LOCUS       NM_026627                542 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus H2A histone family member L2A (H2al2a), mRNA.
ACCESSION   NM_026627
VERSION     NM_026627.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 542)
  AUTHORS   Ge,T., Yuan,L., Xu,L., Yang,F., Xu,W., Niu,C., Li,G., Zhou,H. and
            Zheng,Y.
  TITLE     Coiled-coil domain containing 159 is required for spermatid head
            and tail assembly in micedagger
  JOURNAL   Biol Reprod 110 (5), 877-894 (2024)
   PUBMED   38236177
REFERENCE   2  (bases 1 to 542)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 542)
  AUTHORS   Barral,S., Morozumi,Y., Tanaka,H., Montellier,E., Govin,J., de
            Dieuleveult,M., Charbonnier,G., Coute,Y., Puthier,D., Buchou,T.,
            Boussouar,F., Urahama,T., Fenaille,F., Curtet,S., Hery,P.,
            Fernandez-Nunez,N., Shiota,H., Gerard,M., Rousseaux,S.,
            Kurumizaka,H. and Khochbin,S.
  TITLE     Histone Variant H2A.L.2 Guides Transition Protein-Dependent
            Protamine Assembly in Male Germ Cells
  JOURNAL   Mol Cell 66 (1), 89-101 (2017)
   PUBMED   28366643
  REMARK    GeneRIF: The incorporation of H2A.L.2 initiates and orchestrates a
            series of successive transitional states that ultimately shift to
            the fully compacted genome of the mature spermatozoa.
REFERENCE   4  (bases 1 to 542)
  AUTHORS   Shaytan,A.K., Landsman,D. and Panchenko,A.R.
  TITLE     Nucleosome adaptability conferred by sequence and structural
            variations in histone H2A-H2B dimers
  JOURNAL   Curr Opin Struct Biol 32, 48-57 (2015)
   PUBMED   25731851
  REMARK    Review article
REFERENCE   5  (bases 1 to 542)
  AUTHORS   Gu,C.H., Tian,F.Y., Pu,J.R., Zheng,L.D., Mei,H., Zeng,F.Q.,
            Yang,J.J., Kan,Q.C. and Tong,Q.S.
  TITLE     Over-expression of testis-specific expressed gene 1 attenuates the
            proliferation and induces apoptosis of GC-1spg cells
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 34 (4), 535-541 (2014)
   PUBMED   25135723
  REMARK    GeneRIF: These results indicated over-expression of TSEG-1
            suppresses the proliferation and induces the apoptosis of GC-1spg
            cells, which establishes a basis for further study on the function
            of TSEG-
REFERENCE   6  (bases 1 to 542)
  AUTHORS   Sansoni,V., Casas-Delucchi,C.S., Rajan,M., Schmidt,A., Bonisch,C.,
            Thomae,A.W., Staege,M.S., Hake,S.B., Cardoso,M.C. and Imhof,A.
  TITLE     The histone variant H2A.Bbd is enriched at sites of DNA synthesis
  JOURNAL   Nucleic Acids Res 42 (10), 6405-6420 (2014)
   PUBMED   24753410
REFERENCE   7  (bases 1 to 542)
  AUTHORS   Gu,C., Tong,Q., Zheng,L., Liang,Z., Pu,J., Mei,H., Hu,T., Du,Z.,
            Tian,F. and Zeng,F.
  TITLE     TSEG-1, a novel member of histone H2A variants, participates in
            spermatogenesis via promoting apoptosis of spermatogenic cells
  JOURNAL   Genomics 95 (5), 278-289 (2010)
   PUBMED   20188161
REFERENCE   8  (bases 1 to 542)
  AUTHORS   Syed,S.H., Boulard,M., Shukla,M.S., Gautier,T., Travers,A.,
            Bednar,J., Faivre-Moskalenko,C., Dimitrov,S. and Angelov,D.
  TITLE     The incorporation of the novel histone variant H2AL2 confers
            unusual structural and functional properties of the nucleosome
  JOURNAL   Nucleic Acids Res 37 (14), 4684-4695 (2009)
   PUBMED   19506029
  REMARK    GeneRIF: The unusual properties of the H2AL2 nucleosomes suggest a
            specific role of H2AL2 during mouse spermiogenesis.
REFERENCE   9  (bases 1 to 542)
  AUTHORS   Gu,C.H., Tong,Q.S., Zeng,F.Q., Liu,Y., Wang,Z.Y., Zheng,L.D.,
            Cai,J.B. and Jiang,G.S.
