaaaaagga gggccggaaa cgtaagagat gccgcaagga gagctactcc
      121 atttacatct ataaggtgct gaaacaagtg caccccgaca ccggcatctc ctccaaggcc
      181 atgagcatca tgaactcctt tgtgacagac atcttcgagc gcatcgcgag cgaggcgtcc
      241 cgcctggcgc attacaacaa gcgctcgacc atcacgtccc gggagatcca gacggccgtg
      301 cgcctgctgc tgcccgggga gctggccaag cacgcggtgt cggagggcac caaggccgtc
      361 accaagtaca ccagctccaa gtgagctcgc agggctcaca acaaacccaa aggctctttt
      421 aagagccacc ca
//
