LOCUS       NM_175662                482 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus H2A clustered histone 20 (H2ac20), mRNA.
ACCESSION   NM_175662
VERSION     NM_175662.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Monteiro,F.L., Vitorino,R., Wang,J., Cardoso,H., Laranjeira,H.,
            Simoes,J., Caldas,M., Henrique,R., Amado,F., Williams,C.,
            Jeronimo,C. and Helguero,L.A.
  TITLE     The histone H2A isoform Hist2h2ac is a novel regulator of
            proliferation and epithelial-mesenchymal transition in mammary
            epithelial and in breast cancer cells
  JOURNAL   Cancer Lett 396, 42-52 (2017)
   PUBMED   28288875
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Yasunaga,S., Ohtsubo,M., Ohno,Y., Saeki,K., Kurogi,T.,
            Tanaka-Okamoto,M., Ishizaki,H., Shirai,M., Mihara,K., Brock,H.W.,
            Miyoshi,J. and Takihara,Y.
  TITLE     Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A
            and regulates geminin stability directly or indirectly via
            transcriptional repression of Hoxa9 and Hoxb4
  JOURNAL   Mol Cell Biol 33 (4), 644-660 (2013)
   PUBMED   23207902
REFERENCE   3  (bases 1 to 482)
  AUTHORS   Wu,J., Chen,Y., Lu,L.Y., Wu,Y., Paulsen,M.T., Ljungman,M.,
            Ferguson,D.O. and Yu,X.
  TITLE     Chfr and RNF8 synergistically regulate ATM activation
  JOURNAL   Nat Struct Mol Biol 18 (7), 761-768 (2011)
   PUBMED   21706008
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 482)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   5  (bases 1 to 482)
  AUTHORS   Wang,Z.F., Tisovec,R., Debry,R.W., Frey,M.R., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the 55-kb mouse histone gene cluster on
            chromosome 3
  JOURNAL   Genome Res 6 (8), 702-714 (1996)
   PUBMED   8858345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125099.3.
            
            On Jun 28, 2022 this sequence version replaced NM_175662.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. [provided by RefSeq, Aug 2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC117096.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               AC125099.3         55161-55642
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.67 cM"
     gene            1..482
                     /gene="H2ac20"
                     /gene_synonym="H2a-613b; Hist2h2ac"
                     /note="H2A clustered histone 20"
                     /db_xref="GeneID:319176"
                     /db_xref="MGI:MGI:2448316"
     exon            1..482
                     /gene="H2ac20"
                     /gene_synonym="H2a-613b; Hist2h2ac"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..439
                     /gene="H2ac20"
                     /gene_synonym="H2a-613b; Hist2h2ac"
                     /note="histone 2, H2ac; histone cluster 2, H2ac"
                     /codon_start=1
                     /product="histone H2A type 2-C"
                     /protein_id="NP_783593.1"
                     /db_xref="CCDS:CCDS17634.1"
                     /db_xref="GeneID:319176"
                     /db_xref="MGI:MGI:2448316"
                     /translation="MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVT
                     IAQGGVLPNIQAVLLPKKTESHKAKSK"
     polyA_site      482
                     /gene="H2ac20"
                     /gene_synonym="H2a-613b; Hist2h2ac"
                     /note="major polyA site"
ORIGIN      
        1 gctttacaga agttgtcacc tcggtgtgtc ctacattata ctctaagtta tgtctggccg
       61 tggcaaacag ggaggcaagg cccgcgccaa ggccaagtcg cggtcttccc gggccgggct
      121 acagttcccg gtggggcgtg tgcaccggct gctgcgcaag ggcaactacg cggagcgcgt
      181 gggcgccggc gcgccggtat acatggcggc ggtgctggag tacctaacgg ccgagatcct
      241 ggagctggcg ggcaacgcgg cccgcgacaa caagaagacg cgcatcatcc cgcgccatct
      301 gcagctggcc atccgcaacg acgaggagct caacaagctg ctgggcaaag tgacgatcgc
      361 acagggcggc gtcctgccca acatccaggc cgtgctgctg cccaagaaga ccgagagcca
      421 caaggctaag agcaagtgaa actcaacacg aatccaaaaa ggctcttttt agagccacca
      481 aa
//
