LOCUS       NM_029938               1636 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus H2A.Z histone variant 2 (H2az2), transcript variant 1,
            mRNA.
ACCESSION   NM_029938 XM_001476068 XM_907680
VERSION     NM_029938.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1636)
  AUTHORS   Tan,J., Duron,A., Sucov,H.M. and Makita,T.
  TITLE     Placode and neural crest origins of congenital deafness in mouse
            models of Waardenburg-Shah syndrome
  JOURNAL   iScience 28 (1), 111680 (2024)
   PUBMED   39868048
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1636)
  AUTHORS   He,X.D., Taylor,L.F., Miao,X., Shi,Y., Lin,X., Yang,Z., Liu,X.,
            Miao,Y.L., Alfandari,D., Cui,W., Tremblay,K.D. and Mager,J.
  TITLE     Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2
            despite distinct functions during early mouse developmentdagger
  JOURNAL   Biol Reprod 111 (5), 1017-1029 (2024)
   PUBMED   39194072
REFERENCE   3  (bases 1 to 1636)
  AUTHORS   Houchen,C.J., Ghanem,S., Kaartinen,V. and Bumann,E.E.
  TITLE     TGF-beta signaling in the cranial neural crest affects late-stage
            mandibular bone resorption and length
  JOURNAL   Front Physiol 15, 1435594 (2024)
   PUBMED   39473613
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1636)
  AUTHORS   Zhu,S., Huo,S., Wang,Z., Huang,C., Li,C., Song,H., Yang,X., He,R.,
            Ding,C., Qiu,M. and Zhu,X.J.
  TITLE     Follistatin controls the number of murine teeth by limiting
            TGF-beta signaling
  JOURNAL   iScience 27 (9), 110785 (2024)
   PUBMED   39286503
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1636)
  AUTHORS   Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
            Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
            Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
            Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
  TITLE     Motor innervation directs the correct development of the mouse
            sympathetic nervous system
  JOURNAL   Nat Commun 15 (1), 7065 (2024)
   PUBMED   39152112
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1636)
  AUTHORS   Dryhurst,D., Ishibashi,T., Rose,K.L., Eirin-Lopez,J.M.,
            McDonald,D., Silva-Moreno,B., Veldhoen,N., Helbing,C.C.,
            Hendzel,M.J., Shabanowitz,J., Hunt,D.F. and Ausio,J.
  TITLE     Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in
            vertebrates
  JOURNAL   BMC Biol 7, 86 (2009)
   PUBMED   20003410
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1636)
  AUTHORS   Brault,V., Moore,R., Kutsch,S., Ishibashi,M., Rowitch,D.H.,
            McMahon,A.P., Sommer,L., Boussadia,O. and Kemler,R.
  TITLE     Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion
            results in dramatic brain malformation and failure of craniofacial
            development
  JOURNAL   Development 128 (8), 1253-1264 (2001)
   PUBMED   11262227
REFERENCE   8  (bases 1 to 1636)
  AUTHORS   Chai,Y., Jiang,X., Ito,Y., Bringas,P. Jr., Han,J., Rowitch,D.H.,
            Soriano,P., McMahon,A.P. and Sucov,H.M.
  TITLE     Fate of the mammalian cranial neural crest during tooth and
            mandibular morphogenesis
  JOURNAL   Development 127 (8), 1671-1679 (2000)
   PUBMED   10725243
REFERENCE   9  (bases 1 to 1636)
  AUTHORS   Jiang,X., Rowitch,D.H., Soriano,P., McMahon,A.P. and Sucov,H.M.
  TITLE     Fate of the mammalian cardiac neural crest
  JOURNAL   Development 127 (8), 1607-1616 (2000)
   PUBMED   10725237
REFERENCE   10 (bases 1 to 1636)
  AUTHORS   Danielian,P.S., Muccino,D., Rowitch,D.H., Michael,S.K. and
            McMahon,A.P.
  TITLE     Modification of gene activity in mouse embryos in utero by a
            tamoxifen-inducible form of Cre recombinase
  JOURNAL   Curr Biol 8 (24), 1323-1326 (1998)
   PUBMED   9843687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ069840.1, BC147294.1 and
            AL646020.15.
