LOCUS       NM_016750               1069 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus H2A.Z variant histone 1 (H2az1), transcript variant 1,
            mRNA.
ACCESSION   NM_016750 XM_917450 XM_924958 XM_924959
VERSION     NM_016750.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1069)
  AUTHORS   He,X.D., Taylor,L.F., Miao,X., Shi,Y., Lin,X., Yang,Z., Liu,X.,
            Miao,Y.L., Alfandari,D., Cui,W., Tremblay,K.D. and Mager,J.
  TITLE     Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2
            despite distinct functions during early mouse developmentdagger
  JOURNAL   Biol Reprod 111 (5), 1017-1029 (2024)
   PUBMED   39194072
REFERENCE   2  (bases 1 to 1069)
  AUTHORS   Reda,A., Hategan,L.A., McLean,T.A.B., Creighton,S.D., Luo,J.Q.,
            Chen,S.E.S., Hua,S., Winston,S., Reeves,I., Padmanabhan,A.,
            Dahi,T.A., Ramzan,F., Brimble,M.A., Murphy,P.J., Walters,B.J.,
            Stefanelli,G. and Zovkic,I.B.
  TITLE     Role of the histone variant H2A.Z.1 in memory, transcription, and
            alternative splicing is mediated by lysine modification
  JOURNAL   Neuropsychopharmacology 49 (8), 1285-1295 (2024)
   PUBMED   38366138
REFERENCE   3  (bases 1 to 1069)
  AUTHORS   Belotti,E., Lacoste,N., Iftikhar,A., Simonet,T., Papin,C.,
            Osseni,A., Streichenberger,N., Mari,P.O., Girard,E., Graies,M.,
            Giglia-Mari,G., Dimitrov,S., Hamiche,A. and Schaeffer,L.
  TITLE     H2A.Z is involved in premature aging and DSB repair initiation in
            muscle fibers
  JOURNAL   Nucleic Acids Res 52 (6), 3031-3049 (2024)
   PUBMED   38281187
  REMARK    GeneRIF: H2A.Z is involved in premature aging and DSB repair
            initiation in muscle fibers.
REFERENCE   4  (bases 1 to 1069)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1069)
  AUTHORS   Li,Y., Li,Z., Wang,C., Yang,M., He,Z., Wang,F., Zhang,Y., Li,R.,
            Gong,Y., Wang,B., Fan,B., Wang,C., Chen,L., Li,H., Shi,P., Wang,N.,
            Wei,Z., Wang,Y.L., Jin,L., Du,P., Dong,J. and Jiao,J.
  TITLE     Spatiotemporal transcriptome atlas reveals the regional
            specification of the developing human brain
  JOURNAL   Cell 186 (26), 5892-5909 (2023)
   PUBMED   38091994
REFERENCE   6  (bases 1 to 1069)
  AUTHORS   Shaytan,A.K., Landsman,D. and Panchenko,A.R.
  TITLE     Nucleosome adaptability conferred by sequence and structural
            variations in histone H2A-H2B dimers
  JOURNAL   Curr Opin Struct Biol 32, 48-57 (2015)
   PUBMED   25731851
  REMARK    Review article
REFERENCE   7  (bases 1 to 1069)
  AUTHORS   Chadwick,B.P. and Willard,H.F.
  TITLE     Histone H2A variants and the inactive X chromosome: identification
            of a second macroH2A variant
  JOURNAL   Hum Mol Genet 10 (10), 1101-1113 (2001)
   PUBMED   11331621
REFERENCE   8  (bases 1 to 1069)
  AUTHORS   Choi,D.K., Suzuki,Y., Yoshimura,S., Togashi,T., Hida,M.,
            Taylor,T.D., Wang,Y., Sugano,S., Hattori,M. and Sakaki,Y.
  TITLE     Molecular cloning and characterization of a gene expressed in mouse
            developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down
            syndrome Critical Region gene 5)
  JOURNAL   Mamm Genome 12 (5), 347-351 (2001)
   PUBMED   11331941
REFERENCE   9  (bases 1 to 1069)
  AUTHORS   Misawa,K., Nosaka,T., Morita,S., Kaneko,A., Nakahata,T., Asano,S.
            and Kitamura,T.
  TITLE     A method to identify cDNAs based on localization of green
            fluorescent protein fusion products
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3062-3066 (2000)
   PUBMED   10716735
REFERENCE   10 (bases 1 to 1069)
  AUTHORS   Pantazis,P. and Bonner,W.M.
  TITLE     Quantitative determination of histone modification. H2A acetylation
            and phosphorylation
  JOURNAL   J Biol Chem 256 (9), 4669-4675 (1981)
   PUBMED   7217105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125154.3.
