LOCUS       NM_178184                475 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H2A clustered histone 22 (H2ac22), mRNA.
ACCESSION   NM_178184
VERSION     NM_178184.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL589651.8.
            
            On Jun 19, 2019 this sequence version replaced NM_178184.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. This structure consists of approximately 146 bp of DNA
            wrapped around a nucleosome, an octamer composed of pairs of each
            of the four core histones (H2A, H2B, H3, and H4). The chromatin
            fiber is further compacted through the interaction of a linker
            histone, H1, with the DNA between the nucleosomes to form higher
            order chromatin structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. [provided by RefSeq, Aug 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-475               AL589651.8         207764-208238       c
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.97 cM"
     gene            1..475
                     /gene="H2ac22"
                     /gene_synonym="Hist1h2an"
                     /note="H2A clustered histone 22"
                     /db_xref="GeneID:319170"
                     /db_xref="MGI:MGI:2448300"
     exon            1..475
                     /gene="H2ac22"
                     /gene_synonym="Hist1h2an"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..423
                     /gene="H2ac22"
                     /gene_synonym="Hist1h2an"
                     /note="histone H2A type 1; histone 1, H2an; histone
                     cluster 1, H2an"
                     /codon_start=1
                     /product="histone H2A type 1-N"
                     /protein_id="NP_835491.1"
                     /db_xref="CCDS:CCDS26297.1"
                     /db_xref="GeneID:319170"
                     /db_xref="MGI:MGI:2448300"
                     /translation="MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
     regulatory      450..455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2ac22"
                     /gene_synonym="Hist1h2an"
                     /note="hexamer: AACAAA"
     polyA_site      475
                     /gene="H2ac22"
                     /gene_synonym="Hist1h2an"
                     /note="major polyA site"
ORIGIN      
        1 gcagttgtca gttctttctt tttgtttaga atgtctggac gcggcaaaca gggcggcaag
       61 gctcgcgcca aggccaagac ccgctcctcc cgggccggcc tgcagttccc cgtgggccgc
      121 gtgcaccggc tgctccgcaa gggcaactac tcggagcgcg tgggcgccgg cgccccggtg
      181 tacctggcgg ccgtgctgga gtacctgacg gccgagatcc tggagctggc gggcaacgcg
      241 gcccgcgaca acaagaagac gcgcatcatc ccgcgccacc tgcagctggc catccgcaac
      301 gacgaggagc tcaacaagct gctgggccgc gtgaccatcg cgcagggcgg cgtcctgccc
      361 aacatccagg ccgtactgct gccgaagaag accgagagcc accacaaggc caagggaaaa
      421 taagacaatt gtttcctgat catttaaaaa acaaaggctc ttttcagagc taaca
//