            
            On or before Aug 29, 2009 this sequence version replaced
            XM_907680.3, XM_001476068.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H2A family. [provided by RefSeq,
            Nov 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ069840.1, FO713747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on conservation,
                                               expression
            replication-independent histone :: PMID: 20003410
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CJ069840.1         2-16
            16-551              BC147294.1         1-536
            552-1636            AL646020.15        4033-5117           c
FEATURES             Location/Qualifiers
     source          1..1636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.01 cM"
     gene            1..1636
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /note="H2A.Z histone variant 2"
                     /db_xref="GeneID:77605"
                     /db_xref="MGI:MGI:1924855"
     exon            1..107
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..491
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone H2A.F/Z; histone H2A.V; H2A histone family, member
                     V; H2A.Z variant histone 2"
                     /codon_start=1
                     /product="histone H2A.V isoform 1"
                     /protein_id="NP_084214.1"
                     /db_xref="CCDS:CCDS48750.1"
                     /db_xref="GeneID:77605"
                     /db_xref="MGI:MGI:1924855"
                     /translation="MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSH
                     GRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIK
                     ATIAGGGVIPHIHKSLIGKKGQQKTA"
     exon            108..185
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /inference="alignment:Splign:2.1.0"
     exon            186..299
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /inference="alignment:Splign:2.1.0"
     exon            300..429
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /inference="alignment:Splign:2.1.0"
     exon            430..1636
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /inference="alignment:Splign:2.1.0"
     regulatory      704..709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /note="hexamer: GATAAA"
     polyA_site      724
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /note="major polyA site"
     regulatory      1609..1614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /note="hexamer: AAGAAA"
     polyA_site      1633
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
ORIGIN      
        1 gaggcgggcc ccgggcattg tcccgctctg gctgcggcgg tccgactgcg agagcggcgg
       61 cggcggcggc gcggggctgc agtgggcgtc gcgcggccga gaccatggct ggaggcaaag
      121 ctggaaaaga cagtgggaag gccaaggcta aggcggtgtc tcgttcccag cgagctgggc
      181 tccagtttcc tgtgggccgc atccacagac acttgaagac tcgcaccaca agccatggac
      241 gggtgggcgc cactgctgct gtgtacagtg ccgcaattct ggagtacctc acagctgagg
      301 tgttggagtt agcaggtaat gcttccaaag atctcaaagt gaagcgcatc accccacgtc
      361 acttacagct tgcaatccgc ggtgatgaag agttggattc tcttatcaag gccaccatag
      421 ccgggggcgg cgtgatcccg cacatccaca agtctctgat tggaaagaag gggcagcaga
      481 aaactgctta ggacgtgagt cgctggcctg ctctcctcgg tctgtaacag ggcagagggg
      541 actagtgcgg tgtgcggaag agcatagacg gttgctgtag acgagacaaa ggccacatct
      601 gtatgttttt agactcggag tttgatgagt ccctttccct gtggtcacag tcatgtgttg
      661 attggccagg tttctccctt gtgttttata caaaagtaga attgataaaa cattttttac
      721 aaaagtactg tgtctcagta tttcttcatg atgtattaga aatacttttt tcaaacctgg
      781 ccagggccat gttgcctgca tccccagcgt ttgggaggtg tgggcaggac cttcagaata
      841 cacgctgatc tctgcctaca ttccaagttc taccacaacc tggactacat attctcttca
      901 gacattgacg ttttaagata ttcagaataa tcttaaagca aaaattggaa tgtagtatac
      961 cttgattgtt acagtgttag tttgaatctc agatataatc aatttttaga aatatatatt
     1021 tattaacgta tacagtgttc tgcctgccta tatgcctgca agccataaga aagcaccaga
     1081 tcccattaca gaccattggg agccaccatg tgggtgctgg gaactgaact caggacctct
     1141 gcaagagctg ccagtgatct taacctctcc agcccttatc aaggagtgtt attagcctac
     1201 tttatgggca tgctgcccat tgtccacagg aggtaatgat ctgctgagaa gacagttgag
     1261 ctggtagatg ggtcagtgca gttggacaca agcctaggtc tgtctggctt cagagtgcac
     1321 acaggagtga tgctactaag ttagactttt ctgattgggt cctggaattc taactttgtg
     1381 tggccattca tcgatcccac taacctgcag tgacttacag cctttatgat tgatgtctaa
     1441 gtgactacaa gatgtaaact aattcactag taaatgcgat agccaaaatt ttatttttct
     1501 tcaatatgtc tttgtgagaa attaatgttt tataatatca cagtatcaaa acaattcatt
     1561 tttgaagaaa tattttatta tggaagttct gacaaatgca cagaaataaa gaaactagca
     1621 ctagtgtgac aaagcc
//
