LOCUS       NM_177688               1827 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H2J.A histone (H2aj), mRNA.
ACCESSION   NM_177688 XM_906486
VERSION     NM_177688.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Abd Al-Razaq,M.A., Freyter,B.M., Isermann,A., Tewary,G.,
            Mangelinck,A., Mann,C. and Rube,C.E.
  TITLE     Role of Histone Variant H2A.J in Fine-Tuning Chromatin Organization
            for the Establishment of Ionizing Radiation-Induced Senescence
  JOURNAL   Cells 12 (6), 916 (2023)
   PUBMED   36980257
  REMARK    GeneRIF: Role of Histone Variant H2A.J in Fine-Tuning Chromatin
            Organization for the Establishment of Ionizing Radiation-Induced
            Senescence.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1827)
  AUTHORS   Liu,B., Wang,J., Wang,G., Jiang,W., Li,Z., Shi,Y., Zhang,J.,
            Pei,Q., Huang,G., Wang,L., Zhao,S., Wu,L., Zhang,M., Wang,W.,
            Li,X., Mou,T., Zhang,C. and Ding,Q.
  TITLE     Hepatocyte-derived exosomes deliver H2AFJ to hepatic stellate cells
            and promote liver fibrosis via the MAPK/STMN1 axis activation
  JOURNAL   Int Immunopharmacol 115, 109605 (2023)
   PUBMED   36608439
  REMARK    GeneRIF: Hepatocyte-derived exosomes deliver H2AFJ to hepatic
            stellate cells and promote liver fibrosis via the MAPK/STMN1 axis
            activation.
REFERENCE   3  (bases 1 to 1827)
  AUTHORS   Rube,C.E., Baumert,C., Schuler,N., Isermann,A., Schmal,Z.,
            Glanemann,M., Mann,C. and Scherthan,H.
  TITLE     Human skin aging is associated with increased expression of the
            histone variant H2A.J in the epidermis
  JOURNAL   NPJ Aging Mech Dis 7 (1), 7 (2021)
   PUBMED   33795696
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1827)
  AUTHORS   Mallika,C., Guo,Q. and Li,J.Y.
  TITLE     Gbx2 is essential for maintaining thalamic neuron identity and
            repressing habenular characters in the developing thalamus
  JOURNAL   Dev Biol 407 (1), 26-39 (2015)
   PUBMED   26297811
REFERENCE   5  (bases 1 to 1827)
  AUTHORS   Dai,N., Zhao,L., Wrighting,D., Kramer,D., Majithia,A., Wang,Y.,
            Cracan,V., Borges-Rivera,D., Mootha,V.K., Nahrendorf,M.,
            Thorburn,D.R., Minichiello,L., Altshuler,D. and Avruch,J.
  TITLE     IGF2BP2/IMP2-Deficient mice resist obesity through enhanced
            translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial
            proteins
  JOURNAL   Cell Metab 21 (4), 609-621 (2015)
   PUBMED   25863250
REFERENCE   6  (bases 1 to 1827)
  AUTHORS   Nishida,H., Suzuki,T., Tomaru,Y. and Hayashizaki,Y.
  TITLE     A novel replication-independent histone H2a gene in mouse
  JOURNAL   BMC Genet 6, 10 (2005)
   PUBMED   15720718
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV498351.1, BC099606.1 and
            AK053755.1.
            
            On or before Aug 8, 2008 this sequence version replaced
            XM_906486.3, NM_177688.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is located on chromosome 6 and encodes a
            replication-independent histone that is member of the histone H2A
            family. [provided by RefSeq, Nov 2015].