            
            On May 15, 2014 this sequence version replaced NM_016750.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent member of
            the histone H2A family that is distinct from other members of the
            family. Studies in mice have shown that this particular histone is
            required for embryonic development and indicate that lack of
            functional histone H2A leads to embryonic lethality. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U70494.1, AK146181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            replication-independent histone :: PMID: 25731851
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC125154.3         179823-180032
            211-288             AC125154.3         180469-180546
            289-402             AC125154.3         180856-180969
            403-532             AC125154.3         181347-181476
            533-1069            AC125154.3         181722-182258
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 63.94 cM"
     gene            1..1069
                     /gene="H2az1"
                     /gene_synonym="H2A.Z; H2a.z-1; H2A.Z1; H2afz"
                     /note="H2A.Z variant histone 1"
                     /db_xref="GeneID:51788"
                     /db_xref="MGI:MGI:1888388"
     exon            1..210
                     /gene="H2az1"
                     /gene_synonym="H2A.Z; H2a.z-1; H2A.Z1; H2afz"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..594
                     /gene="H2az1"
                     /gene_synonym="H2A.Z; H2a.z-1; H2A.Z1; H2afz"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone H2A.Z; H2A histone family, member Z"
                     /codon_start=1
                     /product="histone H2A.Z isoform 1"
                     /protein_id="NP_058030.1"
                     /db_xref="CCDS:CCDS38647.1"
                     /db_xref="GeneID:51788"
                     /db_xref="MGI:MGI:1888388"
                     /translation="MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSH
                     GRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIK
                     ATIAGGGVIPHIHKSLIGKKGQQKTV"
     exon            211..288
                     /gene="H2az1"
                     /gene_synonym="H2A.Z; H2a.z-1; H2A.Z1; H2afz"
                     /inference="alignment:Splign:2.1.0"
     exon            289..402
                     /gene="H2az1"
                     /gene_synonym="H2A.Z; H2a.z-1; H2A.Z1; H2afz"
                     /inference="alignment:Splign:2.1.0"
     exon            403..532
                     /gene="H2az1"
                     /gene_synonym="H2A.Z; H2a.z-1; H2A.Z1; H2afz"
                     /inference="alignment:Splign:2.1.0"
     exon            533..1069
                     /gene="H2az1"
                     /gene_synonym="H2A.Z; H2a.z-1; H2A.Z1; H2afz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      949..954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2az1"
                     /gene_synonym="H2A.Z; H2a.z-1; H2A.Z1; H2afz"
                     /note="hexamer: AATAAA"
     polyA_site      971
                     /gene="H2az1"
                     /gene_synonym="H2A.Z; H2a.z-1; H2A.Z1; H2afz"
     regulatory      1044..1049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2az1"
                     /gene_synonym="H2A.Z; H2a.z-1; H2A.Z1; H2afz"
                     /note="hexamer: ATTAAA"
     polyA_site      1069
                     /gene="H2az1"
                     /gene_synonym="H2A.Z; H2a.z-1; H2A.Z1; H2afz"
                     /note="major polyA site"
ORIGIN      
        1 gtcccgaggg cgggaggcaa ccattggtgg gccgaaccgg ccgagttccc ggatgaggga
       61 acattctgca gtataaaggg cgcgaggaag gcgggagacg gcgcagtttg aatcgcggtc
      121 cgacggagga gtgggcgctg ggatctcgct gagcgtccgc ctggcctcgt ctcttcctcg
      181 ctcgtcggag cttcagcacg gtccgagatg gctggcggta aggctggaaa ggactccgga
      241 aaggccaaga caaaggcggt ttcccgctcg cagcgagccg gcttgcagtt ccctgtgggc
      301 cgtattcatc gacacctgaa atctaggaca accagccacg gacgtgtggg cgcgaccgcc
      361 gctgtgtaca gcgcagccat cctggagtac ctcaccgcag aggtacttga gttggcagga
      421 aatgcgtcaa aagacttaaa ggtaaagcgt atcacccctc gtcacttgca gcttgctata
      481 cgtggagatg aagaattgga ttctctgatc aaagctacca ttgctggtgg tggtgtcatc
      541 ccacacatcc acaaatcgct gatcgggaag aaaggacaac agaagactgt ttaaggatgc
      601 ctggattcct tattatctca ggactctaaa tattcctaac agctgtccag tgttggtgat
      661 tccagtggac tgtatctctg tgaaaaacac aattttgcct ttttgtaatt ctatttgagc
      721 aagttggagg cttaattagc cttccaacca accaaatttc tgcattcgag tcttaaccat
      781 atttaagtgt tactgtggct tcaaagaagc tattgattct gaagtagtgg gttttgattg
      841 agttgactgt ttttaaaaaa ctgtttggat tttaattgtg atgcagaagt tatagtaaca
      901 agcatttggt tttgtacaga cattgtttcc actctggtgg ataagctcaa taaaggtcat
      961 atcccaaact agctttaaac ttgcttaata atcgggactt accttagatc tcactcagca
     1021 acaagtacat tctctgctta ctaattaaac agtgcatctg tagtcataa
//