  TITLE     [Cloning and sequence analysis of TSEG-1, a novel gene specifically
            expressed in mouse testis]
  JOURNAL   Yi Chuan 30 (3), 352-358 (2008)
   PUBMED   18332006
  REMARK    GeneRIF: Results indicated that TSEG-1 was cloned from X
            chromosome, with full-length sequence of 510 bp. The ORF is 336 bp
            that en-codes a deduced amino acid sequence of 111 residues. It was
            distinctively expressed in testis, but not in other tissues . :
            [TSEG-1]
REFERENCE   10 (bases 1 to 542)
  AUTHORS   Govin,J., Escoffier,E., Rousseaux,S., Kuhn,L., Ferro,M.,
            Thevenon,J., Catena,R., Davidson,I., Garin,J., Khochbin,S. and
            Caron,C.
  TITLE     Pericentric heterochromatin reprogramming by new histone variants
            during mouse spermiogenesis
  JOURNAL   J Cell Biol 176 (3), 283-294 (2007)
   PUBMED   17261847
  REMARK    GeneRIF: H2AL1 and H2AL2, specifically mark the pericentric regions
            in condensing spermatids and participate in the formation of new
            nucleoprotein structures
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL928589.11.
            
            On Sep 17, 2015 this sequence version replaced NM_026627.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H2A family. [provided by RefSeq,
            Nov 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC061062.1, AB074873.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 25731851
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               AL928589.11        121691-122232       c
FEATURES             Location/Qualifiers
     source          1..542
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 12.81 cM"
     gene            1..542
                     /gene="H2al2a"
                     /gene_synonym="1700113O17Rik; H2A.Bbd; H2A.L.2; H2ab1;
                     H2afb1; H2al2; TSEG-1; Tseg1"
                     /note="H2A histone family member L2A"
                     /db_xref="GeneID:68231"
                     /db_xref="MGI:MGI:1915481"
     exon            1..542
                     /gene="H2al2a"
                     /gene_synonym="1700113O17Rik; H2A.Bbd; H2A.L.2; H2ab1;
                     H2afb1; H2al2; TSEG-1; Tseg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..421
                     /gene="H2al2a"
                     /gene_synonym="1700113O17Rik; H2A.Bbd; H2A.L.2; H2ab1;
                     H2afb1; H2al2; TSEG-1; Tseg1"
                     /note="testis-specific expressed protein 1; H2A Barr
                     body-deficient; testis-specific expressed gene 1 protein;
                     histone variant H2al2; histone H2Alike 2; histone H2A-like
                     2; H2A histone family, member B1"
                     /codon_start=1
                     /product="histone H2A-Bbd type 1"
                     /protein_id="NP_080903.1"
                     /db_xref="CCDS:CCDS38050.1"
                     /db_xref="GeneID:68231"
                     /db_xref="MGI:MGI:1915481"
                     /translation="MARKRQRRRRRKVTRSQRAELQFPVSRVDRFLREGNYSRRLSSS
                     APVFLAGVLEYLTSNILELAGEVAHTTGRKRIAPEHVCRVVQNNEQLHQLFKQGGTSV
                     FEPPEPDDN"
     regulatory      515..520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2al2a"
                     /gene_synonym="1700113O17Rik; H2A.Bbd; H2A.L.2; H2ab1;
                     H2afb1; H2al2; TSEG-1; Tseg1"
                     /note="hexamer: ATTAAA"
     polyA_site      542
                     /gene="H2al2a"
                     /gene_synonym="1700113O17Rik; H2A.Bbd; H2A.L.2; H2ab1;
                     H2afb1; H2al2; TSEG-1; Tseg1"
                     /note="major polyA site"
ORIGIN      
        1 ataggtgggt gagaaggctg gttatttgga gagcctggta ccaaccacag agggtcagct
       61 gagcaaaaac caccacacaa gcatcatggc caggaaaagg caaaggcgaa gaagacggaa
      121 agtgacccgc tcccagagag ctgagcttca atttcctgtt agccgtgtgg atcgtttcct
      181 acgagaggga aactattcta gacgcctgag ctcttctgct cctgtattcc tcgcgggtgt
      241 gctcgagtac ttaacatcta acatccttga actggctggt gaggtggccc acaccactgg
      301 caggaagcgc atagctccag agcatgtgtg ccgtgtggta cagaacaacg aacagctcca
      361 ccaactcttc aaacaaggtg gcacatcagt gtttgagcca ccagaacctg atgacaactg
      421 atgatgcctg ggtctcgagt ctggaggttc accgcacttt cagccttacc cagctccaat
      481 gtcctactag ctgggggagc taatcaaaca tgctattaaa gcatttacat cgaacccatt
      541 ga
//
