LOCUS       NM_178213                434 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Mus musculus H2A clustered histone 21 (H2ac21), mRNA.
ACCESSION   NM_178213 XM_977100
VERSION     NM_178213.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 434)
  AUTHORS   Ancelin,K., Lange,U.C., Hajkova,P., Schneider,R., Bannister,A.J.,
            Kouzarides,T. and Surani,M.A.
  TITLE     Blimp1 associates with Prmt5 and directs histone arginine
            methylation in mouse germ cells
  JOURNAL   Nat Cell Biol 8 (6), 623-630 (2006)
   PUBMED   16699504
REFERENCE   2  (bases 1 to 434)
  AUTHORS   Fang,J., Chen,T., Chadwick,B., Li,E. and Zhang,Y.
  TITLE     Ring1b-mediated H2A ubiquitination associates with inactive X
            chromosomes and is involved in initiation of X inactivation
  JOURNAL   J Biol Chem 279 (51), 52812-52815 (2004)
   PUBMED   15509584
REFERENCE   3  (bases 1 to 434)
  AUTHORS   de Napoles,M., Mermoud,J.E., Wakao,R., Tang,Y.A., Endoh,M.,
            Appanah,R., Nesterova,T.B., Silva,J., Otte,A.P., Vidal,M.,
            Koseki,H. and Brockdorff,N.
  TITLE     Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A
            to heritable gene silencing and X inactivation
  JOURNAL   Dev Cell 7 (5), 663-676 (2004)
   PUBMED   15525528
REFERENCE   4  (bases 1 to 434)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   5  (bases 1 to 434)
  AUTHORS   Wang,Z.F., Tisovec,R., Debry,R.W., Frey,M.R., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the 55-kb mouse histone gene cluster on
            chromosome 3
  JOURNAL   Genome Res 6 (8), 702-714 (1996)
   PUBMED   8858345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125099.3.
            
            On Jun 28, 2022 this sequence version replaced NM_178213.5.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. [provided by RefSeq, Aug 2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR13862062.181242.1,
                                        SRR13422591.155298.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-434               AC125099.3         55736-56169         c
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.67 cM"
     gene            1..434
                     /gene="H2ac21"
                     /gene_synonym="EG621893; H2a-613a; Hist2h2ab"
                     /note="H2A clustered histone 21"
                     /db_xref="GeneID:621893"
                     /db_xref="MGI:MGI:2448314"
     exon            1..434
                     /gene="H2ac21"
                     /gene_synonym="EG621893; H2a-613a; Hist2h2ab"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..424
                     /gene="H2ac21"
                     /gene_synonym="EG621893; H2a-613a; Hist2h2ab"
                     /note="histone 2, H2ab; histone cluster 2, H2ab"
                     /codon_start=1
                     /product="histone H2A type 2-B"
                     /protein_id="NP_835585.3"
                     /db_xref="CCDS:CCDS38553.1"
                     /db_xref="GeneID:621893"
                     /db_xref="MGI:MGI:2448314"
                     /translation="MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGGVT
                     IAQGGVLPNIQAVLLPKKTESHKPGKNK"
ORIGIN      
        1 ggaaaaagca gcagaaattg cttattccgc catgtctggc cgtggcaaac aaggaggcaa
       61 ggcccgcgcc aaggcgaagt cgcggtcgtc ccgcgccggg ctgcagttcc cggtggggcg
      121 tgtgcaccgg ctgctgcgca agggcaacta cgcggagcgc gtgggcgccg gcgcgccggt
      181 gtacatggcg gcggtgctgg agtacctaac ggccgagatc ctggagctgg cgggcaacgc
      241 ggcccgcgac aacaagaaga cgcgcatcat cccgcgccat ctgcaactag ctgtgaggaa
      301 cgatgaggag ctcaacaagt tactaggggg agtcaccatc gcccagggcg gggtcctccc
      361 caatattcag gctgtcttac ttccgaagaa aacggaaagt cataagcctg gaaagaacaa
      421 ataactatta tccc
//
