LOCUS       NM_178188                535 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H2A clustered histone 7 (H2ac7), mRNA.
ACCESSION   NM_178188
VERSION     NM_178188.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 535)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   2  (bases 1 to 535)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   3  (bases 1 to 535)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592149.8.
            
            On Feb 25, 2014 this sequence version replaced NM_178188.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC119295.1, BU505985.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-535               AL592149.8         54987-55521
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.8 cM"
     gene            1..535
                     /gene="H2ac7"
                     /gene_synonym="Hist1h2ad"
                     /note="H2A clustered histone 7"
                     /db_xref="GeneID:319165"
                     /db_xref="MGI:MGI:2448289"
     exon            1..535
                     /gene="H2ac7"
                     /gene_synonym="Hist1h2ad"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..483
                     /gene="H2ac7"
                     /gene_synonym="Hist1h2ad"
                     /note="histone H2A type 1; histone 1, H2ad; histone
                     cluster 1, H2ad"
                     /codon_start=1
                     /product="histone H2A type 1-D"
                     /protein_id="NP_835495.1"
                     /db_xref="CCDS:CCDS26351.1"
                     /db_xref="GeneID:319165"
                     /db_xref="MGI:MGI:2448289"
                     /translation="MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
     regulatory      509..514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2ac7"
                     /gene_synonym="Hist1h2ad"
                     /note="hexamer: AACAAA"
     polyA_site      535
                     /gene="H2ac7"
                     /gene_synonym="Hist1h2ad"
                     /note="major polyA site"
ORIGIN      
        1 cataggtcct ttttcgcgcc cagcgaataa tataaaggct acgttcttgt ttcaaaacca
       61 ttagttctta gtaactgctt aatctgtaca atgtctggac gcggcaaaca gggtggcaag
      121 gctcgcgcca aggccaagac ccgctcctcc cgggccggcc tgcagttccc cgtgggccgc
      181 gtgcaccggc tgctccgcaa gggcaactac tcggagcgcg tgggcgccgg cgccccggtg
      241 tacctggcgg ccgtgctgga gtacctgacg gccgagatcc tggagctggc gggcaacgcg
      301 gcccgcgaca acaagaagac gcgcatcatc ccgcgccacc tgcagctggc catccgcaac
      361 gacgaggagc tcaacaagct gctgggccgc gtgaccatcg cgcagggcgg cgtcctgccc
      421 aacatccagg ccgtgctgct gcccaagaag accgagagcc accacaaggc caaggggaaa
      481 taagattggt cttctgaact tgtataaaaa caaaggctct tttcagagcc atcca
//
