LOCUS       NM_178187                558 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus H2A clustered histone 8 (H2ac8), mRNA.
ACCESSION   NM_178187
VERSION     NM_178187.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 558)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 558)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   3  (bases 1 to 558)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592149.8.
            
            On Feb 26, 2014 this sequence version replaced NM_178187.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK028026.1, BC058544.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               AL592149.8         51269-51826         c
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.8 cM"
     gene            1..558
                     /gene="H2ac8"
                     /gene_synonym="1190022L06; Hist1h2ae"
                     /note="H2A clustered histone 8"
                     /db_xref="GeneID:319166"
                     /db_xref="MGI:MGI:2448290"
     exon            1..558
                     /gene="H2ac8"
                     /gene_synonym="1190022L06; Hist1h2ae"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..505
                     /gene="H2ac8"
                     /gene_synonym="1190022L06; Hist1h2ae"
                     /note="histone H2A type 1; histone 1, H2ae; histone
                     cluster 1, H2ae"
                     /codon_start=1
                     /product="histone H2A type 1-E"
                     /protein_id="NP_835494.1"
                     /db_xref="CCDS:CCDS26348.1"
                     /db_xref="GeneID:319166"
                     /db_xref="MGI:MGI:2448290"
                     /translation="MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
     regulatory      532..537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2ac8"
                     /gene_synonym="1190022L06; Hist1h2ae"
                     /note="hexamer: AACAAA"
     polyA_site      558
                     /gene="H2ac8"
                     /gene_synonym="1190022L06; Hist1h2ae"
                     /note="major polyA site"
ORIGIN      
        1 acacatcagc ttttccactt ccatgtacga gtataagtag cttctcgtct ggccttttag
       61 taccgcttcg ttgtaattct ttgcaattat aatttcctac cttcttgcgt caatgtctgg
      121 acgtggcaaa cagggtggca aggctcgcgc caaggccaag acccgctcct cccgggccgg
      181 cctgcagttt cccgtgggcc gcgtgcaccg gctgctccgc aaaggcaact actcggagcg
      241 cgtgggcgcc ggcgccccgg tgtacctggc ggccgtgctg gagtacctga cggccgagat
      301 cctggagctg gcgggcaacg cggcccgcga caacaagaag acgcgcatca tcccgcgcca
      361 cctgcagctg gccatccgca acgacgagga gctcaacaag ctgctgggcc gcgtgaccat
      421 cgcgcagggc ggcgtcctgc ccaacatcca ggccgtgctg ctgcccaaga agaccgagag
      481 ccaccacaag gccaagggga aataagatct ttcttctaat ctcgtaaaaa aaacaaaggc
      541 tcttttcaga gccattca
//
