LOCUS       NM_175660                517 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus H2A clustered histone 4 (H2ac4), mRNA.
ACCESSION   NM_175660
VERSION     NM_175660.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Chai,X., Wang,G., Hong,X., Feng,M., Wang,H., Liu,F., Yao,W., Zhu,D.
            and Li,Q.
  TITLE     Inhibition of HIST1H2AB suppresses the proliferation of lung
            adenocarcinoma
  JOURNAL   J Gene Med 25 (5), e3469 (2023)
   PUBMED   36511295
  REMARK    GeneRIF: Inhibition of HIST1H2AB suppresses the proliferation of
            lung adenocarcinoma.
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Kujirai,T. and Kurumizaka,H.
  TITLE     Transcription through the nucleosome
  JOURNAL   Curr Opin Struct Biol 61, 42-49 (2020)
   PUBMED   31790919
  REMARK    Review article
REFERENCE   3  (bases 1 to 517)
  AUTHORS   Goffena,J., Lefcort,F., Zhang,Y., Lehrmann,E., Chaverra,M.,
            Felig,J., Walters,J., Buksch,R., Becker,K.G. and George,L.
  TITLE     Elongator and codon bias regulate protein levels in mammalian
            peripheral neurons
  JOURNAL   Nat Commun 9 (1), 889 (2018)
   PUBMED   29497044
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 517)
  AUTHORS   Jung,E.M., Moffat,J.J., Liu,J., Dravid,S.M., Gurumurthy,C.B. and
            Kim,W.Y.
  TITLE     Arid1b haploinsufficiency disrupts cortical interneuron development
            and mouse behavior
  JOURNAL   Nat Neurosci 20 (12), 1694-1707 (2017)
   PUBMED   29184203
REFERENCE   5  (bases 1 to 517)
  AUTHORS   Tachiwana,H., Kagawa,W., Shiga,T., Osakabe,A., Miya,Y., Saito,K.,
            Hayashi-Takanaka,Y., Oda,T., Sato,M., Park,S.Y., Kimura,H. and
            Kurumizaka,H.
  TITLE     Crystal structure of the human centromeric nucleosome containing
            CENP-A
  JOURNAL   Nature 476 (7359), 232-235 (2011)
   PUBMED   21743476
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 517)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 517)
  AUTHORS   Gruber,A., Streit,A., Reist,M., Benninger,P., Bohni,R. and
            Schumperli,D.
  TITLE     Structure of a mouse histone-encoding gene cluster
  JOURNAL   Gene 95 (2), 303-304 (1990)
   PUBMED   2249786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590388.4.
            
            On Oct 25, 2022 this sequence version replaced NM_175660.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails; instead, they
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AI787920.1, AV467081.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               AL590388.4         136784-137300       c
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.91 cM"
     gene            1..517
                     /gene="H2ac4"
                     /gene_synonym="H2a-53; H2A.1; Hist1h2ab"
                     /note="H2A clustered histone 4"
                     /db_xref="GeneID:319172"
                     /db_xref="MGI:MGI:2448306"
     exon            1..517
                     /gene="H2ac4"
                     /gene_synonym="H2a-53; H2A.1; Hist1h2ab"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..448
                     /gene="H2ac4"
                     /gene_synonym="H2a-53; H2A.1; Hist1h2ab"
                     /note="histone H2A type 1; histone 1, H2ab; histone
                     cluster 1, H2ab"
                     /codon_start=1
                     /product="histone H2A type 1-B"
                     /protein_id="NP_783591.2"
                     /db_xref="CCDS:CCDS26364.1"
                     /db_xref="GeneID:319172"
                     /db_xref="MGI:MGI:2448306"
                     /translation="MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
     regulatory      489..494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2ac4"
                     /gene_synonym="H2a-53; H2A.1; Hist1h2ab"
                     /note="hexamer: AACAAA"
     polyA_site      490
                     /gene="H2ac4"
                     /gene_synonym="H2a-53; H2A.1; Hist1h2ab"
     polyA_site      517
                     /gene="H2ac4"
                     /gene_synonym="H2a-53; H2A.1; Hist1h2ab"
                     /note="major polyA site"
ORIGIN      
        1 actatatatt cttttccttt ctctgctttg cctttactga tacttaaacg catacatgtc
       61 tggacgcgga aagcagggtg gcaaggcccg cgctaaggcc aagacccgct cctcccgggc
      121 cggcctgcag ttccccgtag gccgcgtgca tcggctgctc cgcaagggca actactcgga
      181 gcgcgtgggc gccggcgccc cggtgtacct ggcggccgtg ctggagtacc tgacggccga
      241 gatcctggag ctggcgggca acgcggcccg cgacaacaag aagacgcgca tcatcccgcg
      301 ccacctgcag ctggccatcc gcaacgacga ggagctcaac aagctgctgg gccgcgtgac
      361 catcgcgcag ggcggcgtcc tgcccaacat ccaggccgtg ctgctgccca agaagaccga
      421 gagccaccac aaggccaagg ggaagtaatc tggcgattgt ctgtactgcc cagttgaaag
      481 ttaaccaaaa caaaggctct tttcagagcc acccaca
//