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 15720718
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AV498351.1         1-18
            19-547              BC099606.1         1-529
            548-1349            AK053755.1         473-1274
            1350-1827           AK053755.1         1277-1754
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 66.72 cM"
     gene            1..1827
                     /gene="H2aj"
                     /gene_synonym="E130307C13; H2afj"
                     /note="H2J.A histone"
                     /db_xref="GeneID:232440"
                     /db_xref="MGI:MGI:3606192"
     exon            1..1827
                     /gene="H2aj"
                     /gene_synonym="E130307C13; H2afj"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..482
                     /gene="H2aj"
                     /gene_synonym="E130307C13; H2afj"
                     /note="H2a/j; H2A histone family, member J"
                     /codon_start=1
                     /product="histone H2A.J"
                     /protein_id="NP_808356.1"
                     /db_xref="CCDS:CCDS20654.1"
                     /db_xref="GeneID:232440"
                     /db_xref="MGI:MGI:3606192"
                     /translation="MSGRGKQGGKVRAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESQKVKSK"
     regulatory      527..532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2aj"
                     /gene_synonym="E130307C13; H2afj"
                     /note="hexamer: AATAAA"
     polyA_site      551
                     /gene="H2aj"
                     /gene_synonym="E130307C13; H2afj"
                     /note="major polyA site"
     regulatory      1804..1809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2aj"
                     /gene_synonym="E130307C13; H2afj"
                     /note="hexamer: AATAAA"
     polyA_site      1823
                     /gene="H2aj"
                     /gene_synonym="E130307C13; H2afj"
ORIGIN      
        1 gcggctgcag tttggcgagg cagttccggg gtggcgcgcg tcgtcccgga actgagcgag
       61 ccggtgttgg agttccaggc gcggggtcga gcatgtccgg gcgaggcaag cagggcggta
      121 aggtgcgcgc caaggccaag tcgcgctcgt cgcgcgcggg cctgcagttc cccgtgggcc
      181 gcgttcaccg gctgctgcgg aagggcaact acgcggagcg cgtgggcgcg ggagcgcccg
      241 tgtacctggc ggcggtgctg gagtacctga cggccgagat cctggagctg gcgggcaacg
      301 cggcgaggga caacaagaag acgcgcatca tccctcgtca cctgcagctg gccatccgca
      361 acgacgagga gctcaacaag ctgctgggcc gtgtgaccat cgcgcagggc ggcgtcctgc
      421 ccaatatcca ggccgtgctg ctgcccaaga agacggagag ccagaaggtg aagagcaagt
      481 gaacccgaca gacgggtgca gagcccgccc gccacagtcc gcagccaata aagtcggtga
      541 aaagcgagta atctagagag ctgtgtagtc gcgggaccga gggggtgttg ggtggggacg
      601 agttccaact ttgagcgtga cgcaggccac ctgtgtggcc atgtgcgagc cggaggaacc
      661 cagcgggtgg attgggagag ccccgtcgca tcaccgtggg caggagaagc ggacctagtg
      721 cccagaggct actctggaat tggctttgcc taactcccca gtcttaggga aaagtggtag
      781 ggaaggtgtt gcgagctgtg aacaagaagt tgcctcgctt gtcatacata ggaaggttga
      841 gctatatgta ccctagccat ttggaaaaga caggaacttg ggatccttgg tgggtgctag
      901 ttatttatgg tagtatttaa gctaatagat gttacgtatt cgtgatctga atgccagcca
      961 tcttcacatt gcacacttgt gttcaatatt ctttataatg aagtaacttg tgcaatacgg
     1021 aagtgagtca cgaagtttgc gctctggatg gtgttgcgta acagcggggc cctcggtctt
     1081 aagtagtgta tgtttagcag ctcctaaaat gatcttctct tggtgcttgc ggtggtgtta
     1141 cccctcatcc ctgcatttgg gaagtagaac gcctttcgtg gctagatagc gagtttgtgg
     1201 ccgtttctga actacattag accgtgtctc aaaatatgtt tctgtctccc ctcgagtttt
     1261 agctgcatgg cagcctctta tccagcactg attctgagaa tcagcctgat tttacttaaa
     1321 agcaaaaccg attttttttt ttttttttta ggggtgactg ttagctttcc tgggatcagg
     1381 tttcttcttt tccgtaactg ttgagttggg tgatggcgcc tcaaggaagg aaagggtcgt
     1441 gtgagttaac gtaacgcgga gagccaaacc ccagggccct ggaaatgcga ttcttgcctt
     1501 ggtcattccg tttcctgctc actcagtaac catcattctg ttagcaggag ccacaaaaca
     1561 tcccatgcta cggaggtttc actctgggtt cttcccctcc acccccgggg gggagtcaga
     1621 gttcaagtct tcctcttcat ttgcagtatt tcccctcgaa atttatttca ttcccagtat
     1681 tggtatgacg tctacaccac gtgctagtaa ctgagggtac agctgtgaat gaggccagct
     1741 aggtctcact gtcccgaaca cgtggtcccc cccccatggt ttctgaagac agcaaaaagg
     1801 acaaataaag aatatattac aaatctg
//
